9Z05

Structure of human lymphoid-specific helicase HELLS in its auto-inhibitory state (D3)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000775	cellular_component	chromosome, centromeric region
A	0001822	biological_process	kidney development
A	0003682	molecular_function	chromatin binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005721	cellular_component	pericentric heterochromatin
A	0006302	biological_process	double-strand break repair
A	0006325	biological_process	chromatin organization
A	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
A	0016887	molecular_function	ATP hydrolysis activity
A	0031508	biological_process	pericentric heterochromatin formation
A	0035861	cellular_component	site of double-strand break
A	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
A	0046651	biological_process	lymphocyte proliferation
A	0140463	molecular_function	chromatin-protein adaptor activity
A	0140658	molecular_function	ATP-dependent chromatin remodeler activity
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000775	cellular_component	chromosome, centromeric region
B	0001822	biological_process	kidney development
B	0003682	molecular_function	chromatin binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005721	cellular_component	pericentric heterochromatin
B	0006302	biological_process	double-strand break repair
B	0006325	biological_process	chromatin organization
B	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
B	0016887	molecular_function	ATP hydrolysis activity
B	0031508	biological_process	pericentric heterochromatin formation
B	0035861	cellular_component	site of double-strand break
B	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
B	0046651	biological_process	lymphocyte proliferation
B	0140463	molecular_function	chromatin-protein adaptor activity
B	0140658	molecular_function	ATP-dependent chromatin remodeler activity
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0000775	cellular_component	chromosome, centromeric region
C	0001822	biological_process	kidney development
C	0003682	molecular_function	chromatin binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005721	cellular_component	pericentric heterochromatin
C	0006302	biological_process	double-strand break repair
C	0006325	biological_process	chromatin organization
C	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
C	0016887	molecular_function	ATP hydrolysis activity
C	0031508	biological_process	pericentric heterochromatin formation
C	0035861	cellular_component	site of double-strand break
C	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
C	0046651	biological_process	lymphocyte proliferation
C	0140463	molecular_function	chromatin-protein adaptor activity
C	0140658	molecular_function	ATP-dependent chromatin remodeler activity
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000775	cellular_component	chromosome, centromeric region
D	0001822	biological_process	kidney development
D	0003682	molecular_function	chromatin binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005721	cellular_component	pericentric heterochromatin
D	0006302	biological_process	double-strand break repair
D	0006325	biological_process	chromatin organization
D	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
D	0016887	molecular_function	ATP hydrolysis activity
D	0031508	biological_process	pericentric heterochromatin formation
D	0035861	cellular_component	site of double-strand break
D	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
D	0046651	biological_process	lymphocyte proliferation
D	0140463	molecular_function	chromatin-protein adaptor activity
D	0140658	molecular_function	ATP-dependent chromatin remodeler activity
E	0000724	biological_process	double-strand break repair via homologous recombination
E	0000775	cellular_component	chromosome, centromeric region
E	0001822	biological_process	kidney development
E	0003682	molecular_function	chromatin binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005721	cellular_component	pericentric heterochromatin
E	0006302	biological_process	double-strand break repair
E	0006325	biological_process	chromatin organization
E	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
E	0016887	molecular_function	ATP hydrolysis activity
E	0031508	biological_process	pericentric heterochromatin formation
E	0035861	cellular_component	site of double-strand break
E	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
E	0046651	biological_process	lymphocyte proliferation
E	0140463	molecular_function	chromatin-protein adaptor activity
E	0140658	molecular_function	ATP-dependent chromatin remodeler activity
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0000775	cellular_component	chromosome, centromeric region
F	0001822	biological_process	kidney development
F	0003682	molecular_function	chromatin binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0005721	cellular_component	pericentric heterochromatin
F	0006302	biological_process	double-strand break repair
F	0006325	biological_process	chromatin organization
F	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
F	0016887	molecular_function	ATP hydrolysis activity
F	0031508	biological_process	pericentric heterochromatin formation
F	0035861	cellular_component	site of double-strand break
F	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
F	0046651	biological_process	lymphocyte proliferation
F	0140463	molecular_function	chromatin-protein adaptor activity
F	0140658	molecular_function	ATP-dependent chromatin remodeler activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1008
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Motif: {"description":"DEAH box","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---