9ZZR

Cryo-EM Structure of a RAD51 filament bound by ssDNA and the XRCC3-RAD51C-RAD51D-XRCC2 paralog complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000400	molecular_function	four-way junction DNA binding
B	0000722	biological_process	telomere maintenance via recombination
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000781	cellular_component	chromosome, telomeric region
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005657	cellular_component	replication fork
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0006281	biological_process	DNA repair
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0008821	molecular_function	crossover junction DNA endonuclease activity
B	0010824	biological_process	regulation of centrosome duplication
B	0031297	biological_process	replication fork processing
B	0033065	cellular_component	Rad51C-XRCC3 complex
B	0036297	biological_process	interstrand cross-link repair
B	0043596	cellular_component	nuclear replication fork
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0071140	biological_process	resolution of mitotic recombination intermediates
B	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
B	0090656	biological_process	t-circle formation
B	0090657	biological_process	telomeric loop disassembly
B	0090737	biological_process	telomere maintenance via telomere trimming
C	0000400	molecular_function	four-way junction DNA binding
C	0000707	biological_process	meiotic DNA recombinase assembly
C	0000722	biological_process	telomere maintenance via recombination
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005657	cellular_component	replication fork
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
C	0007062	biological_process	sister chromatid cohesion
C	0008821	molecular_function	crossover junction DNA endonuclease activity
C	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
C	0031297	biological_process	replication fork processing
C	0033063	cellular_component	Rad51B-Rad51C-Rad51D-XRCC2 complex
C	0033065	cellular_component	Rad51C-XRCC3 complex
C	0043596	cellular_component	nuclear replication fork
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0097435	biological_process	supramolecular fiber organization
D	0000400	molecular_function	four-way junction DNA binding
D	0000722	biological_process	telomere maintenance via recombination
D	0000723	biological_process	telomere maintenance
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000781	cellular_component	chromosome, telomeric region
D	0003677	molecular_function	DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005657	cellular_component	replication fork
D	0005813	cellular_component	centrosome
D	0005815	cellular_component	microtubule organizing center
D	0006281	biological_process	DNA repair
D	0007131	biological_process	reciprocal meiotic recombination
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0033063	cellular_component	Rad51B-Rad51C-Rad51D-XRCC2 complex
D	0042148	biological_process	DNA strand invasion
D	0043015	molecular_function	gamma-tubulin binding
D	0097435	biological_process	supramolecular fiber organization
D	0140664	molecular_function	ATP-dependent DNA damage sensor activity
E	0000150	molecular_function	DNA strand exchange activity
E	0000152	cellular_component	nuclear ubiquitin ligase complex
E	0000228	cellular_component	nuclear chromosome
E	0000722	biological_process	telomere maintenance via recombination
E	0000724	biological_process	double-strand break repair via homologous recombination
E	0000730	biological_process	DNA recombinase assembly
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0000793	cellular_component	condensed chromosome
E	0000794	cellular_component	condensed nuclear chromosome
E	0000800	cellular_component	lateral element
E	0003682	molecular_function	chromatin binding
E	0003690	molecular_function	double-stranded DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006310	biological_process	DNA recombination
E	0006312	biological_process	mitotic recombination
E	0006974	biological_process	DNA damage response
E	0007127	biological_process	meiosis I
E	0007131	biological_process	reciprocal meiotic recombination
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0009410	biological_process	response to xenobiotic stimulus
E	0009636	biological_process	response to toxic substance
E	0010165	biological_process	response to X-ray
E	0010569	biological_process	regulation of double-strand break repair via homologous recombination
E	0010833	biological_process	telomere maintenance via telomere lengthening
E	0016605	cellular_component	PML body
E	0016887	molecular_function	ATP hydrolysis activity
E	0019899	molecular_function	enzyme binding
E	0031297	biological_process	replication fork processing
E	0031491	molecular_function	nucleosome binding
E	0032991	cellular_component	protein-containing complex
E	0032993	cellular_component	protein-DNA complex
E	0035861	cellular_component	site of double-strand break
E	0036297	biological_process	interstrand cross-link repair
E	0042148	biological_process	DNA strand invasion
E	0042802	molecular_function	identical protein binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051321	biological_process	meiotic cell cycle
