PDB: 266 resultsInfo pagesStatus searchChemie searchBIRD

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1NK7	GUANINE-ADENINE MISMATCH AT THE POLYMERASE ACTIVE SITE Descriptor: DNA POLYMERASE I, DNA PRIMER STRAND, DNA TEMPLATE STRAND, ... Authors: Johnson, S.J, Beese, L.S. Deposit date: 2003-01-02 Release date: 2004-03-30 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structures of mismatch replication errors observed in a DNA polymerase. Cell(Cambridge,Mass.), 116, 2004
1QSL	KLENOW FRAGMENT COMPLEXED WITH SINGLE-STRANDED SUBSTRATE AND EUROPIUM (III) ION Descriptor: 5'-D(*GP*CP*TP*TP*AP*CP*GP*C)-3', DNA POLYMERASE I, EUROPIUM ION Authors: Brautigam, C.A, Aschheim, K, Steitz, T.A. Deposit date: 1999-06-22 Release date: 1999-06-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural elucidation of the binding and inhibitory properties of lanthanide (III) ions at the 3'-5' exonucleolytic active site of the Klenow fragment Chem.Biol., 6, 1999
1QSY	DDATP-Trapped closed ternary complex of the large fragment of DNA Polymerase I from thermus aquaticus Descriptor: 2',3'-dideoxyadenosine triphosphate, 5'-D(*AP*TP*TP*GP*CP*GP*CP*CP*TP*P*GP*GP*TP*C)-3', 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(2DA))-3', ... Authors: Li, Y, Mitaxov, V, Waksman, G. Deposit date: 1999-06-24 Release date: 1999-08-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation. Proc.Natl.Acad.Sci.USA, 96, 1999
1QSS	DDGTP-TRAPPED CLOSED TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*AP*CP*CP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3', 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DDG))-3', ... Authors: Li, Y, Mitaxov, V, Waksman, G. Deposit date: 1999-06-23 Release date: 1999-08-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation. Proc.Natl.Acad.Sci.USA, 96, 1999
1TAQ	STRUCTURE OF TAQ DNA POLYMERASE Descriptor: 2-O-octyl-beta-D-glucopyranose, TAQ DNA POLYMERASE, ZINC ION Authors: Kim, Y, Eom, S.H, Wang, J, Lee, D.-S, Suh, S.W, Steitz, T.A. Deposit date: 1996-06-04 Release date: 1996-12-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of Thermus aquaticus DNA polymerase. Nature, 376, 1995
1U49	Adenine-8oxoguanine mismatch at the polymerase active site Descriptor: DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... Authors: Hsu, G.W, Ober, M, Carell, T, Beese, L.S. Deposit date: 2004-07-23 Release date: 2004-09-14 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
1U45	8oxoguanine at the pre-insertion site of the polymerase active site Descriptor: DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... Authors: Hsu, G.W, Ober, M, Carell, T, Beese, L.S. Deposit date: 2004-07-23 Release date: 2004-09-14 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
1U4B	Extension of an adenine-8oxoguanine mismatch Descriptor: DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... Authors: Hsu, G.W, Ober, M, Carell, T, Beese, L.S. Deposit date: 2004-07-23 Release date: 2004-09-14 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
1UA0	Aminofluorene DNA adduct at the pre-insertion site of a DNA polymerase Descriptor: 2-AMINOFLUORENE, DNA polymerase I, DNA primer strand, ... Authors: Hsu, G.W, Kiefer, J.R, Becherel, O.J, Fuchs, R.P.P, Beese, L.S. Deposit date: 2004-08-11 Release date: 2004-09-28 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase J.Biol.Chem., 279, 2004
1UA1	Structure of aminofluorene adduct paired opposite cytosine at the polymerase active site. Descriptor: 2-AMINOFLUORENE, DNA polymerase I, DNA primer strand, ... Authors: Hsu, G.W, Kiefer, J.R, Becherel, O.J, Fuchs, R.P.P, Beese, L.S. Deposit date: 2004-08-11 Release date: 2004-09-28 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase J.Biol.Chem., 279, 2004
1U47	cytosine-8-Oxoguanine base pair at the polymerase active site Descriptor: DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... Authors: Hsu, G.W, Ober, M, Carell, T, Beese, L.S. Deposit date: 2004-07-23 Release date: 2004-09-14 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
1U48	Extension of a cytosine-8-oxoguanine base pair Descriptor: DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... Authors: Hsu, G.W, Ober, M, Carell, T, Beese, L.S. Deposit date: 2004-07-23 Release date: 2004-09-14 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
1TAU	TAQ POLYMERASE (E.C.2.7.7.7)/DNA/B-OCTYLGLUCOSIDE COMPLEX Descriptor: 2-O-octyl-beta-D-glucopyranose, DNA (5'-D(*CP*GP*GP*AP*TP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*AP*TP*CP*CP*G)-3'), ... Authors: Eom, S.H, Wang, J, Steitz, T.A. Deposit date: 1996-06-17 Release date: 1997-04-18 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of Taq ploymerase with DNA at the polymerase active site. Nature, 382, 1996
4ELU	Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing modified pyrimidines Descriptor: 2'-deoxy-5-[(4-ethynylphenyl)ethynyl]cytidine 5'-(tetrahydrogen triphosphate), ACETATE ION, DNA (5'-D(*AP*AP*AP*GP*CP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... Authors: Marx, A, Diederichs, K, Obeid, S. Deposit date: 2012-04-11 Release date: 2013-03-27 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site. Chem.Commun.(Camb.), 48, 2012
