Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9ZKS

The LBD-TMD structure of native mouse AMPAR with 2 TARPs 2 CNIHs and PRRT1/SynDIG4

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0005515	molecular_function	protein binding
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0014069	cellular_component	postsynaptic density
E	0016247	molecular_function	channel regulator activity
E	0030425	cellular_component	dendrite
E	0032281	cellular_component	AMPA glutamate receptor complex
E	0035249	biological_process	synaptic transmission, glutamatergic
E	0038024	molecular_function	cargo receptor activity
E	0042391	biological_process	regulation of membrane potential
E	0043197	cellular_component	dendritic spine
E	0043198	cellular_component	dendritic shaft
E	0045202	cellular_component	synapse
E	0045211	cellular_component	postsynaptic membrane
E	0051668	biological_process	localization within membrane
E	0098839	cellular_component	postsynaptic density membrane
E	0098978	cellular_component	glutamatergic synapse
E	1902684	biological_process	negative regulation of receptor localization to synapse
E	1903743	biological_process	negative regulation of anterograde synaptic vesicle transport
E	2000310	biological_process	regulation of NMDA receptor activity
E	2000311	biological_process	regulation of AMPA receptor activity
F	0005515	molecular_function	protein binding
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0014069	cellular_component	postsynaptic density
F	0016247	molecular_function	channel regulator activity
F	0030425	cellular_component	dendrite
F	0032281	cellular_component	AMPA glutamate receptor complex
F	0035249	biological_process	synaptic transmission, glutamatergic
F	0038024	molecular_function	cargo receptor activity
F	0042391	biological_process	regulation of membrane potential
F	0043197	cellular_component	dendritic spine
F	0043198	cellular_component	dendritic shaft
F	0045202	cellular_component	synapse
F	0045211	cellular_component	postsynaptic membrane
F	0051668	biological_process	localization within membrane
F	0098839	cellular_component	postsynaptic density membrane
F	0098978	cellular_component	glutamatergic synapse
F	1902684	biological_process	negative regulation of receptor localization to synapse
F	1903743	biological_process	negative regulation of anterograde synaptic vesicle transport
F	2000310	biological_process	regulation of NMDA receptor activity
F	2000311	biological_process	regulation of AMPA receptor activity
G	0005245	molecular_function	voltage-gated calcium channel activity
G	0005246	molecular_function	calcium channel regulator activity
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0014069	cellular_component	postsynaptic density
G	0016247	molecular_function	channel regulator activity
G	0019226	biological_process	transmission of nerve impulse
G	0030346	molecular_function	protein phosphatase 2B binding
G	0032281	cellular_component	AMPA glutamate receptor complex
G	0032590	cellular_component	dendrite membrane
G	0035255	molecular_function	ionotropic glutamate receptor binding
G	0045202	cellular_component	synapse
G	0045211	cellular_component	postsynaptic membrane
G	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
G	0070588	biological_process	calcium ion transmembrane transport
G	0098685	cellular_component	Schaffer collateral - CA1 synapse
G	0098839	cellular_component	postsynaptic density membrane
G	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
G	0098978	cellular_component	glutamatergic synapse
G	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
G	1990454	cellular_component	L-type voltage-gated calcium channel complex
G	2000311	biological_process	regulation of AMPA receptor activity
G	2000969	biological_process	positive regulation of AMPA receptor activity
H	0005245	molecular_function	voltage-gated calcium channel activity
H	0005246	molecular_function	calcium channel regulator activity
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0014069	cellular_component	postsynaptic density
H	0016247	molecular_function	channel regulator activity
H	0019226	biological_process	transmission of nerve impulse
H	0030346	molecular_function	protein phosphatase 2B binding
H	0032281	cellular_component	AMPA glutamate receptor complex
H	0032590	cellular_component	dendrite membrane
H	0035255	molecular_function	ionotropic glutamate receptor binding
H	0045202	cellular_component	synapse
H	0045211	cellular_component	postsynaptic membrane
H	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
H	0070588	biological_process	calcium ion transmembrane transport
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098839	cellular_component	postsynaptic density membrane
H	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
H	0098978	cellular_component	glutamatergic synapse
H	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
H	1990454	cellular_component	L-type voltage-gated calcium channel complex
H	2000311	biological_process	regulation of AMPA receptor activity
H	2000969	biological_process	positive regulation of AMPA receptor activity
M	0005886	cellular_component	plasma membrane
M	0006468	biological_process	protein phosphorylation
M	0007611	biological_process	learning or memory
M	0008104	biological_process	intracellular protein localization
M	0030545	molecular_function	signaling receptor regulator activity
M	0030672	cellular_component	synaptic vesicle membrane
M	0034394	biological_process	protein localization to cell surface
M	0042802	molecular_function	identical protein binding
M	0045202	cellular_component	synapse
M	0045211	cellular_component	postsynaptic membrane
M	0050808	biological_process	synapse organization
M	0060291	biological_process	long-term synaptic potentiation
M	0060292	biological_process	long-term synaptic depression
M	0098839	cellular_component	postsynaptic density membrane
M	0098978	cellular_component	glutamatergic synapse
M	2000311	biological_process	regulation of AMPA receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	30
Details	Intramembrane: {"description":"Helical; Pore-forming","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Intramembrane: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	10
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	348
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=M4","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P42262","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P19490","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"16129400","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	280
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	20
Details	Intramembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)