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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9YAQ

The structure of the cardiac native cross bridge in the rigor state, myosin heads bound to actin molecules 5 and 6.

Functional Information from GO Data
ChainGOidnamespacecontents
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0007015biological_processactin filament organization
A0010628biological_processpositive regulation of gene expression
A0015629cellular_componentactin cytoskeleton
A0017022molecular_functionmyosin binding
A0030017cellular_componentsarcomere
A0030027cellular_componentlamellipodium
A0030175cellular_componentfilopodium
A0033275biological_processactin-myosin filament sliding
A0044297cellular_componentcell body
A0060047biological_processheart contraction
A0090131biological_processmesenchyme migration
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0007015biological_processactin filament organization
B0010628biological_processpositive regulation of gene expression
B0015629cellular_componentactin cytoskeleton
B0017022molecular_functionmyosin binding
B0030017cellular_componentsarcomere
B0030027cellular_componentlamellipodium
B0030175cellular_componentfilopodium
B0033275biological_processactin-myosin filament sliding
B0044297cellular_componentcell body
B0060047biological_processheart contraction
B0090131biological_processmesenchyme migration
C0005200molecular_functionstructural constituent of cytoskeleton
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0007015biological_processactin filament organization
C0010628biological_processpositive regulation of gene expression
C0015629cellular_componentactin cytoskeleton
C0017022molecular_functionmyosin binding
C0030017cellular_componentsarcomere
C0030027cellular_componentlamellipodium
C0030175cellular_componentfilopodium
C0033275biological_processactin-myosin filament sliding
C0044297cellular_componentcell body
C0060047biological_processheart contraction
C0090131biological_processmesenchyme migration
D0005200molecular_functionstructural constituent of cytoskeleton
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005856cellular_componentcytoskeleton
D0005884cellular_componentactin filament
D0007015biological_processactin filament organization
D0010628biological_processpositive regulation of gene expression
D0015629cellular_componentactin cytoskeleton
D0017022molecular_functionmyosin binding
D0030017cellular_componentsarcomere
D0030027cellular_componentlamellipodium
D0030175cellular_componentfilopodium
D0033275biological_processactin-myosin filament sliding
D0044297cellular_componentcell body
D0060047biological_processheart contraction
D0090131biological_processmesenchyme migration
E0005856cellular_componentcytoskeleton
E0005884cellular_componentactin filament
E0007015biological_processactin filament organization
E0015629cellular_componentactin cytoskeleton
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0046982molecular_functionprotein heterodimerization activity
E0051015molecular_functionactin filament binding
E0060048biological_processcardiac muscle contraction
F0005856cellular_componentcytoskeleton
F0005884cellular_componentactin filament
F0007015biological_processactin filament organization
F0015629cellular_componentactin cytoskeleton
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0046982molecular_functionprotein heterodimerization activity
F0051015molecular_functionactin filament binding
F0060048biological_processcardiac muscle contraction
G0005856cellular_componentcytoskeleton
G0005884cellular_componentactin filament
G0007015biological_processactin filament organization
G0015629cellular_componentactin cytoskeleton
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0046982molecular_functionprotein heterodimerization activity
G0051015molecular_functionactin filament binding
G0060048biological_processcardiac muscle contraction
H0005856cellular_componentcytoskeleton
H0005884cellular_componentactin filament
H0007015biological_processactin filament organization
H0015629cellular_componentactin cytoskeleton
H0042802molecular_functionidentical protein binding
H0042803molecular_functionprotein homodimerization activity
H0046982molecular_functionprotein heterodimerization activity
H0051015molecular_functionactin filament binding
H0060048biological_processcardiac muscle contraction
J0000146molecular_functionmicrofilament motor activity
J0005737cellular_componentcytoplasm
J0007512biological_processadult heart development
J0016460cellular_componentmyosin II complex
J0030016cellular_componentmyofibril
J0030017cellular_componentsarcomere
J0030049biological_processmuscle filament sliding
J0032982cellular_componentmyosin filament
J0051015molecular_functionactin filament binding
J0060048biological_processcardiac muscle contraction
K0000146molecular_functionmicrofilament motor activity
K0005737cellular_componentcytoplasm
K0007512biological_processadult heart development
K0016460cellular_componentmyosin II complex
K0030016cellular_componentmyofibril
K0030017cellular_componentsarcomere
K0030049biological_processmuscle filament sliding
K0032982cellular_componentmyosin filament
K0051015molecular_functionactin filament binding
K0060048biological_processcardiac muscle contraction
L0002026biological_processregulation of the force of heart contraction
L0003774molecular_functioncytoskeletal motor activity
L0003785molecular_functionactin monomer binding
L0006942biological_processregulation of striated muscle contraction
L0016460cellular_componentmyosin II complex
L0031672cellular_componentA band
L0031674cellular_componentI band
L0055010biological_processventricular cardiac muscle tissue morphogenesis
L0060048biological_processcardiac muscle contraction
M0002026biological_processregulation of the force of heart contraction
M0003774molecular_functioncytoskeletal motor activity
M0003785molecular_functionactin monomer binding
M0006942biological_processregulation of striated muscle contraction
M0016460cellular_componentmyosin II complex
M0031672cellular_componentA band
M0031674cellular_componentI band
M0055010biological_processventricular cardiac muscle tissue morphogenesis
M0060048biological_processcardiac muscle contraction
N0003009biological_processskeletal muscle contraction
N0005509molecular_functioncalcium ion binding
N0005861cellular_componenttroponin complex
N0006937biological_processregulation of muscle contraction
N0008092molecular_functioncytoskeletal protein binding
N0031013molecular_functiontroponin I binding
N0031014molecular_functiontroponin T binding
N0032972biological_processregulation of muscle filament sliding speed
N0042803molecular_functionprotein homodimerization activity
N0048306molecular_functioncalcium-dependent protein binding
N0051015molecular_functionactin filament binding
N0055010biological_processventricular cardiac muscle tissue morphogenesis
N0060048biological_processcardiac muscle contraction
N0086003biological_processcardiac muscle cell contraction
N1990584cellular_componentcardiac Troponin complex
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DEDGSGTVDfdEF
ChainResidueDetails
NASP65-PHE77
NASP105-LEU117
NASP141-PHE153
site_idPS00326
Number of Residues9
DetailsTROPOMYOSIN Tropomyosins signature. LKEAEtRAE
ChainResidueDetails
ELEU232-GLU240
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
ATYR53-GLY63
site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WISKqEYDE
ChainResidueDetails
ATRP356-GLU364
site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
ALEU104-ARG116
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P09493","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P58771","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P04692","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by DAPK1","evidences":[{"source":"UniProtKB","id":"P09493","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P09493","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues98
DetailsDomain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues72
DetailsRegion: {"description":"Actin-binding"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues14
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02563","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues693
DetailsDomain: {"description":"Myosin motor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00782","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues35
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues35
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues35
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues33
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues15
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P19123","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

258009

PDB entries from 2026-08-12

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