9YR7
Cryo-EM structure of human beta-cardiac myosin bound to mavacamten in the interacting-heads motif and S2-FH undocked state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0008218 | biological_process | bioluminescence |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0008218 | biological_process | bioluminescence |
| C | 0000146 | molecular_function | microfilament motor activity |
| C | 0003774 | molecular_function | cytoskeletal motor activity |
| C | 0006936 | biological_process | muscle contraction |
| C | 0008307 | molecular_function | structural constituent of muscle |
| C | 0016460 | cellular_component | myosin II complex |
| C | 0016461 | cellular_component | unconventional myosin complex |
| C | 0030016 | cellular_component | myofibril |
| C | 0030049 | biological_process | muscle filament sliding |
| C | 0043292 | cellular_component | contractile muscle fiber |
| C | 0060048 | biological_process | cardiac muscle contraction |
| D | 0000146 | molecular_function | microfilament motor activity |
| D | 0003774 | molecular_function | cytoskeletal motor activity |
| D | 0006936 | biological_process | muscle contraction |
| D | 0008307 | molecular_function | structural constituent of muscle |
| D | 0016460 | cellular_component | myosin II complex |
| D | 0016461 | cellular_component | unconventional myosin complex |
| D | 0030016 | cellular_component | myofibril |
| D | 0030049 | biological_process | muscle filament sliding |
| D | 0043292 | cellular_component | contractile muscle fiber |
| D | 0060048 | biological_process | cardiac muscle contraction |
| E | 0005509 | molecular_function | calcium ion binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006936 | biological_process | muscle contraction |
| E | 0007519 | biological_process | skeletal muscle tissue development |
| E | 0008307 | molecular_function | structural constituent of muscle |
| F | 0005509 | molecular_function | calcium ion binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006936 | biological_process | muscle contraction |
| F | 0007519 | biological_process | skeletal muscle tissue development |
| F | 0008307 | molecular_function | structural constituent of muscle |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DQNRDGIIDkeDL |
| Chain | Residue | Details |
| E | ASP38-LEU50 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 98 |
| Details | Domain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 693 |
| Details | Domain: {"description":"Myosin motor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00782","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 58 |
| Details | Domain: {"description":"IQ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 72 |
| Details | Region: {"description":"Actin-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02563","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 140 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 140 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02600","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02600","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P04466","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P04466","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
