Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

9QLM
DownloadVisualize
BU of 9qlm by Molmil
Solution structure of the TAF3-PHD bound to a H3K4me3Q5ser histone tail peptide with a serotonylated glutamine
Descriptor: Histone H3.1, SEROTONIN, Transcription initiation factor TFIID subunit 3, ...
Authors:van Ingen, H, Gielingh, H, Pulido-Cortes, L, Thijssen, V, Timmers, H.Th.M, Jongkees, S, Honorato, R.V, Bonvin, A.M.J.J, Liu, M, Yoshisada, R, Soares, L.R.
Deposit date:2025-03-21
Release date:2025-05-14
Method:SOLUTION NMR
Cite:Molecular determinants for recognition of serotonylated chromatin
To Be Published
9GP4
DownloadVisualize
BU of 9gp4 by Molmil
Jumonji domain-containing protein 2A with crystallization epitope mutations Q953E:A958D
Descriptor: 1,2-ETHANEDIOL, Lysine-specific demethylase 4A, SULFATE ION
Authors:Fairhead, M, Strain-Damerell, C, Ye, M, Mackinnon, S.R, Pinkas, D, MacLean, E.M, Koekemoer, L, Damerell, D, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, Yue, W, Burgess-Brown, N, Marsden, B, von Delft, F, Structural Genomics Consortium (SGC)
Deposit date:2024-09-06
Release date:2024-10-16
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:A fast, parallel method for efficiently exploring crystallization behaviour of large numbers of protein variants
To be published
9GII
DownloadVisualize
BU of 9gii by Molmil
Jumonji domain-containing protein 2A with crystallization epitope mutation R913A
Descriptor: GLYCEROL, Lysine-specific demethylase 4A, SULFATE ION
Authors:Fairhead, M, Strain-Damerell, C, Ye, M, Mackinnon, S.R, Pinkas, D, MacLean, E.M, Koekemoer, L, Damerell, D, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, Yue, W, Burgess-Brown, N, Marsden, B, von Delft, F, Structural Genomics Consortium (SGC)
Deposit date:2024-08-19
Release date:2024-09-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A fast, parallel method for efficiently exploring crystallization behaviour of large numbers of protein variants
To be published
9GD3
DownloadVisualize
BU of 9gd3 by Molmil
Structure of a mononucleosome bound by one copy of Chd1 with the DBD on the exit-side DNA.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ...
Authors:Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L.
Deposit date:2024-08-04
Release date:2024-09-18
Last modified:2024-10-02
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT.
Mol.Cell, 84, 2024
9GD2
DownloadVisualize
BU of 9gd2 by Molmil
Structure of Chd1 bound to a dinucleosome with a dyad-to-dyad distance of 103 bp.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ...
Authors:Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L.
Deposit date:2024-08-04
Release date:2024-09-18
Last modified:2024-10-02
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT.
Mol.Cell, 84, 2024
9GD1
DownloadVisualize
BU of 9gd1 by Molmil
Structure of Chd1 bound to a hexasome-nucleosome complex with a dyad-to-dyad distance of 103 bp.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ...
Authors:Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L.
Deposit date:2024-08-04
Release date:2024-09-18
Last modified:2024-10-02
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT.
Mol.Cell, 84, 2024
9FWG
DownloadVisualize
BU of 9fwg by Molmil
LSD1/CoREST bound to bomedemstat
Descriptor: Bomedemstat FAD adduct, Lysine-specific histone demethylase 1A, REST corepressor 1
Authors:Speranzini, V, Mattevi, A.
Deposit date:2024-06-30
Release date:2024-07-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models.
Prostate, 84, 2024
9ELA
DownloadVisualize
BU of 9ela by Molmil
LSD1-CoREST in complex with T108, long soaking
Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(1R,3R,3aS,13R)-1-hydroxy-10,11-dimethyl-4,6-dioxo-3-[3-(phenylcarbamoyl)phenyl]-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate
Authors:Caroli, J, Mattevi, A.
Deposit date:2024-12-04
Release date:2025-02-05
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1
to be published
9EL8
DownloadVisualize
BU of 9el8 by Molmil
LSD1-CoREST in complex with T105 1S2R enantiomer
Descriptor: 3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide, Lysine-specific histone demethylase 1A, REST corepressor 1, ...
Authors:Caroli, J, Mattevi, A.
Deposit date:2024-12-04
Release date:2025-02-05
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1
to be published
9EL7
DownloadVisualize
BU of 9el7 by Molmil
LSD1-CoREST in complex with T105 enantiomer (1R,2S)
Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2S,3S,4R)-5-[(4aS)-7,8-dimethyl-4a-[(1R)-1-{3-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl}-3-oxopropyl]-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name)
Authors:Caroli, J, Mattevi, A.
Deposit date:2024-12-04
Release date:2025-02-05
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1
to be published
9C0O
DownloadVisualize
BU of 9c0o by Molmil
Crystal structure of DmCfp1 PHD finger bound to H3K4me3
Descriptor: CXXC-type zinc finger protein 1, DIMETHYL SULFOXIDE, Histone H3.3C, ...
Authors:Gregoire, S, Couture, J.F.
Deposit date:2024-05-27
Release date:2024-07-03
Last modified:2024-09-25
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structural insights into an atypical histone binding mechanism by a PHD finger.
Structure, 32, 2024
8WAS
DownloadVisualize
BU of 8was by Molmil
Structure of transcribing complex 9 (TC9), the initially transcribing complex with Pol II positioned 9nt downstream of TSS.
Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ...
Authors:Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y.
Deposit date:2023-09-08
Release date:2023-12-06
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (6.13 Å)
