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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9Y3U

Eukaryotic translation initiation factor 2-B (eIF2B) with a truncation in the beta subunit (inactive state)

Functional Information from GO Data
ChainGOidnamespacecontents
E0001541biological_processovarian follicle development
E0002183biological_processcytoplasmic translational initiation
E0003743molecular_functiontranslation initiation factor activity
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005851cellular_componenteukaryotic translation initiation factor 2B complex
E0006413biological_processtranslational initiation
E0006417biological_processregulation of translation
E0007417biological_processcentral nervous system development
E0009408biological_processresponse to heat
E0009749biological_processresponse to glucose
E0014003biological_processoligodendrocyte development
E0031369molecular_functiontranslation initiation factor binding
E0042552biological_processmyelination
E0043434biological_processresponse to peptide hormone
E0045948biological_processpositive regulation of translational initiation
E0048513biological_processanimal organ development
E0050852biological_processT cell receptor signaling pathway
F0001541biological_processovarian follicle development
F0002183biological_processcytoplasmic translational initiation
F0003743molecular_functiontranslation initiation factor activity
F0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005851cellular_componenteukaryotic translation initiation factor 2B complex
F0006413biological_processtranslational initiation
F0006417biological_processregulation of translation
F0007417biological_processcentral nervous system development
F0009408biological_processresponse to heat
F0009749biological_processresponse to glucose
F0014003biological_processoligodendrocyte development
F0031369molecular_functiontranslation initiation factor binding
F0042552biological_processmyelination
F0043434biological_processresponse to peptide hormone
F0045948biological_processpositive regulation of translational initiation
F0048513biological_processanimal organ development
F0050852biological_processT cell receptor signaling pathway
G0002183biological_processcytoplasmic translational initiation
G0003743molecular_functiontranslation initiation factor activity
G0005085molecular_functionguanyl-nucleotide exchange factor activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005851cellular_componenteukaryotic translation initiation factor 2B complex
G0005886cellular_componentplasma membrane
G0006413biological_processtranslational initiation
G0009408biological_processresponse to heat
G0009749biological_processresponse to glucose
G0014003biological_processoligodendrocyte development
G0016020cellular_componentmembrane
G0042802molecular_functionidentical protein binding
G0043434biological_processresponse to peptide hormone
G0045948biological_processpositive regulation of translational initiation
G0050852biological_processT cell receptor signaling pathway
H0002183biological_processcytoplasmic translational initiation
H0003743molecular_functiontranslation initiation factor activity
H0005085molecular_functionguanyl-nucleotide exchange factor activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005851cellular_componenteukaryotic translation initiation factor 2B complex
H0005886cellular_componentplasma membrane
H0006413biological_processtranslational initiation
H0009408biological_processresponse to heat
H0009749biological_processresponse to glucose
H0014003biological_processoligodendrocyte development
H0016020cellular_componentmembrane
H0042802molecular_functionidentical protein binding
H0043434biological_processresponse to peptide hormone
H0045948biological_processpositive regulation of translational initiation
H0050852biological_processT cell receptor signaling pathway
I0002183biological_processcytoplasmic translational initiation
I0003743molecular_functiontranslation initiation factor activity
I0005085molecular_functionguanyl-nucleotide exchange factor activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005851cellular_componenteukaryotic translation initiation factor 2B complex
I0006412biological_processtranslation
I0006413biological_processtranslational initiation
I0007417biological_processcentral nervous system development
I0008135molecular_functiontranslation factor activity, RNA binding
I0009408biological_processresponse to heat
I0009749biological_processresponse to glucose
I0014003biological_processoligodendrocyte development
I0043434biological_processresponse to peptide hormone
I0045948biological_processpositive regulation of translational initiation
I0050852biological_processT cell receptor signaling pathway
J0002183biological_processcytoplasmic translational initiation
J0003743molecular_functiontranslation initiation factor activity
J0005085molecular_functionguanyl-nucleotide exchange factor activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005851cellular_componenteukaryotic translation initiation factor 2B complex
J0006412biological_processtranslation
J0006413biological_processtranslational initiation
J0007417biological_processcentral nervous system development
J0008135molecular_functiontranslation factor activity, RNA binding
J0009408biological_processresponse to heat
J0009749biological_processresponse to glucose
J0014003biological_processoligodendrocyte development
J0043434biological_processresponse to peptide hormone
J0045948biological_processpositive regulation of translational initiation
J0050852biological_processT cell receptor signaling pathway
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues10
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues18
DetailsRegion: {"description":"May bind the chemical integrated stress response (ISR) inhibitor ISRIB","evidences":[{"source":"PubMed","id":"25858979","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

258009

PDB entries from 2026-08-12

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