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2BUP
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BU of 2bup by Molmil
T13G Mutant of the ATPASE fragment of Bovine HSC70
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Sousa, M.C, Mckay, D.B.
Deposit date:1998-09-08
Release date:1998-09-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The hydroxyl of threonine 13 of the bovine 70-kDa heat shock cognate protein is essential for transducing the ATP-induced conformational change.
Biochemistry, 37, 1998
1DKY
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THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 2 NATIVE CRYSTALS
Descriptor: DNAK, PEPTIDE SUBSTRATE
Authors:Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A.
Deposit date:1996-06-03
Release date:1996-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural analysis of substrate binding by the molecular chaperone DnaK.
Science, 272, 1996
1DKX
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THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 SELENOMETHIONYL CRYSTALS
Descriptor: SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES)
Authors:Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A.
Deposit date:1996-06-03
Release date:1996-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of substrate binding by the molecular chaperone DnaK.
Science, 272, 1996
2E8A
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BU of 2e8a by Molmil
Crystal structure of the human Hsp70 ATPase domain in complex with AMP-PNP
Descriptor: Heat shock 70kDa protein 1A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-01-19
Release date:2008-01-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state.
Acta Crystallogr.,Sect.D, 66, 2010
3QNJ
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Crystal structure of the substrate binding domain of E.coli DnaK in complex with the antimicrobial peptide oncocin
Descriptor: Chaperone protein DnaK, SULFATE ION, antimicrobial peptide oncocin
Authors:Zahn, M, Straeter, N.
Deposit date:2011-02-08
Release date:2011-03-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK Complex.
Chembiochem, 12, 2011
3QFP
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BU of 3qfp by Molmil
Crystal structure of yeast Hsp70 (Bip/Kar2) ATPase domain
Descriptor: 78 kDa glucose-regulated protein homolog, PHOSPHATE ION
Authors:Yan, M, Li, J.Z, Sha, B.D.
Deposit date:2011-01-22
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor.
Biochem.J., 438, 2011
2E88
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BU of 2e88 by Molmil
Crystal structure of the human Hsp70 ATPase domain in the apo form
Descriptor: Heat shock 70kDa protein 1A, ZINC ION
Authors:Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-01-19
Release date:2008-01-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state.
Acta Crystallogr.,Sect.D, 66, 2010
3QFU
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BU of 3qfu by Molmil
Crystal structure of Yeast Hsp70 (Bip/kar2) complexed with ADP
Descriptor: 78 kDa glucose-regulated protein homolog, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Yan, M, Li, J.Z, Sha, B.D.
Deposit date:2011-01-22
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor.
Biochem.J., 438, 2011
4R5K
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BU of 4r5k by Molmil
Crystal structure of the DnaK C-terminus (Dnak-SBD-B)
Descriptor: CALCIUM ION, Chaperone protein DnaK, SULFATE ION
Authors:Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L.
Deposit date:2014-08-21
Release date:2014-09-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7469 Å)
Cite:Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
Acs Chem.Biol., 9, 2014
4R5J
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BU of 4r5j by Molmil
Crystal structure of the DnaK C-terminus (Dnak-SBD-A)
Descriptor: CALCIUM ION, Chaperone protein DnaK, PHOSPHATE ION
Authors:Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L.
Deposit date:2014-08-21
Release date:2014-09-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.361 Å)
Cite:Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
Acs Chem.Biol., 9, 2014
4R5L
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BU of 4r5l by Molmil
Crystal structure of the DnaK C-terminus (Dnak-SBD-C)
Descriptor: CALCIUM ION, Chaperone protein DnaK, PHOSPHATE ION, ...
Authors:Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L.
Deposit date:2014-08-21
Release date:2014-09-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9701 Å)
Cite:Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
Acs Chem.Biol., 9, 2014
4R5G
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BU of 4r5g by Molmil
Crystal structure of the DnaK C-terminus with the inhibitor PET-16
Descriptor: Chaperone protein DnaK, triphenyl(phenylethynyl)phosphonium
Authors:Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L.
Deposit date:2014-08-21
Release date:2014-09-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.4501 Å)
Cite:Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
Acs Chem.Biol., 9, 2014
4R5I
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BU of 4r5i by Molmil
Crystal structure of the DnaK C-terminus with the substrate peptide NRLLLTG
Descriptor: Chaperone protein DnaK, HSP70/DnaK Substrate Peptide: NRLLLTG, PHOSPHATE ION, ...
Authors:Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L.
Deposit date:2014-08-21
Release date:2014-09-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9702 Å)
Cite:Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket.
Acs Chem.Biol., 9, 2014
3ATV
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BU of 3atv by Molmil
Crystal structure of human Hsp70 NBD in the ADP-bound and Mg ion-free state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1A/1B, ...
Authors:Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2011-01-13
Release date:2011-12-28
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Biochemical and structural studies on the high affinity of Hsp70 for ADP.
