8PB1
| Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | 著者 | Felix, J, Bloch, Y, Savvides, S.N. | 登録日 | 2023-06-08 | 公開日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 2024
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8OE0
| Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2). | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | 著者 | Felix, J, Bloch, Y, Savvides, S.N. | 登録日 | 2023-03-10 | 公開日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 2024
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8ODZ
| Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1). | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | 著者 | Felix, J, Bloch, Y, Savvides, S.N. | 登録日 | 2023-03-10 | 公開日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 2024
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8CR6
| mouse Interleukin-12 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 subunit alpha, Interleukin-12 subunit beta, ... | 著者 | Merceron, R, Felix, J, Lambert, E, Bloch, Y, Savvides, S.N. | 登録日 | 2023-03-07 | 公開日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 2024
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3HMX
| Crystal structure of ustekinumab FAB/IL-12 complex | 分子名称: | Interleukin-12 subunit alpha, Interleukin-12 subunit beta, USTEKINUMAB FAB HEAVY CHAIN, ... | 著者 | Luo, J. | 登録日 | 2009-05-29 | 公開日 | 2010-06-09 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab. J.Mol.Biol., 402, 2010
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1F45
| HUMAN INTERLEUKIN-12 | 分子名称: | INTERLEUKIN-12 ALPHA CHAIN, INTERLEUKIN-12 BETA CHAIN, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yoon, C, Johnston, S.C, Tang, J, Tobin, J.F, Somers, W.S. | 登録日 | 2000-06-07 | 公開日 | 2001-06-20 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12. EMBO J., 19, 2000
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