Summary
| Title: | Crystal structure of anaplastic lymphoma kinase (ALK) bound by brigatinib |
| Citation: | Huang, W.S.,Liu, S.,Zou, D.,Thomas, M.,Wang, Y.,Zhou, T.,Romero, J.,Kohlmann, A.,Li, F.,Qi, J.,Cai, L.,Dwight, T.A.,Xu, Y.,Xu, R.,Dodd, R.,Toms, A.,Parillon, L.,Lu, X.,Anjum, R.,Zhang, S.,Wang, F.,Keats, J.,Wardwell, S.D.,Ning, Y.,Xu, Q.,Moran, L.E.,Mohemmad, Q.K.,Jang, H.G.,Clackson, T.,Narasimhan, N.I.,Rivera, V.M.,Zhu, X.,Dalgarno, D.,Shakespeare, W.C. Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase. J.Med.Chem., 59:4948-4964, 2016 PubMed: 27144831DOI: 10.1021/acs.jmedchem.6b00306 |
| Experimental method: | X-RAY DIFFRACTION (1.96 Å) |
| Deposition date: | 2016-04-06 |
| Release date: | 2016-05-25 |
| Obsoletion date: | 2018-12-12 |
Timeline
Downloads
| File format | File name (file size) | ||
| PDBx/mmCIF | 5j7h.cif.gz Display(70.46 KB) 5j7h.cif | ||
| PDBML | all | 5j7h.xml.gz Display(90.77 KB) 5j7h.xml | |
| PDB | pdb5j7h.ent.gz Display(53.98 KB) pdb5j7h.ent | ||
| Structure factors | r5j7hsf.ent.gz Display(304.33 KB) r5j7hsf.ent | ||
