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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9XHH

Structure of the CCL19-CCR7-Gi-scFv16 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
A0009898cellular_componentcytoplasmic side of plasma membrane
A0016020cellular_componentmembrane
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031681molecular_functionG-protein beta-subunit binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0045202cellular_componentsynapse
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A0071380biological_processcellular response to prostaglandin E stimulus
A0071870biological_processcellular response to catecholamine stimulus
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0051020molecular_functionGTPase binding
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0000287molecular_functionmagnesium ion binding
C0001664molecular_functionG protein-coupled receptor binding
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0005938cellular_componentcell cortex
C0007186biological_processG protein-coupled receptor signaling pathway
C0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0009898cellular_componentcytoplasmic side of plasma membrane
C0016020cellular_componentmembrane
C0019003molecular_functionGDP binding
C0030496cellular_componentmidbody
C0031681molecular_functionG-protein beta-subunit binding
C0031683molecular_functionG-protein beta/gamma-subunit complex binding
C0031821molecular_functionG protein-coupled serotonin receptor binding
C0045202cellular_componentsynapse
C0051301biological_processcell division
C0060236biological_processregulation of mitotic spindle organization
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C1904322biological_processcellular response to forskolin
C1904778biological_processpositive regulation of protein localization to cell cortex
L0001768biological_processestablishment of T cell polarity
L0001771biological_processimmunological synapse formation
L0002407biological_processdendritic cell chemotaxis
L0002408biological_processmyeloid dendritic cell chemotaxis
L0002606biological_processpositive regulation of dendritic cell antigen processing and presentation
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0006874biological_processintracellular calcium ion homeostasis
L0006954biological_processinflammatory response
L0006955biological_processimmune response
L0007154biological_processcell communication
L0008009molecular_functionchemokine activity
L0009615biological_processresponse to virus
L0010560biological_processpositive regulation of glycoprotein biosynthetic process
L0030335biological_processpositive regulation of cell migration
L0031295biological_processT cell costimulation
L0031732molecular_functionCCR7 chemokine receptor binding
L0031735molecular_functionCCR10 chemokine receptor binding
L0032489biological_processregulation of Cdc42 protein signal transduction
L0032731biological_processpositive regulation of interleukin-1 beta production
L0032735biological_processpositive regulation of interleukin-12 production
L0032760biological_processpositive regulation of tumor necrosis factor production
L0035022biological_processpositive regulation of Rac protein signal transduction
L0038119biological_processCCL19-activated CCR7 signaling pathway
L0042102biological_processpositive regulation of T cell proliferation
L0042379molecular_functionchemokine receptor binding
L0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
L0045627biological_processpositive regulation of T-helper 1 cell differentiation
L0045807biological_processpositive regulation of endocytosis
L0046330biological_processpositive regulation of JNK cascade
L0048020molecular_functionCCR chemokine receptor binding
L0048245biological_processeosinophil chemotaxis
L0048260biological_processpositive regulation of receptor-mediated endocytosis
L0048469biological_processcell maturation
L0050921biological_processpositive regulation of chemotaxis
L0051209biological_processrelease of sequestered calcium ion into cytosol
L0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
L0060491biological_processregulation of cell projection assembly
L0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
L0070098biological_processchemokine-mediated signaling pathway
L0070374biological_processpositive regulation of ERK1 and ERK2 cascade
L0071380biological_processcellular response to prostaglandin E stimulus
L0071731biological_processresponse to nitric oxide
L0090023biological_processpositive regulation of neutrophil chemotaxis
L0097029biological_processmature conventional dendritic cell differentiation
L0098586biological_processcellular response to virus
L0141214biological_processpositive regulation of phospholipase C/protein kinase C signal transduction
L1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
L2000147biological_processpositive regulation of cell motility
L2000549biological_processpositive regulation of dendritic cell dendrite assembly
L2000669biological_processnegative regulation of dendritic cell apoptotic process
R0001768biological_processestablishment of T cell polarity
R0001954biological_processpositive regulation of cell-matrix adhesion
R0002407biological_processdendritic cell chemotaxis
