9YC5

Human uPAR bound to the Fab fragment of targeted cancer therapeutic antibody FL1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006935	biological_process	chemotaxis
A	0007160	biological_process	cell-matrix adhesion
A	0007165	biological_process	signal transduction
A	0007596	biological_process	blood coagulation
A	0008047	molecular_function	enzyme activator activity
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0010755	biological_process	regulation of plasminogen activation
A	0016020	cellular_component	membrane
A	0019898	cellular_component	extrinsic component of membrane
A	0019899	molecular_function	enzyme binding
A	0019904	molecular_function	protein domain specific binding
A	0030155	biological_process	regulation of cell adhesion
A	0030162	biological_process	regulation of proteolysis
A	0030377	molecular_function	urokinase plasminogen activator receptor activity
A	0031639	biological_process	plasminogen activation
A	0034112	biological_process	positive regulation of homotypic cell-cell adhesion
A	0034394	biological_process	protein localization to cell surface
A	0035579	cellular_component	specific granule membrane
A	0038023	molecular_function	signaling receptor activity
A	0038195	biological_process	urokinase plasminogen activator signaling pathway
A	0043066	biological_process	negative regulation of apoptotic process
A	0043388	biological_process	positive regulation of DNA binding
A	0045742	biological_process	positive regulation of epidermal growth factor receptor signaling pathway
A	0051917	biological_process	regulation of fibrinolysis
A	0090091	biological_process	positive regulation of extracellular matrix disassembly
A	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
A	0098634	molecular_function	cell-matrix adhesion mediator activity
A	2000117	biological_process	obsolete negative regulation of cysteine-type endopeptidase activity
A	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR197-HIS203

---

site_id	PS00983
Number of Residues	44
Details	LY6_UPAR Ly-6 / u-PAR domain signature. RCMqCktngd...Crve.....ECAlgqdlCrttivrlweegeelelveks....C

Chain	Residue	Details
A	ARG2-CYS45
A	GLU94-CYS147
A	GLN193-CYS247

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15861141","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15861141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16456079","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22285761","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---