6CG2
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CRYSTAL STRUCTURE OF KDM4A WITH COMPOUND 8
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J., Nie, Z.
Deposit date:2018-02-19
Release date:2018-04-18
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structure-based design and discovery of potent and selective KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
6CG1
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CRYSTAL STRUCTURE OF KDM4A WITH COMPOUND 14
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J., Nie, Z.
Deposit date:2018-02-19
Release date:2018-04-18
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structure-based design and discovery of potent and selective KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
5ZNR
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CRYSTAL STRUCTURE OF PTSHL IN COMPLEX WITH AN H3K27ME3 PEPTIDE
Descriptor:SHORT LIFE family protein, 17-mer peptide from Histone H3.2, ZINC ION, ...
Authors:Lv, X., Du, J.
Deposit date:2018-04-10
Release date:2018-07-18
Method:X-RAY DIFFRACTION (3.202 Å)
Cite:Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.
Nat Commun, 9, 2018
5ZNP
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CRYSTAL STRUCTURE OF PTSHL IN COMPLEX WITH AN H3K4ME3 PEPTIDE
Descriptor:SHORT LIFE family protein, 15-mer peptide from Histone H3.2, ZINC ION
Authors:Lv, X., Du, J.
Deposit date:2018-04-10
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.
Nat Commun, 9, 2018
5YKO
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA JMJ14 CATALYTIC DOMAIN IN COMPLEX WITH NOG AND H3K4ME3 PEPTIDE
Descriptor:Probable lysine-specific demethylase JMJ14, H3(1-10)K4me3 peptide, NICKEL (II) ION, ...
Authors:Yang, Z., Du, J.
Deposit date:2017-10-15
Release date:2017-12-27
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases.
Plant Cell, 30, 2018
5YKN
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA JMJ14 CATALYTIC DOMAIN
Descriptor:Probable lysine-specific demethylase JMJ14, NICKEL (II) ION, ZINC ION
Authors:Yang, Z., Du, J.
Deposit date:2017-10-15
Release date:2017-12-27
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases.
Plant Cell, 30, 2018
5YC4
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CRYSTAL STRUCTURE OF AL3 PHD FINGER BOUND TO H3K4ME3
Descriptor:PHD finger protein ALFIN-LIKE 3, Histone H3K4me3, ZINC ION
Authors:Zhao, S., Zhang, B., Li, H.
Deposit date:2017-09-06
Release date:2018-01-24
Method:X-RAY DIFFRACTION (2.697 Å)
Cite:Crystal structure of AL1 PHD finger bound to H3K4me3
Cell Rep, 2018
5YC3
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CRYSTAL STRUCTURE OF AL3 PHD FINGER BOUND TO H3K4ME2
Descriptor:PHD finger protein ALFIN-LIKE 3, H3K4me2, ZINC ION
Authors:Zhao, S., Zhang, B., Li, H.
Deposit date:2017-09-06
Release date:2018-01-24
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Crystal structure of AL1 PHD finger bound to H3K4me3
Cell Rep, 2018
5Y5W
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CRYSTAL STRUCTURE OF HUMAN SPINDLIN1 IN COMPLEX WITH A HISTONE H4K20(ME3) PEPTIDE
Descriptor:Spindlin-1, Histone peptide H4K20(me3)
Authors:Wang, C.L., Zang, J.Y.
Deposit date:2017-08-10
Release date:2017-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of human Spindlin1 in complex with a histone H4K20(me3) peptide
To Be Published
5Y20
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CRYSTAL STRUCTURE OF AL1 PHD FINGER BOUND TO H3K4ME3
Descriptor:PHD finger protein ALFIN-LIKE 1, PEPTIDE FROM HISTONE H3, ZINC ION
Authors:Zhao, S., Zhang, B., Li, H.
Deposit date:2017-07-22
Release date:2018-01-24
Method:X-RAY DIFFRACTION (2.409 Å)
Cite:Crystal structure of AL1 PHD finger bound to H3K4me3
Cell Rep, 2018
5XMY
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CRYSTAL STRUCTURE OF TAF3 PHD FINGER BOUND TO H3K4ME3Q5SER
Descriptor:Transcription initiation factor TFIID subunit 3, Histone peptide H3(1-15)K4me3Q5ser, ZINC ION
Authors:Zhao, S., Zhang, B., Li, H.
Deposit date:2017-05-16
Release date:2018-11-28
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Crystal structure of TAF3 PHD finger bound to H3K4me3Q5ser
to be published
5WXH
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CRYSTAL STRUCTURE OF TAF3 PHD FINGER BOUND TO H3K4ME3
Descriptor:Transcription initiation factor TFIID subunit 3, Histone H3K4me3, ZINC ION
Authors:Zhao, S., Huang, J., Li, H.
