Summary
| Title: | Structure of the human GluN1/GluN2A LBD in complex with GNE0723 |
| Citation: | Volgraf, M.,Sellers, B.D.,Jiang, Y.,Wu, G.,Ly, C.Q.,Villemure, E.,Pastor, R.M.,Yuen, P.W.,Lu, A.,Luo, X.,Liu, M.,Zhang, S.,Sun, L.,Fu, Y.,Lupardus, P.J.,Wallweber, H.J.,Liederer, B.M.,Deshmukh, G.,Plise, E.,Tay, S.,Reynen, P.,Herrington, J.,Gustafson, A.,Liu, Y.,Dirksen, A.,Dietz, M.G.,Liu, Y.,Wang, T.M.,Hanson, J.E.,Hackos, D.,Scearce-Levie, K.,Schwarz, J.B. Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. J.Med.Chem., 59:2760-2779, 2016 PubMed: 26919761DOI: 10.1021/acs.jmedchem.5b02010 |
| Experimental method: | X-RAY DIFFRACTION (2.44 Å) |
| Deposition date: | 2016-02-09 |
| Release date: | 2016-03-16 |
| Obsoletion date: | 2016-07-13 |
Timeline
Downloads
| File format | File name (file size) | ||
| PDBx/mmCIF | 5i2j.cif.gz Display(126.35 KB) 5i2j.cif | ||
| PDBML | all | 5i2j.xml.gz Display(168.65 KB) 5i2j.xml | |
| PDB | pdb5i2j.ent.gz Display(100.43 KB) pdb5i2j.ent | ||
| Structure factors | r5i2jsf.ent.gz Display(500.25 KB) r5i2jsf.ent | ||
