Summary
| Title: | Crystal structure of GDP-bound KRAS G12D/I55E: Suppressing G12D oncogenicity via second-site I55E mutation |
| Citation: | Kwon, J.J.,Dilly, J.,Liu, S.,Kim, E.,Bian, Y.,Dharmaiah, S.,Tran, T.H.,Kapner, K.S.,Ly, S.H.,Yang, X.,Rabara, D.,Waybright, T.J.,Giacomelli, A.O.,Hong, A.L.,Misek, S.,Wang, B.,Ravi, A.,Doench, J.G.,Beroukhim, R.,Lemke, C.T.,Haigis, K.M.,Esposito, D.,Root, D.E.,Nissley, D.V.,Stephen, A.G.,McCormick, F.,Simanshu, D.K.,Hahn, W.C.,Aguirre, A.J. Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity. Biorxiv, 2024 PubMed: 39484452DOI: 10.1101/2024.10.22.618529 |
| Experimental method: | X-RAY DIFFRACTION (1.42 Å) |
| Deposition date: | 2024-06-01 |
| Release date: | 2025-10-08 |
| Obsoletion date: | 2026-03-25 |
Timeline
Downloads
| File format | File name (file size) | ||
| PDBx/mmCIF | 9c3l.cif.gz Display(231.19 KB) 9c3l.cif | ||
| PDBx/mmJSON | no-atom | 9c3l-noatom.json.gz Display (Header)(17.43 KB) 9c3l-noatom.json | |
| PDBML | all | 9c3l.xml.gz Display(318.53 KB) 9c3l.xml | |
| pdb_nextgen | all | pdb_00009c3l_xyz-enrich.cif.gz Display(244.08 KB) pdb_00009c3l_xyz-enrich.cif | |
| no-atom | pdb_00009c3l_xyz-no-atom-enrich.xml.gz Display(47.93 KB) pdb_00009c3l_xyz-no-atom-enrich.xml | ||
| PDB | pdb9c3l.ent.gz Display(183.97 KB) pdb9c3l.ent | ||
| Structure factors | r9c3lsf.ent.gz Display(952.57 KB) r9c3lsf.ent | ||
