9YA9

Cryo-EM structure of ternary complex BCL6-CRBN-DDB1 with BMS-986458 (local refined), a potent and selective BCL6 ligand directed degrader (LDD)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0016020	cellular_component	membrane
C	0016567	biological_process	protein ubiquitination
C	0030177	biological_process	positive regulation of Wnt signaling pathway
C	0031333	biological_process	negative regulation of protein-containing complex assembly
C	0031334	biological_process	positive regulation of protein-containing complex assembly
C	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
C	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
C	0035641	biological_process	locomotory exploration behavior
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0044325	molecular_function	transmembrane transporter binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0060173	biological_process	limb development

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	134
Details	Domain: {"description":"BTB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00037","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	108
Details	Domain: {"description":"CULT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25108355","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TZ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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