3VVI
 
 | |
3TE3
 | |
7D4Q
 | | Structure of human TRPC5 in complex with HC-070 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione, CALCIUM ION, ... | | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | | 登録日 | 2020-09-24 | | 公開日 | 2021-03-31 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
Elife, 10, 2021
|
|
7E4T
 | | Human TRPC5 apo state structure at 3 angstrom | | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... | | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | | 登録日 | 2021-02-15 | | 公開日 | 2021-03-31 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
Elife, 10, 2021
|
|
7D4P
 | | Structure of human TRPC5 in complex with clemizole | | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole, ... | | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | | 登録日 | 2020-09-24 | | 公開日 | 2021-03-31 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
Elife, 10, 2021
|
|
7DXB
 | | Structure of TRPC3 at 2.7 angstrom in high calcium state | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Chen, L, Guo, W. | | 登録日 | 2021-01-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
6DVZ
 | |
6DVW
 | |
6DVY
 | |
7DXF
 | |
7DXC
 | | Structure of TRPC3 at 3.06 angstrom in low calcium state | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, Short transient receptor potential channel 3, ... | | 著者 | Chen, L, Guo, W. | | 登録日 | 2021-01-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
7DXG
 | | Structure of SAR7334-bound TRPC6 at 2.9 angstrom | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[[(1R,2R)-2-[(3R)-3-azanylpiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloranyl-benzenecarbonitrile, CALCIUM ION, ... | | 著者 | Chen, L, Guo, W. | | 登録日 | 2021-01-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
7DXE
 | |
7DXD
 | |
6AYG
 | | Human Apo-TRPML3 channel at pH 4.8 | | 分子名称: | Mucolipin-3 | | 著者 | Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J. | | 登録日 | 2017-09-08 | | 公開日 | 2017-11-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.65 Å) | | 主引用文献 | Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
|
|
5YE2
 | |
5YE5
 | |
5YDZ
 | |
5K47
 | | CryoEM structure of the human Polycystin-2/PKD2 TRP channel | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | | 著者 | Pike, A.C.W, Grieben, M, Shintre, C.A, Tessitore, A, Shrestha, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | | 登録日 | 2016-05-20 | | 公開日 | 2016-08-24 | | 最終更新日 | 2020-10-21 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Nat. Struct. Mol. Biol., 24, 2017
|
|
1IAH
 | | CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (ADP-MG COMPLEX) | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Yamaguchi, H, Matsushita, M, Nairn, A.C, Kuriyan, J. | | 登録日 | 2001-03-22 | | 公開日 | 2001-06-06 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity.
Mol.Cell, 7, 2001
|
|
1IA9
 | | CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (AMPPNP COMPLEX) | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TRANSIENT RECEPTOR POTENTIAL-RELATED PROTEIN, ... | | 著者 | Yamaguchi, H, Matsushita, M, Nairn, A.C, Kuriyan, J. | | 登録日 | 2001-03-22 | | 公開日 | 2001-06-06 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity.
Mol.Cell, 7, 2001
|
|
1IAJ
 | | CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (APO) | | 分子名称: | TRANSIENT RECEPTOR POTENTIAL-RELATED PROTEIN, ZINC ION | | 著者 | Yamaguchi, H, Matsushita, M, Nairn, A.C, Kuriyan, J. | | 登録日 | 2001-03-22 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity.
Mol.Cell, 7, 2001
|
|
6UZA
 | | Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473 | | 分子名称: | 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Bai, Y, Yu, X, Huang, X, Chen, H. | | 登録日 | 2019-11-14 | | 公開日 | 2020-03-18 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Structural basis for pharmacological modulation of the TRPC6 channel.
Elife, 9, 2020
|
|
6UZ8
 | | Cryo-EM structure of human TRPC6 in complex with agonist AM-0883 | | 分子名称: | (5-chloro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone, 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Bai, Y, Yu, X, Huang, X, Chen, H. | | 登録日 | 2019-11-14 | | 公開日 | 2020-03-18 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Structural basis for pharmacological modulation of the TRPC6 channel.
Elife, 9, 2020
|
|
6PQP
 | | Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzylthioformamide, ... | | 著者 | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | | 登録日 | 2019-07-09 | | 公開日 | 2020-01-08 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Neuron, 105, 2020
|
|
