9ZCZ
C4 local refinement of stomatin-bound aquaporin (human)
Functional Information from PROSITE/UniProt
| site_id | PS00221 |
| Number of Residues | 9 |
| Details | MIP MIP family signature. HLNPAVTLG |
| Chain | Residue | Details |
| D | HIS74-GLY82 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 1","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 196 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"7507481","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 72 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 2","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 72 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"7507481","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 100 |
| Details | Intramembrane: {"evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 72 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 3","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 76 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 4","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 5","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=Helix 6","evidences":[{"source":"PubMed","id":"35835865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8CT2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"11532455","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"11532455","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Site: {"description":"Hg(2+)-sensitive residue","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases","authoringGroup":["SeattleSNPs variation discovery resource"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q02013","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