R0002408biological_processmyeloid dendritic cell chemotaxis
R0002606biological_processpositive regulation of dendritic cell antigen processing and presentation
R0002885biological_processpositive regulation of hypersensitivity
R0002922biological_processpositive regulation of humoral immune response
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005739cellular_componentmitochondrion
R0005886cellular_componentplasma membrane
R0006954biological_processinflammatory response
R0006955biological_processimmune response
R0007186biological_processG protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0009897cellular_componentexternal side of plasma membrane
R0009986cellular_componentcell surface
R0016493molecular_functionC-C chemokine receptor activity
R0019722biological_processcalcium-mediated signaling
R0030838biological_processpositive regulation of actin filament polymerization
R0031274biological_processpositive regulation of pseudopodium assembly
R0031529biological_processruffle organization
R0032489biological_processregulation of Cdc42 protein signal transduction
R0032496biological_processresponse to lipopolysaccharide
R0032649biological_processregulation of type II interferon production
R0032651biological_processregulation of interleukin-1 beta production
R0032695biological_processnegative regulation of interleukin-12 production
R0032735biological_processpositive regulation of interleukin-12 production
R0035022biological_processpositive regulation of Rac protein signal transduction
R0035757molecular_functionchemokine (C-C motif) ligand 19 binding
R0035758molecular_functionchemokine (C-C motif) ligand 21 binding
R0038117molecular_functionC-C motif chemokine 19 receptor activity
R0038119biological_processCCL19-activated CCR7 signaling pathway
R0038120biological_processCCL21-activated CCR7 signaling pathway
R0038121molecular_functionC-C motif chemokine 21 receptor activity
R0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
R0045060biological_processnegative thymic T cell selection
R0045785biological_processpositive regulation of cell adhesion
R0046330biological_processpositive regulation of JNK cascade
R0048260biological_processpositive regulation of receptor-mediated endocytosis
R0050862biological_processpositive regulation of T cell receptor signaling pathway
R0051209biological_processrelease of sequestered calcium ion into cytosol
R0051491biological_processpositive regulation of filopodium assembly
R0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
R0060326biological_processcell chemotaxis
R0070374biological_processpositive regulation of ERK1 and ERK2 cascade
R0071345biological_processcellular response to cytokine stimulus
R0071380biological_processcellular response to prostaglandin E stimulus
R0071731biological_processresponse to nitric oxide
R0090023biological_processpositive regulation of neutrophil chemotaxis
R0097022biological_processlymphocyte migration into lymph node
R0097029biological_processmature conventional dendritic cell differentiation
R0141214biological_processpositive regulation of phospholipase C/protein kinase C signal transduction
R2000147biological_processpositive regulation of cell motility
R2000510biological_processpositive regulation of dendritic cell chemotaxis
R2000522biological_processpositive regulation of immunological synapse formation
R2000525biological_processpositive regulation of T cell costimulation
R2000547biological_processregulation of dendritic cell dendrite assembly
R2000669biological_processnegative regulation of dendritic cell apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGMlLLLCISIDRYVaI
ChainResidueDetails
RSER142-ILE158
site_idPS00472
Number of Residues44
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLsvtqkp..IpgyiVrnFhyllikdgCrvp.AVVFttlrgrql.CA
ChainResidueDetails
LCYS8-ALA51
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU69-SER83
BILE156-ILE170
BLEU284-ALA298
BVAL326-GLY340
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues40
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues63
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues27
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues48
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues45
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues40
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues41
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues43
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues41
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues30
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues13
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues9
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues7
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues5
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P10824","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsLipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"UniProtKB","id":"P63096","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues1
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P10824","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

254917

PDB entries from 2026-06-10

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