E	0070182	molecular_function	DNA polymerase binding
E	0070192	biological_process	chromosome organization involved in meiotic cell cycle
E	0071479	biological_process	cellular response to ionizing radiation
E	0071480	biological_process	cellular response to gamma radiation
E	0072719	biological_process	cellular response to cisplatin
E	0072757	biological_process	cellular response to camptothecin
E	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
E	1904631	biological_process	response to glucoside
E	1990918	biological_process	double-strand break repair involved in meiotic recombination
E	2000001	biological_process	regulation of DNA damage checkpoint
F	0000150	molecular_function	DNA strand exchange activity
F	0000152	cellular_component	nuclear ubiquitin ligase complex
F	0000228	cellular_component	nuclear chromosome
F	0000722	biological_process	telomere maintenance via recombination
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0000730	biological_process	DNA recombinase assembly
F	0000781	cellular_component	chromosome, telomeric region
F	0000785	cellular_component	chromatin
F	0000793	cellular_component	condensed chromosome
F	0000794	cellular_component	condensed nuclear chromosome
F	0000800	cellular_component	lateral element
F	0003682	molecular_function	chromatin binding
F	0003690	molecular_function	double-stranded DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0006281	biological_process	DNA repair
F	0006310	biological_process	DNA recombination
F	0006312	biological_process	mitotic recombination
F	0006974	biological_process	DNA damage response
F	0007127	biological_process	meiosis I
F	0007131	biological_process	reciprocal meiotic recombination
F	0008094	molecular_function	ATP-dependent activity, acting on DNA
F	0009410	biological_process	response to xenobiotic stimulus
F	0009636	biological_process	response to toxic substance
F	0010165	biological_process	response to X-ray
F	0010569	biological_process	regulation of double-strand break repair via homologous recombination
F	0010833	biological_process	telomere maintenance via telomere lengthening
F	0016605	cellular_component	PML body
F	0016887	molecular_function	ATP hydrolysis activity
F	0019899	molecular_function	enzyme binding
F	0031297	biological_process	replication fork processing
F	0031491	molecular_function	nucleosome binding
F	0032991	cellular_component	protein-containing complex
F	0032993	cellular_component	protein-DNA complex
F	0035861	cellular_component	site of double-strand break
F	0036297	biological_process	interstrand cross-link repair
F	0042148	biological_process	DNA strand invasion
F	0042802	molecular_function	identical protein binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0051321	biological_process	meiotic cell cycle
F	0070182	molecular_function	DNA polymerase binding
F	0070192	biological_process	chromosome organization involved in meiotic cell cycle
F	0071479	biological_process	cellular response to ionizing radiation
F	0071480	biological_process	cellular response to gamma radiation
F	0072719	biological_process	cellular response to cisplatin
F	0072757	biological_process	cellular response to camptothecin
F	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
F	1904631	biological_process	response to glucoside
F	1990918	biological_process	double-strand break repair involved in meiotic recombination
F	2000001	biological_process	regulation of DNA damage checkpoint
K	0000150	molecular_function	DNA strand exchange activity
K	0000152	cellular_component	nuclear ubiquitin ligase complex
K	0000228	cellular_component	nuclear chromosome
K	0000722	biological_process	telomere maintenance via recombination
K	0000724	biological_process	double-strand break repair via homologous recombination
K	0000730	biological_process	DNA recombinase assembly
K	0000781	cellular_component	chromosome, telomeric region
K	0000785	cellular_component	chromatin
K	0000793	cellular_component	condensed chromosome
K	0000794	cellular_component	condensed nuclear chromosome
K	0000800	cellular_component	lateral element
K	0003682	molecular_function	chromatin binding
K	0003690	molecular_function	double-stranded DNA binding
K	0003697	molecular_function	single-stranded DNA binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005730	cellular_component	nucleolus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0006281	biological_process	DNA repair
K	0006310	biological_process	DNA recombination
K	0006312	biological_process	mitotic recombination
K	0006974	biological_process	DNA damage response
K	0007127	biological_process	meiosis I
K	0007131	biological_process	reciprocal meiotic recombination
K	0008094	molecular_function	ATP-dependent activity, acting on DNA
K	0009410	biological_process	response to xenobiotic stimulus
K	0009636	biological_process	response to toxic substance
K	0010165	biological_process	response to X-ray
K	0010569	biological_process	regulation of double-strand break repair via homologous recombination
K	0010833	biological_process	telomere maintenance via telomere lengthening
K	0016605	cellular_component	PML body
K	0016887	molecular_function	ATP hydrolysis activity
K	0019899	molecular_function	enzyme binding