Protein Sci., 20, 2011
3ATU
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BU of 3atu by Molmil
Crystal structure of human Hsp70 NBD in the ADP- and Mg ion-bound state
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A/1B, ...
Authors:Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2011-01-13
Release date:2011-12-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Biochemical and structural studies on the high affinity of Hsp70 for ADP.
Protein Sci., 20, 2011
3AY9
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BU of 3ay9 by Molmil
Crystal structure of human Hsp70 NBD in the ADP-, Mg ion-, and K ion-bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ...
Authors:Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2011-05-03
Release date:2011-12-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Biochemical and structural studies on the high affinity of Hsp70 for ADP.
Protein Sci., 20, 2011
3C7N
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BU of 3c7n by Molmil
Structure of the Hsp110:Hsc70 Nucleotide Exchange Complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, CHLORIDE ION, ...
Authors:Schuermann, J.P, Jiang, J, Hart, P.J, Sousa, R.
Deposit date:2008-02-07
Release date:2008-05-27
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.115 Å)
Cite:Structure of the Hsp110:Hsc70 nucleotide exchange machine
Mol.Cell, 31, 2008
3GL1
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BU of 3gl1 by Molmil
Crystal structure of ATPase domain of Ssb1 chaperone, a member of the HSP70 family, from Saccharomyces cerevisiae
Descriptor: CHLORIDE ION, GLYCEROL, Heat shock protein SSB1, ...
Authors:Osipiuk, J, Li, H, Bargassa, M, Sahi, C, Craig, E.A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2009-03-11
Release date:2009-03-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of ATPase domain of Ssb1 chaperone, member of the HSP70 family from Saccharomyces cerevisiae.
To be Published
3HSC
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BU of 3hsc by Molmil
THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 7OKD PROTEIN, MAGNESIUM ION, ...
Authors:Flaherty, K.M, Deluca-Flaherty, C.R, Mckay, D.B.
Deposit date:1995-03-24
Release date:1995-07-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein.
Nature, 346, 1990
1ATR
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BU of 1atr by Molmil
THREONINE 204 OF THE CHAPERONE PROTEIN HSC70 INFLUENCES THE STRUCTURE OF THE ACTIVE SITE BUT IS NOT ESSENTIAL FOR ATP HYDROLYSIS
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 70 KD PROTEIN, MAGNESIUM ION, ...
Authors:O'Brien, M.C, Mckay, D.B.
Deposit date:1993-08-09
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Threonine 204 of the chaperone protein Hsc70 influences the structure of the active site, but is not essential for ATP hydrolysis.
J.Biol.Chem., 268, 1993
1BA1
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BU of 1ba1 by Molmil
HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL MUTANT WITH CYS 17 REPLACED BY LYS
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HEAT-SHOCK COGNATE 70KD PROTEIN, ...
Authors:Wilbanks, S.M, Mckay, D.B.
Deposit date:1998-04-21
Release date:1998-07-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70.
Biochemistry, 37, 1998
1ATS
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BU of 1ats by Molmil
THREONINE 204 OF THE CHAPERONE PROTEIN HSC70 INFLUENCES THE STRUCTURE OF THE ACTIVE SITE BUT IS NOT ESSENTIAL FOR ATP HYDROLYSIS
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 70 KD PROTEIN, MAGNESIUM ION
Authors:O'Brien, M.C, Mckay, D.B.
Deposit date:1993-08-09
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Threonine 204 of the chaperone protein Hsc70 influences the structure of the active site, but is not essential for ATP hydrolysis.
J.Biol.Chem., 268, 1993
3IUC
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BU of 3iuc by Molmil
Crystal structure of the human 70kDa heat shock protein 5 (BiP/GRP78) ATPase domain in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70kDa protein 5 (Glucose-regulated protein, ...
Authors:Wisniewska, M, Karlberg, T, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotyenova, T, Kotzch, A, Kraulis, P, Markova, N, Moche, M, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A, Schutz, P, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC)
Deposit date:2009-08-31
Release date:2009-09-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78
Plos One, 5, 2010
1BA0
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HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL 1NGE 3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HEAT-SHOCK COGNATE 70KD PROTEIN, ...
Authors:Wilbanks, S.M, Mckay, D.B.
Deposit date:1998-04-21
Release date:1998-07-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70.
Biochemistry, 37, 1998
3GDQ
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BU of 3gdq by Molmil
Crystal structure of the human 70kDa heat shock protein 1-like ATPase domain in complex with ADP and inorganic phosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock 70 kDa protein 1-like, ...
Authors:Wisniewska, M, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Lehtio, L, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Schutz, P, Siponen, M, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Schueler, H, Structural Genomics Consortium (SGC)
Deposit date:2009-02-24
Release date:2009-04-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78
Plos One, 5, 2010

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