Cite:Structural visualization of transcription initiation in action.
Science, 382, 2023
8WAR
DownloadVisualize
BU of 8war by Molmil
Structure of transcribing complex 8 (TC8), the initially transcribing complex with Pol II positioned 8nt downstream of TSS.
Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ...
Authors:Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y.
Deposit date:2023-09-08
Release date:2023-12-06
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Structural visualization of transcription initiation in action.
Science, 382, 2023
8WAQ
DownloadVisualize
BU of 8waq by Molmil
Structure of transcribing complex 7 (TC7), the initially transcribing complex with Pol II positioned 7nt downstream of TSS.
Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ...
Authors:Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y.
Deposit date:2023-09-08
Release date:2023-12-06
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (6.29 Å)
Cite:Structural visualization of transcription initiation in action.
Science, 382, 2023
8WAP
DownloadVisualize
BU of 8wap by Molmil
Structure of transcribing complex 6 (TC6), the initially transcribing complex with Pol II positioned 6nt downstream of TSS.
Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ...
Authors:Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y.
Deposit date:2023-09-08
Release date:2023-12-06
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (5.85 Å)
Cite:Structural visualization of transcription initiation in action.
Science, 382, 2023
8WAO
DownloadVisualize
BU of 8wao by Molmil
Structure of transcribing complex 5 (TC5), the initially transcribing complex with Pol II positioned 5nt downstream of TSS.
Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ...
Authors:Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y.
Deposit date:2023-09-07
Release date:2023-12-06
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Structural visualization of transcription initiation in action.
Science, 382, 2023
8WAN
DownloadVisualize
BU of 8wan by Molmil
Structure of transcribing complex 4 (TC4), the initially transcribing complex with Pol II positioned 4nt downstream of TSS.
Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ...
Authors:Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y.
Deposit date:2023-09-07
Release date:2023-12-06
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (6.07 Å)
Cite:Structural visualization of transcription initiation in action.
Science, 382, 2023
8WAL
DownloadVisualize
BU of 8wal by Molmil
Structure of transcribing complex 3 (TC3), the initially transcribing complex with Pol II positioned 3nt downstream of TSS.
Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ...
Authors:Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y.
Deposit date:2023-09-07
Release date:2023-12-06
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (8.52 Å)
Cite:Structural visualization of transcription initiation in action.
Science, 382, 2023
8WAK
DownloadVisualize
BU of 8wak by Molmil
Structure of transcribing complex 2 (TC2), the initially transcribing complex with Pol II positioned 2nt downstream of TSS.
Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ...
Authors:Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y.
Deposit date:2023-09-07
Release date:2023-12-06
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (5.47 Å)
Cite:Structural visualization of transcription initiation in action.
Science, 382, 2023
8VOB
DownloadVisualize
BU of 8vob by Molmil
H3K36me3-modified nucleosome bound to PRC2_AJ1-450
Descriptor: DNA (157-MER), Histone H2A type 1, Histone H2B 1.1, ...
Authors:Cookis, T, Nogales, E.
Deposit date:2024-01-14
Release date:2025-01-15
Last modified:2025-03-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications.
Nat.Struct.Mol.Biol., 32, 2025
8VO0
DownloadVisualize
BU of 8vo0 by Molmil
H3K36me3-modified nucleosome bound to PRC2_AJ1-450 with histone H3 tail disengaged
Descriptor: DNA (157-MER), Histone H2A, Histone H2B 1.1, ...
Authors:Cookis, T, Nogales, E.
Deposit date:2024-01-14
Release date:2025-01-22
Last modified:2025-03-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications.
Nat.Struct.Mol.Biol., 32, 2025
8VNZ
DownloadVisualize
BU of 8vnz by Molmil
PRC2_AJ1-450 bound to H3K36me3-modified nucleosome with histone H3 tail disengaged
Descriptor: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, Isoform 3 of Zinc finger protein AEBP2, ...
Authors:Cookis, T, Nogales, E.
Deposit date:2024-01-14
Release date:2025-01-15
Last modified:2025-05-14
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications.
Nat.Struct.Mol.Biol., 32, 2025
8VNV
DownloadVisualize
BU of 8vnv by Molmil
PRC2_AJ1-450 bound to H3K36me3 with histone H3 tail engaged
Descriptor: DNA (26-MER), DNA (26-mer), EED, ...
Authors:Cookis, T, Nogales, E.
Deposit date:2024-01-13
Release date:2025-01-22
Last modified:2025-03-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications.
Nat.Struct.Mol.Biol., 32, 2025
8VMN
DownloadVisualize
BU of 8vmn by Molmil
H3K4me3 nucleosome bound to PRC2_AJ1-450
Descriptor: DNA (157-MER), Histone H2A, Histone H2B, ...
Authors:Cookis, T, Nogales, E.
Deposit date:2024-01-13
Release date:2025-01-22
Last modified:2025-03-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications.
Nat.Struct.Mol.Biol., 32, 2025
8VML
DownloadVisualize
BU of 8vml by Molmil
PRC2_AJ1-450 bound to H3K4me3
Descriptor: AEPB2, EED, EZH2, ...
Authors:Cookis, T, Nogales, E.
Deposit date:2024-01-13
Release date:2025-01-15
Last modified:2025-03-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications.
Nat.Struct.Mol.Biol., 32, 2025

238582

PDB entries from 2025-07-09

PDB statisticsPDBj update infoContact PDBjnumon