Deposit date:2017-01-07
Release date:2017-08-16
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.297 Å)
Cite:Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WLF
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CRYSTAL STRUCTURE OF THE APO PPS PHD FINGER
Descriptor:Protein partner of snf, isoform A, GLYCEROL, ...
Authors:Klein, B.J., Kutateladze, T.G.
Deposit date:2017-07-26
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.
Structure, 25, 2017
5WLE
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CRYSTAL STRUCTURE OF THE PPS PHD FINGER IN COMPLEX WITH H3K4ME3
Descriptor:Protein partner of snf, isoform A, H3K4me3 Peptide, ...
Authors:Klein, B.J., Kutateladze, T.G.
Deposit date:2017-07-26
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.
Structure, 25, 2017
5VMP
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CRYSTAL STRUCTURE OF HUMAN KDM4 WITH SMALL MOLECULE INHIBITOR QC5714
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J.
Deposit date:2017-04-28
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
ACS Med Chem Lett, 8, 2017
5VGI
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CRYSTAL STRUCTURE OF KDM4 WITH THE SMALL MOLECULE INHIBITOR QC6352
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J.
Deposit date:2017-04-11
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
ACS Med Chem Lett, 8, 2017
5TVS
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JMJD2A IN COMPLEX WITH NI(II)
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION
Authors:Cascella, B., Lee, S.G., Jez, J.M.
Deposit date:2016-11-09
Release date:2017-02-01
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.745 Å)
Cite:The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53, 2017
5TVR
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JMJD2A IN COMPLEX WITH NI(II) AND ALPHA-KETOGLUTARATE
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:Cascella, B., Lee, S.G., Jez, J.M.
Deposit date:2016-11-09
Release date:2017-02-01
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53, 2017
5TDW
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SET3 PHD FINGER IN COMPLEX WITH HISTONE H3K4ME3
Descriptor:SET domain-containing protein 3, histone H3K4me3, ZINC ION, ...
Authors:Andrews, F.H., Ali, M., Kutateladze, T.G.
Deposit date:2016-09-19
Release date:2016-10-19
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insight into Recognition of Methylated Histone H3K4 by Set3.
J. Mol. Biol., 429, 2017
5SVX
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MORC3 CW IN COMPLEX WITH HISTONE H3K4ME3
Descriptor:MORC family CW-type zinc finger protein 3, H3K4me3, ZINC ION
Authors:Tong, Q., Andrews, F.H., Kutateladze, T.G.
Deposit date:2016-08-08
Release date:2016-10-05
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Cell Rep, 16, 2016
5MTO
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N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5 C19S MUTANT
Descriptor:Inhibitor of growth protein 5, SODIUM ION, SULFATE ION
Authors:Ormaza, G., Buitrago, J.A.R., Roversi, P., Rojas, A.L., Blanco, F.J.
Deposit date:2017-01-10
Release date:2018-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:N-terminal domain of the human tumor suppressor ING5 C19S mutant
To Be Published
5ME8
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N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5
Descriptor:Inhibitor of growth protein 5, (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL
Authors:Roversi, P., Blanco, F.J., Rojas, A.L., Buitrago, J.A.R.
Deposit date:2016-11-14
Release date:2018-03-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The tumor suppressor ING5 is a dimeric molecule with Bivalent Recognition of the H3K4me3 mark
To Be Published
5LY2
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JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND MACROCYCLIC PEPTIDE INHIBITOR CP2_R6KME3 (13-MER)
Descriptor:Lysine-specific demethylase 4A, CP2_R6Kme3, NICKEL (II) ION, ...
Authors:CHOWDHURY, R., Madden, S.K., Hopkinson, R., SCHOFIELD, C.J.
Deposit date:2016-09-23
Release date:2017-04-12
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
5LY1
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JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND MACROCYCLIC PEPTIDE INHIBITOR CP2 (13-MER)
Descriptor:Lysine-specific demethylase 4A, CP2, NICKEL (II) ION, ...
Authors:King, O.N.F., Chowdhury, R., Kawamura, A., Schofield, C.J.
Deposit date:2016-09-23
Release date:2017-04-12
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
5JSJ
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CRYSTAL STRUCTURE OF SPINDLIN1 BOUND TO COMPOUND EML631
Descriptor:Spindlin-1, [4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]-[4-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl-3-[[4-(pyrrolidin-1-ylmethoxy)phenyl]amino]phenyl]methanone, MAGNESIUM ION, ...
Authors:Su, X., Li, H.
Deposit date:2016-05-08
Release date:2017-05-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.348 Å)
Cite:Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Nat. Chem. Biol., 13, 2017
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