K	0031297	biological_process	replication fork processing
K	0031491	molecular_function	nucleosome binding
K	0032991	cellular_component	protein-containing complex
K	0032993	cellular_component	protein-DNA complex
K	0035861	cellular_component	site of double-strand break
K	0036297	biological_process	interstrand cross-link repair
K	0042148	biological_process	DNA strand invasion
K	0042802	molecular_function	identical protein binding
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0051321	biological_process	meiotic cell cycle
K	0070182	molecular_function	DNA polymerase binding
K	0070192	biological_process	chromosome organization involved in meiotic cell cycle
K	0071479	biological_process	cellular response to ionizing radiation
K	0071480	biological_process	cellular response to gamma radiation
K	0072719	biological_process	cellular response to cisplatin
K	0072757	biological_process	cellular response to camptothecin
K	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
K	1904631	biological_process	response to glucoside
K	1990918	biological_process	double-strand break repair involved in meiotic recombination
K	2000001	biological_process	regulation of DNA damage checkpoint
O	0000150	molecular_function	DNA strand exchange activity
O	0000152	cellular_component	nuclear ubiquitin ligase complex
O	0000228	cellular_component	nuclear chromosome
O	0000722	biological_process	telomere maintenance via recombination
O	0000724	biological_process	double-strand break repair via homologous recombination
O	0000730	biological_process	DNA recombinase assembly
O	0000781	cellular_component	chromosome, telomeric region
O	0000785	cellular_component	chromatin
O	0000793	cellular_component	condensed chromosome
O	0000794	cellular_component	condensed nuclear chromosome
O	0000800	cellular_component	lateral element
O	0003682	molecular_function	chromatin binding
O	0003690	molecular_function	double-stranded DNA binding
O	0003697	molecular_function	single-stranded DNA binding
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0005730	cellular_component	nucleolus
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005759	cellular_component	mitochondrial matrix
O	0005813	cellular_component	centrosome
O	0005829	cellular_component	cytosol
O	0006281	biological_process	DNA repair
O	0006310	biological_process	DNA recombination
O	0006312	biological_process	mitotic recombination
O	0006974	biological_process	DNA damage response
O	0007127	biological_process	meiosis I
O	0007131	biological_process	reciprocal meiotic recombination
O	0008094	molecular_function	ATP-dependent activity, acting on DNA
O	0009410	biological_process	response to xenobiotic stimulus
O	0009636	biological_process	response to toxic substance
O	0010165	biological_process	response to X-ray
O	0010569	biological_process	regulation of double-strand break repair via homologous recombination
O	0010833	biological_process	telomere maintenance via telomere lengthening
O	0016605	cellular_component	PML body
O	0016887	molecular_function	ATP hydrolysis activity
O	0019899	molecular_function	enzyme binding
O	0031297	biological_process	replication fork processing
O	0031491	molecular_function	nucleosome binding
O	0032991	cellular_component	protein-containing complex
O	0032993	cellular_component	protein-DNA complex
O	0035861	cellular_component	site of double-strand break
O	0036297	biological_process	interstrand cross-link repair
O	0042148	biological_process	DNA strand invasion
O	0042802	molecular_function	identical protein binding
O	0048471	cellular_component	perinuclear region of cytoplasm
O	0051321	biological_process	meiotic cell cycle
O	0070182	molecular_function	DNA polymerase binding
O	0070192	biological_process	chromosome organization involved in meiotic cell cycle
O	0071479	biological_process	cellular response to ionizing radiation
O	0071480	biological_process	cellular response to gamma radiation
O	0072719	biological_process	cellular response to cisplatin
O	0072757	biological_process	cellular response to camptothecin
O	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
O	1904631	biological_process	response to glucoside
O	1990918	biological_process	double-strand break repair involved in meiotic recombination
O	2000001	biological_process	regulation of DNA damage checkpoint
R	0000150	molecular_function	DNA strand exchange activity
R	0000152	cellular_component	nuclear ubiquitin ligase complex
R	0000228	cellular_component	nuclear chromosome
R	0000722	biological_process	telomere maintenance via recombination
R	0000724	biological_process	double-strand break repair via homologous recombination
R	0000730	biological_process	DNA recombinase assembly
R	0000781	cellular_component	chromosome, telomeric region
R	0000785	cellular_component	chromatin
R	0000793	cellular_component	condensed chromosome
R	0000794	cellular_component	condensed nuclear chromosome
R	0000800	cellular_component	lateral element
R	0003682	molecular_function	chromatin binding
R	0003690	molecular_function	double-stranded DNA binding
R	0003697	molecular_function	single-stranded DNA binding
R	0005515	molecular_function	protein binding
R	0005524	molecular_function	ATP binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0005730	cellular_component	nucleolus
