Summary
| Title: | Cryo-EM structure of the C. neoformans lipid flippase Apt1-Cdc50 bound with butyrolactol A in the E2P state |
| Citation: | Chen, X.,Duan, H.D.,Hoy, M.J.,Koteva, K.,Spitzer, M.,Guitor, A.K.,Puumala, E.,Fiebig, A.A.,Hu, G.,Yiu, B.,Chou, S.,Bian, Z.,Choi, Y.,Guo, A.B.Y.,Wang, W.,Sun, S.,Robbins, N.,Averette, A.F.,Cook, M.A.,Truant, R.,MacNeil, L.T.,Brown, E.D.,Kronstad, J.W.,Coombes, B.K.,Cowen, L.E.,Heitman, J.,Li, H.,Wright, G.D. Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi. Cell, 2025 PubMed: 41478284DOI: 10.1016/j.cell.2025.11.036 |
| Experimental method: | ELECTRON MICROSCOPY |
| Deposition date: | 2024-10-17 |
| Release date: | 2025-02-05 |
| Obsoletion date: | 2026-01-14 |
| Obsoletion details: | Replaced by new entry |
Timeline
Downloads
| File format | File name (file size) | ||
| PDBx/mmCIF | 9dzu.cif.gz Display(320.58 KB) 9dzu.cif | ||
| PDBx/mmJSON | no-atom | 9dzu-noatom.json.gz Display (Header)(42.48 KB) 9dzu-noatom.json | |
| PDBML | all | 9dzu.xml.gz Display(426.95 KB) 9dzu.xml | |
| pdb_nextgen | all | pdb_00009dzu_xyz-enrich.cif.gz Display(351.07 KB) pdb_00009dzu_xyz-enrich.cif | |
| no-atom | pdb_00009dzu_xyz-no-atom-enrich.xml.gz Display(92.99 KB) pdb_00009dzu_xyz-no-atom-enrich.xml | ||
