9Y7M
HCMV Protease in complex with Fab5 - Class 2
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| B | TYR202-HIS208 | |
| C | TYR197-HIS203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"HAMAP-Rule","id":"MF_04008","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8805706","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"HAMAP-Rule","id":"MF_04008","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 238 |
| Chain | Residue | Details |
| B | PHE70 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | THR139 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | GLY141 | hydrogen bond donor, increase acidity, increase basicity |
| B | SER164 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity |
| B | HIS172 | electrostatic stabiliser, hydrogen bond donor |
| B | THR173 | electrostatic stabiliser, hydrogen bond donor |