R	0005737	cellular_component	cytoplasm
R	0005739	cellular_component	mitochondrion
R	0005759	cellular_component	mitochondrial matrix
R	0005813	cellular_component	centrosome
R	0005829	cellular_component	cytosol
R	0006281	biological_process	DNA repair
R	0006310	biological_process	DNA recombination
R	0006312	biological_process	mitotic recombination
R	0006974	biological_process	DNA damage response
R	0007127	biological_process	meiosis I
R	0007131	biological_process	reciprocal meiotic recombination
R	0008094	molecular_function	ATP-dependent activity, acting on DNA
R	0009410	biological_process	response to xenobiotic stimulus
R	0009636	biological_process	response to toxic substance
R	0010165	biological_process	response to X-ray
R	0010569	biological_process	regulation of double-strand break repair via homologous recombination
R	0010833	biological_process	telomere maintenance via telomere lengthening
R	0016605	cellular_component	PML body
R	0016887	molecular_function	ATP hydrolysis activity
R	0019899	molecular_function	enzyme binding
R	0031297	biological_process	replication fork processing
R	0031491	molecular_function	nucleosome binding
R	0032991	cellular_component	protein-containing complex
R	0032993	cellular_component	protein-DNA complex
R	0035861	cellular_component	site of double-strand break
R	0036297	biological_process	interstrand cross-link repair
R	0042148	biological_process	DNA strand invasion
R	0042802	molecular_function	identical protein binding
R	0048471	cellular_component	perinuclear region of cytoplasm
R	0051321	biological_process	meiotic cell cycle
R	0070182	molecular_function	DNA polymerase binding
R	0070192	biological_process	chromosome organization involved in meiotic cell cycle
R	0071479	biological_process	cellular response to ionizing radiation
R	0071480	biological_process	cellular response to gamma radiation
R	0072719	biological_process	cellular response to cisplatin
R	0072757	biological_process	cellular response to camptothecin
R	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
R	1904631	biological_process	response to glucoside
R	1990918	biological_process	double-strand break repair involved in meiotic recombination
R	2000001	biological_process	regulation of DNA damage checkpoint
V	0000150	molecular_function	DNA strand exchange activity
V	0000152	cellular_component	nuclear ubiquitin ligase complex
V	0000228	cellular_component	nuclear chromosome
V	0000722	biological_process	telomere maintenance via recombination
V	0000724	biological_process	double-strand break repair via homologous recombination
V	0000730	biological_process	DNA recombinase assembly
V	0000781	cellular_component	chromosome, telomeric region
V	0000785	cellular_component	chromatin
V	0000793	cellular_component	condensed chromosome
V	0000794	cellular_component	condensed nuclear chromosome
V	0000800	cellular_component	lateral element
V	0003682	molecular_function	chromatin binding
V	0003690	molecular_function	double-stranded DNA binding
V	0003697	molecular_function	single-stranded DNA binding
V	0005515	molecular_function	protein binding
V	0005524	molecular_function	ATP binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005694	cellular_component	chromosome
V	0005730	cellular_component	nucleolus
V	0005737	cellular_component	cytoplasm
V	0005739	cellular_component	mitochondrion
V	0005759	cellular_component	mitochondrial matrix
V	0005813	cellular_component	centrosome
V	0005829	cellular_component	cytosol
V	0006281	biological_process	DNA repair
V	0006310	biological_process	DNA recombination
V	0006312	biological_process	mitotic recombination
V	0006974	biological_process	DNA damage response
V	0007127	biological_process	meiosis I
V	0007131	biological_process	reciprocal meiotic recombination
V	0008094	molecular_function	ATP-dependent activity, acting on DNA
V	0009410	biological_process	response to xenobiotic stimulus
V	0009636	biological_process	response to toxic substance
V	0010165	biological_process	response to X-ray
V	0010569	biological_process	regulation of double-strand break repair via homologous recombination
V	0010833	biological_process	telomere maintenance via telomere lengthening
V	0016605	cellular_component	PML body
V	0016887	molecular_function	ATP hydrolysis activity
V	0019899	molecular_function	enzyme binding
V	0031297	biological_process	replication fork processing
V	0031491	molecular_function	nucleosome binding
V	0032991	cellular_component	protein-containing complex
V	0032993	cellular_component	protein-DNA complex
V	0035861	cellular_component	site of double-strand break
V	0036297	biological_process	interstrand cross-link repair
V	0042148	biological_process	DNA strand invasion
V	0042802	molecular_function	identical protein binding
V	0048471	cellular_component	perinuclear region of cytoplasm
V	0051321	biological_process	meiotic cell cycle
V	0070182	molecular_function	DNA polymerase binding
V	0070192	biological_process	chromosome organization involved in meiotic cell cycle
V	0071479	biological_process	cellular response to ionizing radiation
V	0071480	biological_process	cellular response to gamma radiation
V	0072719	biological_process	cellular response to cisplatin
