6CG2 | | CRYSTAL STRUCTURE OF KDM4A WITH COMPOUND 8 | | Descriptor: | Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... | | Authors: | Hosfield, D.J., Nie, Z. | | Deposit date: | 2018-02-19 | | Release date: | 2018-04-18 | | Last modified: | 2018-05-02 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Structure-based design and discovery of potent and selective KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
|
|
6CG1 | | CRYSTAL STRUCTURE OF KDM4A WITH COMPOUND 14 | | Descriptor: | Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... | | Authors: | Hosfield, D.J., Nie, Z. | | Deposit date: | 2018-02-19 | | Release date: | 2018-04-18 | | Last modified: | 2018-05-02 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Structure-based design and discovery of potent and selective KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
|
|
5ZNR | |
5ZNP | |
5YKO | |
5YKN | | CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA JMJ14 CATALYTIC DOMAIN | | Descriptor: | Probable lysine-specific demethylase JMJ14, NICKEL (II) ION, ZINC ION | | Authors: | Yang, Z., Du, J. | | Deposit date: | 2017-10-15 | | Release date: | 2017-12-27 | | Last modified: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases.
Plant Cell, 30, 2018
|
|
5YC4 | |
5YC3 | |
5Y5W | |
5Y20 | |
5XMY | |
5WXH | | CRYSTAL STRUCTURE OF TAF3 PHD FINGER BOUND TO H3K4ME3 | | Descriptor: | Transcription initiation factor TFIID subunit 3, Histone H3K4me3, ZINC ION | | Authors: | Zhao, S., Huang, J., Li, H. | | Deposit date: | 2017-01-07 | | Release date: | 2017-08-16 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (1.297 Å) | | Cite: | Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
5WLF | |
5WLE | |
5VMP | |
5VGI | |
5TVS | | JMJD2A IN COMPLEX WITH NI(II) | | Descriptor: | Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION | | Authors: | Cascella, B., Lee, S.G., Jez, J.M. | | Deposit date: | 2016-11-09 | | Release date: | 2017-02-01 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (2.745 Å) | | Cite: | The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53, 2017
|
|
5TVR | | JMJD2A IN COMPLEX WITH NI(II) AND ALPHA-KETOGLUTARATE | | Descriptor: | Lysine-specific demethylase 4A, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ... | | Authors: | Cascella, B., Lee, S.G., Jez, J.M. | | Deposit date: | 2016-11-09 | | Release date: | 2017-02-01 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (2.093 Å) | | Cite: | The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53, 2017
|
|
5TDW | | SET3 PHD FINGER IN COMPLEX WITH HISTONE H3K4ME3 | | Descriptor: | SET domain-containing protein 3, histone H3K4me3, ZINC ION, ... | | Authors: | Andrews, F.H., Ali, M., Kutateladze, T.G. | | Deposit date: | 2016-09-19 | | Release date: | 2016-10-19 | | Last modified: | 2017-06-28 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Insight into Recognition of Methylated Histone H3K4 by Set3.
J. Mol. Biol., 429, 2017
|
|
5SVX | |
5MTO | | N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5 C19S MUTANT | | Descriptor: | Inhibitor of growth protein 5, SODIUM ION, SULFATE ION | | Authors: | Ormaza, G., Buitrago, J.A.R., Roversi, P., Rojas, A.L., Blanco, F.J. | | Deposit date: | 2017-01-10 | | Release date: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | N-terminal domain of the human tumor suppressor ING5 C19S mutant
To Be Published
|
|
5ME8 | | N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5 | | Descriptor: | Inhibitor of growth protein 5, (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL | | Authors: | Roversi, P., Blanco, F.J., Rojas, A.L., Buitrago, J.A.R. | | Deposit date: | 2016-11-14 | | Release date: | 2018-03-14 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | The tumor suppressor ING5 is a dimeric molecule with Bivalent Recognition of the H3K4me3 mark
To Be Published
|
|
5LY2 | | JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND MACROCYCLIC PEPTIDE INHIBITOR CP2_R6KME3 (13-MER) | | Descriptor: | Lysine-specific demethylase 4A, CP2_R6Kme3, NICKEL (II) ION, ... | | Authors: | CHOWDHURY, R., Madden, S.K., Hopkinson, R., SCHOFIELD, C.J. | | Deposit date: | 2016-09-23 | | Release date: | 2017-04-12 | | Last modified: | 2017-04-19 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
|
|
5LY1 | | JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND MACROCYCLIC PEPTIDE INHIBITOR CP2 (13-MER) | | Descriptor: | Lysine-specific demethylase 4A, CP2, NICKEL (II) ION, ... | | Authors: | King, O.N.F., Chowdhury, R., Kawamura, A., Schofield, C.J. | | Deposit date: | 2016-09-23 | | Release date: | 2017-04-12 | | Last modified: | 2017-04-19 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
|
|
5JSJ | | CRYSTAL STRUCTURE OF SPINDLIN1 BOUND TO COMPOUND EML631 | | Descriptor: | Spindlin-1, [4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]-[4-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl-3-[[4-(pyrrolidin-1-ylmethoxy)phenyl]amino]phenyl]methanone, MAGNESIUM ION, ... | | Authors: | Su, X., Li, H. | | Deposit date: | 2016-05-08 | | Release date: | 2017-05-24 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (2.348 Å) | | Cite: | Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Nat. Chem. Biol., 13, 2017
|
|
