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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9Z4Q

Cryo-EM structure of human nonmuscle myosin-2B, Class 3

Functional Information from GO Data
ChainGOidnamespacecontents
A0000146molecular_functionmicrofilament motor activity
A0000281biological_processmitotic cytokinesis
A0001618molecular_functionvirus receptor activity
A0001725cellular_componentstress fiber
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005903cellular_componentbrush border
A0005938cellular_componentcell cortex
A0008360biological_processregulation of cell shape
A0009898cellular_componentcytoplasmic side of plasma membrane
A0009986cellular_componentcell surface
A0016459cellular_componentmyosin complex
A0016460cellular_componentmyosin II complex
A0030027cellular_componentlamellipodium
A0030048biological_processactin filament-based movement
A0030424cellular_componentaxon
A0030426cellular_componentgrowth cone
A0030496cellular_componentmidbody
A0031032biological_processactomyosin structure organization
A0031594cellular_componentneuromuscular junction
A0032154cellular_componentcleavage furrow
A0032982cellular_componentmyosin filament
A0035613molecular_functionRNA stem-loop binding
A0042641cellular_componentactomyosin
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0043531molecular_functionADP binding
A0045055biological_processregulated exocytosis
A0046718biological_processsymbiont entry into host cell
A0048027molecular_functionmRNA 5'-UTR binding
A0050714biological_processpositive regulation of protein secretion
A0051015molecular_functionactin filament binding
A0070062cellular_componentextracellular exosome
A0070382cellular_componentexocytic vesicle
A0097513cellular_componentmyosin II filament
A0098794cellular_componentpostsynapse
A0098871cellular_componentpostsynaptic actin cytoskeleton
A0098974biological_processpostsynaptic actin cytoskeleton organization
A0098978cellular_componentglutamatergic synapse
A0099500biological_processvesicle fusion to plasma membrane
B0000146molecular_functionmicrofilament motor activity
B0000281biological_processmitotic cytokinesis
B0001618molecular_functionvirus receptor activity
B0001725cellular_componentstress fiber
B0003779molecular_functionactin binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005903cellular_componentbrush border
B0005938cellular_componentcell cortex
B0008360biological_processregulation of cell shape
B0009898cellular_componentcytoplasmic side of plasma membrane
B0009986cellular_componentcell surface
B0016459cellular_componentmyosin complex
B0016460cellular_componentmyosin II complex
B0030027cellular_componentlamellipodium
B0030048biological_processactin filament-based movement
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0030496cellular_componentmidbody
B0031032biological_processactomyosin structure organization
B0031594cellular_componentneuromuscular junction
B0032154cellular_componentcleavage furrow
B0032982cellular_componentmyosin filament
B0035613molecular_functionRNA stem-loop binding
B0042641cellular_componentactomyosin
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043531molecular_functionADP binding
B0045055biological_processregulated exocytosis
B0046718biological_processsymbiont entry into host cell
B0048027molecular_functionmRNA 5'-UTR binding
B0050714biological_processpositive regulation of protein secretion
B0051015molecular_functionactin filament binding
B0070062cellular_componentextracellular exosome
B0070382cellular_componentexocytic vesicle
B0097513cellular_componentmyosin II filament
B0098794cellular_componentpostsynapse
B0098871cellular_componentpostsynaptic actin cytoskeleton
B0098974biological_processpostsynaptic actin cytoskeleton organization
B0098978cellular_componentglutamatergic synapse
B0099500biological_processvesicle fusion to plasma membrane
C0000146molecular_functionmicrofilament motor activity
C0003774molecular_functioncytoskeletal motor activity
C0005515molecular_functionprotein binding
C0005829cellular_componentcytosol
C0005903cellular_componentbrush border
C0006936biological_processmuscle contraction
C0007519biological_processskeletal muscle tissue development
C0008307molecular_functionstructural constituent of muscle
C0016020cellular_componentmembrane
C0016459cellular_componentmyosin complex
C0016460cellular_componentmyosin II complex
C0016461cellular_componentunconventional myosin complex
C0030049biological_processmuscle filament sliding
C0031982cellular_componentvesicle
C0070062cellular_componentextracellular exosome
D0001725cellular_componentstress fiber
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005903cellular_componentbrush border
D0005938cellular_componentcell cortex
D0016460cellular_componentmyosin II complex
D0030016cellular_componentmyofibril
D0030018cellular_componentZ disc
D0032036molecular_functionmyosin heavy chain binding
D0045177cellular_componentapical part of cell
D0070062cellular_componentextracellular exosome
E0001725cellular_componentstress fiber
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005903cellular_componentbrush border
E0005938cellular_componentcell cortex
E0016460cellular_componentmyosin II complex
E0030016cellular_componentmyofibril
E0030018cellular_componentZ disc
E0032036molecular_functionmyosin heavy chain binding
E0045177cellular_componentapical part of cell
E0070062cellular_componentextracellular exosome
F0000146molecular_functionmicrofilament motor activity
F0003774molecular_functioncytoskeletal motor activity
F0005515molecular_functionprotein binding
F0005829cellular_componentcytosol
F0005903cellular_componentbrush border
F0006936biological_processmuscle contraction
F0007519biological_processskeletal muscle tissue development
F0008307molecular_functionstructural constituent of muscle
F0016020cellular_componentmembrane
F0016459cellular_componentmyosin complex
F0016460cellular_componentmyosin II complex
F0016461cellular_componentunconventional myosin complex
F0030049biological_processmuscle filament sliding
F0031982cellular_componentvesicle
F0070062cellular_componentextracellular exosome
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DQNRDGFIDkeDL
ChainResidueDetails
DASP41-LEU53
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues58
DetailsDomain: {"description":"IQ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues44
DetailsRegion: {"description":"Actin-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00782","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues14
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues31
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues140
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues140
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues64
DetailsDomain: {"description":"EF-hand 3","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues70
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by MLCK and ZIPK/DAPK3","evidences":[{"source":"PubMed","id":"11942626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12429016","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15946647","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by MLCK and ZIPK/DAPK3","evidences":[{"source":"PubMed","id":"11942626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12429016","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15946647","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

258222

PDB entries from 2026-08-19

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