9ZKW

The LBD-TMD structure of native mouse AMPAR with 3 TARPs

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0005245	molecular_function	voltage-gated calcium channel activity
E	0005515	molecular_function	protein binding
E	0006612	biological_process	protein targeting to membrane
E	0007528	biological_process	neuromuscular junction development
E	0009986	cellular_component	cell surface
E	0016020	cellular_component	membrane
E	0016247	molecular_function	channel regulator activity
E	0019226	biological_process	transmission of nerve impulse
E	0032281	cellular_component	AMPA glutamate receptor complex
E	0035255	molecular_function	ionotropic glutamate receptor binding
E	0036477	cellular_component	somatodendritic compartment
E	0042391	biological_process	regulation of membrane potential
E	0044300	cellular_component	cerebellar mossy fiber
E	0045202	cellular_component	synapse
E	0050877	biological_process	nervous system process
E	0051592	biological_process	response to calcium ion
E	0051899	biological_process	membrane depolarization
E	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
E	0060081	biological_process	membrane hyperpolarization
E	0060082	biological_process	eye blink reflex
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
E	0098839	cellular_component	postsynaptic density membrane
E	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
E	0098978	cellular_component	glutamatergic synapse
E	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
E	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
E	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
E	2000311	biological_process	regulation of AMPA receptor activity
E	2000969	biological_process	positive regulation of AMPA receptor activity
G	0005245	molecular_function	voltage-gated calcium channel activity
G	0005246	molecular_function	calcium channel regulator activity
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0014069	cellular_component	postsynaptic density
G	0016247	molecular_function	channel regulator activity
G	0019226	biological_process	transmission of nerve impulse
G	0030346	molecular_function	protein phosphatase 2B binding
G	0032281	cellular_component	AMPA glutamate receptor complex
G	0032590	cellular_component	dendrite membrane
G	0035255	molecular_function	ionotropic glutamate receptor binding
G	0045202	cellular_component	synapse
G	0045211	cellular_component	postsynaptic membrane
G	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
G	0070588	biological_process	calcium ion transmembrane transport
G	0098685	cellular_component	Schaffer collateral - CA1 synapse
G	0098839	cellular_component	postsynaptic density membrane
G	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
G	0098978	cellular_component	glutamatergic synapse
G	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
G	1990454	cellular_component	L-type voltage-gated calcium channel complex
G	2000311	biological_process	regulation of AMPA receptor activity
G	2000969	biological_process	positive regulation of AMPA receptor activity
H	0005245	molecular_function	voltage-gated calcium channel activity
H	0005246	molecular_function	calcium channel regulator activity
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0014069	cellular_component	postsynaptic density
H	0016247	molecular_function	channel regulator activity
H	0019226	biological_process	transmission of nerve impulse
H	0030346	molecular_function	protein phosphatase 2B binding
H	0032281	cellular_component	AMPA glutamate receptor complex
H	0032590	cellular_component	dendrite membrane
H	0035255	molecular_function	ionotropic glutamate receptor binding
H	0045202	cellular_component	synapse
H	0045211	cellular_component	postsynaptic membrane
H	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
H	0070588	biological_process	calcium ion transmembrane transport
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098839	cellular_component	postsynaptic density membrane
H	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
H	0098978	cellular_component	glutamatergic synapse
H	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
H	1990454	cellular_component	L-type voltage-gated calcium channel complex
H	2000311	biological_process	regulation of AMPA receptor activity
H	2000969	biological_process	positive regulation of AMPA receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	Intramembrane: {"description":"Helical; Pore-forming","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Intramembrane: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	348
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=M4","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P42262","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P19490","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"16129400","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---