Summary
| Title: | Discovery of a high affinity inhibitor of cGAS |
| Citation: | Hall, J.,Brault, A.,Vincent, F.,Weng, S.,Wang, H.,Dumlao, D.,Aulabaugh, A.,Aivazian, D.,Castro, D.,Chen, M.,Culp, J.,Dower, K.,Gardner, J.,Hawrylik, S.,Golenbock, D.,Hepworth, D.,Horn, M.,Jones, L.,Jones, P.,Latz, E.,Li, J.,Lin, L.L.,Lin, W.,Lin, D.,Lovering, F.,Niljanskul, N.,Nistler, R.,Pierce, B.,Plotnikova, O.,Schmitt, D.,Shanker, S.,Smith, J.,Snyder, W.,Subashi, T.,Trujillo, J.,Tyminski, E.,Wang, G.,Wong, J.,Lefker, B.,Dakin, L.,Leach, K. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE, 12:e0184843-e0184843, 2017 PubMed: 28934246DOI: 10.1371/journal.pone.0184843 |
| Experimental method: | X-RAY DIFFRACTION (3.23 Å) |
| Deposition date: | 2017-03-22 |
| Release date: | 2017-09-27 |
| Obsoletion date: | 2018-12-19 |
Timeline
Downloads
| File format | File name (file size) | ||
| PDBx/mmCIF | 5v8n.cif.gz Display(535.09 KB) 5v8n.cif | ||
| PDBML | all | 5v8n.xml.gz Display(722.03 KB) 5v8n.xml | |
| PDB | pdb5v8n.ent.gz Display(457.89 KB) pdb5v8n.ent | ||
| Structure factors | r5v8nsf.ent.gz Display(603.68 KB) r5v8nsf.ent | ||
