9Z26
Cryo-EM structure of human TRPM4 channel in complex with calcium and NBA at 37 degrees Celsius (monomeric TMD-focused map with best-resolved NBA density)
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 123 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B92","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B92","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