4EZ9	Bacillus DNA Polymerase I Large Fragment Complex 2 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*GP*TP*CP*AP*GP*G)-3'), ... Authors: Wang, W, Beese, L.S. Deposit date: 2012-05-02 Release date: 2013-07-24 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Structures of a High-fidelity DNA Polymerase to be published
4F2S	DNA Polymerase I Large Fragment complex 4 Descriptor: CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*GP*GP*GP*AP*GP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DOC))-3'), ... Authors: Wang, W, Beese, L.S. Deposit date: 2012-05-08 Release date: 2013-07-24 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.651 Å) Cite: Structures of a High-fidelity DNA Polymerase to be published
4F3O	DNA Polymerase I Large Fragment Complex 5 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*C*AP*TP*GP*AP*GP*AP*GP*TP*CP*AP*GP*G)-3'), ... Authors: Wang, W, Beese, L.S. Deposit date: 2012-05-09 Release date: 2013-07-24 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Structures of a High-fidelity DNA Polymerase to be published
4F8R	Bacillus DNA Polymerase I Large Fragment complex 7 Descriptor: DNA (5'-D(*CP*AP*TP*TP*CP*GP*AP*GP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DDG))-3'), DNA polymerase, ... Authors: Wang, W, Beese, L.S. Deposit date: 2012-05-17 Release date: 2013-08-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Structures of a High-fidelity DNA Polymerase to be published
4DWI	Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with self complementary DNA, Se-dGTP and Calcium Descriptor: 9-METHYLGUANINE, CALCIUM ION, DNA (5'-D(*AP*CP*TP*GP*GP*AP*TP*CP*CP*A)-3'), ... Authors: Gan, J.H, Abdur, R, Liu, H.H, Sheng, J, Caton-Willians, J, Soares, A.S, Huang, Z. Deposit date: 2012-02-24 Release date: 2013-03-27 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase To be Published
4E0D	Binary complex of Bacillus DNA Polymerase I Large Fragment E658A and duplex DNA Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... Authors: Wang, W, Beese, L.S. Deposit date: 2012-03-02 Release date: 2012-06-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides. J.Biol.Chem., 287, 2012
4DFJ	Crystal structure of the large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with 5-(aminopentinyl)-dTTP Descriptor: 1,2-ETHANEDIOL, 5'-d(AAAAGGCGCCGTGGTC)-3', 5'-d(GACCACGGCGC DOC)-3', ... Authors: Bergen, K, Steck, A, Struett, S, Baccaro, A, Welte, W, Diederichs, K, Marx, A. Deposit date: 2012-01-23 Release date: 2012-05-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structures of KlenTaq DNA Polymerase Caught While Incorporating C5-Modified Pyrimidine and C7-Modified 7-Deazapurine Nucleoside Triphosphates. J.Am.Chem.Soc., 134, 2012
4DFK	large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with 5-(N-(10-hydroxydecanoyl)-aminopentinyl)-2-dUTP Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5-{5-[(10-hydroxydecanoyl)amino]pent-1-yn-1-yl}uridine 5'-(tetrahydrogen triphosphate), 5'-d(AAAAGGCGCCGTGGTC)-3', ... Authors: Bergen, K, Steck, A, Struett, S, Baccaro, A, Welte, W, Diederichs, K, Marx, A. Deposit date: 2012-01-24 Release date: 2012-05-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.647 Å) Cite: Structures of KlenTaq DNA Polymerase Caught While Incorporating C5-Modified Pyrimidine and C7-Modified 7-Deazapurine Nucleoside Triphosphates. J.Am.Chem.Soc., 134, 2012
4DLG	Ternary Structure of the large Fragment of Taq DNA polymerase Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, ACETATE ION, DNA polymerase I, ... Authors: Marx, A, Diederichs, K, Obeid, S, Holzberger, B. Deposit date: 2012-02-06 Release date: 2012-11-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Structural insights into the potential of 4-fluoroproline to modulate biophysical properties of protein Chem Sci, 3, 2012
4DFP	Crystal structure of the large fragment of DNA Polymerase I from Thermus aqauticus in a ternary complex with 7-(aminopentinyl)-7-deaza-dGTP Descriptor: 1,2-ETHANEDIOL, 2-amino-5-(5-aminopent-1-yn-1-yl)-7-{2-deoxy-5-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-erythro-pentofuranosyl}-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, 5'-d(AAACGGCGCCGTGGTC)-3', ... Authors: Bergen, K, Steck, A, Struett, S, Baccaro, A, Welte, W, Diederichs, K, Marx, A. Deposit date: 2012-01-24 Release date: 2012-05-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structures of KlenTaq DNA Polymerase Caught While Incorporating C5-Modified Pyrimidine and C7-Modified 7-Deazapurine Nucleoside Triphosphates. J.Am.Chem.Soc., 134, 2012
4DQQ	Ternary complex of Bacillus DNA Polymerase I Large Fragment E658A, DNA duplex, and rCTP (paired with dG of template) in presence of Mg2+ Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Wang, W, Beese, L.S. Deposit date: 2012-02-16 Release date: 2012-06-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.595 Å) Cite: Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides. J.Biol.Chem., 287, 2012

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