9YVO
Cryo-EM structure of the mouse TRPM4 channel bound to NC1 and PI(4,5)P2.
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 492 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29211714","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 88 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29211714","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 76 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29211714","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Region: {"description":"Mediates modulation by decavanadate and PIP2-binding","evidences":[{"source":"UniProtKB","id":"Q8TD43","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29211714","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BCO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BCQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8TD43","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"29211714","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BCO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BCQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"Q8TD43","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