V	0072757	biological_process	cellular response to camptothecin
V	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
V	1904631	biological_process	response to glucoside
V	1990918	biological_process	double-strand break repair involved in meiotic recombination
V	2000001	biological_process	regulation of DNA damage checkpoint
W	0000150	molecular_function	DNA strand exchange activity
W	0000152	cellular_component	nuclear ubiquitin ligase complex
W	0000228	cellular_component	nuclear chromosome
W	0000722	biological_process	telomere maintenance via recombination
W	0000724	biological_process	double-strand break repair via homologous recombination
W	0000730	biological_process	DNA recombinase assembly
W	0000781	cellular_component	chromosome, telomeric region
W	0000785	cellular_component	chromatin
W	0000793	cellular_component	condensed chromosome
W	0000794	cellular_component	condensed nuclear chromosome
W	0000800	cellular_component	lateral element
W	0003682	molecular_function	chromatin binding
W	0003690	molecular_function	double-stranded DNA binding
W	0003697	molecular_function	single-stranded DNA binding
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005694	cellular_component	chromosome
W	0005730	cellular_component	nucleolus
W	0005737	cellular_component	cytoplasm
W	0005739	cellular_component	mitochondrion
W	0005759	cellular_component	mitochondrial matrix
W	0005813	cellular_component	centrosome
W	0005829	cellular_component	cytosol
W	0006281	biological_process	DNA repair
W	0006310	biological_process	DNA recombination
W	0006312	biological_process	mitotic recombination
W	0006974	biological_process	DNA damage response
W	0007127	biological_process	meiosis I
W	0007131	biological_process	reciprocal meiotic recombination
W	0008094	molecular_function	ATP-dependent activity, acting on DNA
W	0009410	biological_process	response to xenobiotic stimulus
W	0009636	biological_process	response to toxic substance
W	0010165	biological_process	response to X-ray
W	0010569	biological_process	regulation of double-strand break repair via homologous recombination
W	0010833	biological_process	telomere maintenance via telomere lengthening
W	0016605	cellular_component	PML body
W	0016887	molecular_function	ATP hydrolysis activity
W	0019899	molecular_function	enzyme binding
W	0031297	biological_process	replication fork processing
W	0031491	molecular_function	nucleosome binding
W	0032991	cellular_component	protein-containing complex
W	0032993	cellular_component	protein-DNA complex
W	0035861	cellular_component	site of double-strand break
W	0036297	biological_process	interstrand cross-link repair
W	0042148	biological_process	DNA strand invasion
W	0042802	molecular_function	identical protein binding
W	0048471	cellular_component	perinuclear region of cytoplasm
W	0051321	biological_process	meiotic cell cycle
W	0070182	molecular_function	DNA polymerase binding
W	0070192	biological_process	chromosome organization involved in meiotic cell cycle
W	0071479	biological_process	cellular response to ionizing radiation
W	0071480	biological_process	cellular response to gamma radiation
W	0072719	biological_process	cellular response to cisplatin
W	0072757	biological_process	cellular response to camptothecin
W	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
W	1904631	biological_process	response to glucoside
W	1990918	biological_process	double-strand break repair involved in meiotic recombination
W	2000001	biological_process	regulation of DNA damage checkpoint
X	0000278	biological_process	mitotic cell cycle
X	0000400	molecular_function	four-way junction DNA binding
X	0000724	biological_process	double-strand break repair via homologous recombination
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005657	cellular_component	replication fork
X	0005813	cellular_component	centrosome
X	0006281	biological_process	DNA repair
X	0007098	biological_process	centrosome cycle
X	0033063	cellular_component	Rad51B-Rad51C-Rad51D-XRCC2 complex
X	0042148	biological_process	DNA strand invasion
X	0051321	biological_process	meiotic cell cycle
X	0097435	biological_process	supramolecular fiber organization

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	203
Details	Domain: {"description":"HhH"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	511
Details	Region: {"description":"Interaction with PALB2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	105
Details	Motif: {"description":"Nuclear export signal; masked by the interaction with BRCA2","evidences":[{"source":"PubMed","id":"24013206","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	70
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507080","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5NWL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"9461559","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Modified residue: {"description":"Phosphothreonine; by CHEK1","evidences":[{"source":"PubMed","id":"15665856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	21
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23393192","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	21
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---