9Z24
Cryo-EM structure of human TRPM4 channel in complex with calcium and CBA at 37 degrees Celsius (monomeric TMD-focused map with best-resolved CBA density)
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002407 | biological_process | dendritic cell chemotaxis |
| A | 0002724 | biological_process | regulation of T cell cytokine production |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0010460 | biological_process | positive regulation of heart rate |
| A | 0016020 | cellular_component | membrane |
| A | 0016925 | biological_process | protein sumoylation |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0030001 | biological_process | metal ion transport |
| A | 0030502 | biological_process | negative regulation of bone mineralization |
| A | 0034706 | cellular_component | sodium channel complex |
| A | 0035774 | biological_process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045600 | biological_process | positive regulation of fat cell differentiation |
| A | 0045668 | biological_process | negative regulation of osteoblast differentiation |
| A | 0045907 | biological_process | positive regulation of vasoconstriction |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071318 | biological_process | cellular response to ATP |
| A | 0086045 | biological_process | membrane depolarization during AV node cell action potential |
| A | 0086047 | biological_process | membrane depolarization during Purkinje myocyte cell action potential |
| A | 0086048 | biological_process | membrane depolarization during bundle of His cell action potential |
| A | 0086091 | biological_process | regulation of heart rate by cardiac conduction |
| A | 0090263 | biological_process | positive regulation of canonical Wnt signaling pathway |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0098719 | biological_process | sodium ion import across plasma membrane |
| A | 0098911 | biological_process | regulation of ventricular cardiac muscle cell action potential |
| A | 1903949 | biological_process | positive regulation of atrial cardiac muscle cell action potential |
| A | 1904179 | biological_process | positive regulation of adipose tissue development |
| A | 1904199 | biological_process | positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 123 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B92","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B92","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
