9YR4
Cryo-EM structure of human Tom70 in complex with Hsp90 C-terminal EEVD peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0002230 | biological_process | positive regulation of defense response to virus by host |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005742 | cellular_component | mitochondrial outer membrane translocase complex |
| A | 0008320 | molecular_function | transmembrane protein transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0030150 | biological_process | protein import into mitochondrial matrix |
| A | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0032728 | biological_process | positive regulation of interferon-beta production |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0045039 | biological_process | protein insertion into mitochondrial inner membrane |
| A | 0045040 | biological_process | protein insertion into mitochondrial outer membrane |
| A | 0061052 | biological_process | negative regulation of cell growth involved in cardiac muscle cell development |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070585 | biological_process | protein localization to mitochondrion |
| A | 0097068 | biological_process | response to thyroxine |
| A | 0098586 | biological_process | cellular response to virus |
| A | 0140436 | molecular_function | mitochondrial signal sequence receptor activity |
| A | 0140596 | cellular_component | TOM complex |
| A | 1903749 | biological_process | positive regulation of protein localization to mitochondrion |
| A | 7770059 | biological_process | alpha helical protein insertion into mitochondrial outer membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"TPR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | Region: {"description":"Essential for interaction with SGTA and TTC1","evidences":[{"source":"PubMed","id":"15708368","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
