Summary
| Title: | Crystal structure of RAR-related orphan receptor C (NHIS- RORgt(244-487)-L6-SRC1(678-692)) in complex with a phenyl (3-phenylpyrrolidin-3-yl)sulfone inhibitor |
| Citation: | Duan, J.J.W.,Lu, Z.,Jiang, B.,Stachura, S.,Weigelt, C.A.,Sack, J.S.,Khan, J.,Ruzanov, M.,Galella, M.A.,Wu, D.,Yarde, M.,Shen, D.,Shuster, D.J.,Borowski, V.,Xie, J.H.,Zhang, L.,Vanteru, S.,Gupta, A.K.,Mathur, A.,Zhao, Q.,Foster, W.,Salter-Cid, L.M.,Carter, P.H.,Dhar, T.G.M. Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORgammat Inverse Agonists Acs Med.Chem.Lett., 2019 DOI: 10.1021/acsmedchemlett.9b00010 |
| Experimental method: | X-RAY DIFFRACTION (1.9 Å) |
| Deposition date: | 2019-02-08 |
| Release date: | 2019-03-13 |
| Obsoletion date: | 2019-03-20 |
Timeline
Downloads
| File format | File name (file size) | ||
| PDBx/mmCIF | 6nxh.cif.gz Display(65.40 KB) 6nxh.cif | ||
| PDBx/mmJSON | no-atom | 6nxh-noatom.json.gz Display (Header)(12.93 KB) 6nxh-noatom.json | |
| PDBML | all | 6nxh.xml.gz Display(85.46 KB) 6nxh.xml | |
| PDB | pdb6nxh.ent.gz Display(50.56 KB) pdb6nxh.ent | ||
| Structure factors | r6nxhsf.ent.gz Display(262.04 KB) r6nxhsf.ent | ||
