Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9ZUN

Structural insights into the exosite-mediated activation of Factor IX by Factor XIa using cryoEM

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDdinsYeCwC

Chain	Residue	Details
C	CYS62-CYS73

site_id	PS00011
Number of Residues	26
Details	GLA_1 Vitamin K-dependent carboxylation domain. EcmEEkCsfeearEvfentertte.FW

Chain	Residue	Details
C	CGU17-TRP42

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CwCpfGfeGKnC

Chain	Residue	Details
C	CYS71-CYS82

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
B	LEU409-CYS414
C	VAL217-CYS222

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPHV

Chain	Residue	Details
C	ASP359-VAL370

site_id	PS00495
Number of Residues	84
Details	APPLE Apple domain. CvtqLlkdtcFeggDIttvftpsakyCqvvCTyhprClLFtFtaespsedptrwftCvLKdSvtetlprvnrtaai.SGySFkqC

Chain	Residue	Details
A	CYS2-CYS85
A	CYS92-CYS175
A	CYS182-CYS265
A	CYS273-CYS356

site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CwCpfGFegkn....C

Chain	Residue	Details
C	CYS71-CYS82
C	CYS109-CYS124

site_id	PS01187
Number of Residues	25
Details	EGF_CA Calcium-binding EGF-like domain signature. DgDQCesnp..........Clnggs..CkDdinsYeC

Chain	Residue	Details
C	ASP47-CYS71

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	83
Details	Domain: {"description":"Apple 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00315","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	83
Details	Domain: {"description":"Apple 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00315","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	83
Details	Domain: {"description":"Apple 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00315","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	83
Details	Domain: {"description":"Apple 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00315","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine; atypical","evidences":[{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	235
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1998667","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	34
Details	Propeptide: {"description":"Activation peptide","featureId":"PRO_0000027758"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	36
Details	Domain: {"description":"EGF-like 1; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"20004170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"659613","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"659613","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7606779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EDM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10467148","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20004170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20080729","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121198","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1RFN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10467148","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20004170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20080729","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121198","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WPH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KCG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LC5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Site: {"description":"Cleavage; by factor XIa"}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"(3R)-3-hydroxyaspartate","evidences":[{"source":"PubMed","id":"6688526","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"book","publicationDate":"1996","firstPage":"50","lastPage":"50","publisher":"Annecy","bookName":"Proceedings of XIth international conference on methods in protein structure analysis","title":"Partial phosphorylation of serine-68 in EGF-1 of human factor IX.","authors":["Harris R.J.","Papac D.I.","Truong L.","Smith K.J."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"Sulfotyrosine","evidences":[{"source":"PubMed","id":"11133752","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"11133752","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25456591","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; alternate","evidences":[{"source":"PubMed","id":"25456591","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (Glc...) serine","featureId":"CAR_000009","evidences":[{"source":"PubMed","id":"2129367","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2511201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25456591","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (Fuc...) serine","featureId":"CAR_000010","evidences":[{"source":"PubMed","id":"1517205","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25456591","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine; alternate","evidences":[{"source":"PubMed","id":"25456591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8172892","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"25456591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8172892","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"25456591","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)