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9WZB

K21E/K22E-ASC CARD filament

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001773biological_processmyeloid dendritic cell activation
A0002020molecular_functionprotease binding
A0002218biological_processactivation of innate immune response
A0002221biological_processpattern recognition receptor signaling pathway
A0002230biological_processpositive regulation of defense response to virus by host
A0002277biological_processmyeloid dendritic cell activation involved in immune response
A0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
A0002821biological_processpositive regulation of adaptive immune response
A0005138molecular_functioninterleukin-6 receptor binding
A0005515molecular_functionprotein binding
A0005523molecular_functiontropomyosin binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0007165biological_processsignal transduction
A0007231biological_processosmosensory signaling pathway
A0008385cellular_componentIkappaB kinase complex
A0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
A0017024molecular_functionmyosin I binding
A0019899molecular_functionenzyme binding
A0030674molecular_functionprotein-macromolecule adaptor activity
A0030838biological_processpositive regulation of actin filament polymerization
A0031647biological_processregulation of protein stability
A0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
A0032090molecular_functionPyrin domain binding
A0032688biological_processnegative regulation of interferon-beta production
A0032722biological_processpositive regulation of chemokine production
A0032729biological_processpositive regulation of type II interferon production
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032733biological_processpositive regulation of interleukin-10 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032757biological_processpositive regulation of interleukin-8 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032991cellular_componentprotein-containing complex
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0034774cellular_componentsecretory granule lumen
A0035578cellular_componentazurophil granule lumen
A0038187molecular_functionpattern recognition receptor activity
A0042104biological_processpositive regulation of activated T cell proliferation
A0042742biological_processdefense response to bacterium
A0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042981biological_processregulation of apoptotic process
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0044325molecular_functiontransmembrane transporter binding
A0044351biological_processmacropinocytosis
A0044546biological_processNLRP3 inflammasome complex assembly
A0046330biological_processpositive regulation of JNK cascade
A0046456biological_processicosanoid biosynthetic process
A0046983molecular_functionprotein dimerization activity
A0050727biological_processregulation of inflammatory response
A0050729biological_processpositive regulation of inflammatory response
A0050766biological_processpositive regulation of phagocytosis
A0050829biological_processdefense response to Gram-negative bacterium
A0050870biological_processpositive regulation of T cell activation
A0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
A0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
A0051260biological_processprotein homooligomerization
A0051607biological_processdefense response to virus
A0061702cellular_componentcanonical inflammasome complex
A0070269biological_processpyroptotic inflammatory response
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070700molecular_functionBMP receptor binding
A0071222biological_processcellular response to lipopolysaccharide
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0071901biological_processnegative regulation of protein serine/threonine kinase activity
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
A0072558cellular_componentNLRP1 inflammasome complex
A0072559cellular_componentNLRP3 inflammasome complex
A0090200biological_processpositive regulation of release of cytochrome c from mitochondria
A0097169cellular_componentAIM2 inflammasome complex
A0097190biological_processapoptotic signaling pathway
A0097193biological_processintrinsic apoptotic signaling pathway
A0140608molecular_functioncysteine-type endopeptidase activator activity
A0140632biological_processcanonical inflammasome complex assembly
A0140738cellular_componentNLRP6 inflammasome complex
A1900016biological_processnegative regulation of cytokine production involved in inflammatory response
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A2000406biological_processpositive regulation of T cell migration
A2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
A2001242biological_processregulation of intrinsic apoptotic signaling pathway
B0000139cellular_componentGolgi membrane
B0001773biological_processmyeloid dendritic cell activation
B0002020molecular_functionprotease binding
B0002218biological_processactivation of innate immune response
B0002221biological_processpattern recognition receptor signaling pathway
B0002230biological_processpositive regulation of defense response to virus by host
B0002277biological_processmyeloid dendritic cell activation involved in immune response
B0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
B0002821biological_processpositive regulation of adaptive immune response
B0005138molecular_functioninterleukin-6 receptor binding
B0005515molecular_functionprotein binding
B0005523molecular_functiontropomyosin binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005874cellular_componentmicrotubule
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0007165biological_processsignal transduction
B0007231biological_processosmosensory signaling pathway
B0008385cellular_componentIkappaB kinase complex
B0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
B0017024molecular_functionmyosin I binding
B0019899molecular_functionenzyme binding
B0030674molecular_functionprotein-macromolecule adaptor activity
B0030838biological_processpositive regulation of actin filament polymerization
B0031647biological_processregulation of protein stability
B0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
B0032090molecular_functionPyrin domain binding
B0032688biological_processnegative regulation of interferon-beta production
B0032722biological_processpositive regulation of chemokine production
B0032729biological_processpositive regulation of type II interferon production
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032733biological_processpositive regulation of interleukin-10 production
B0032755biological_processpositive regulation of interleukin-6 production
B0032757biological_processpositive regulation of interleukin-8 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0032991cellular_componentprotein-containing complex
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0034774cellular_componentsecretory granule lumen
B0035578cellular_componentazurophil granule lumen
B0038187molecular_functionpattern recognition receptor activity
B0042104biological_processpositive regulation of activated T cell proliferation
B0042742biological_processdefense response to bacterium
B0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042981biological_processregulation of apoptotic process
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0044325molecular_functiontransmembrane transporter binding
B0044351biological_processmacropinocytosis
B0044546biological_processNLRP3 inflammasome complex assembly
B0046330biological_processpositive regulation of JNK cascade
B0046456biological_processicosanoid biosynthetic process
B0046983molecular_functionprotein dimerization activity
B0050727biological_processregulation of inflammatory response
B0050729biological_processpositive regulation of inflammatory response
B0050766biological_processpositive regulation of phagocytosis
B0050829biological_processdefense response to Gram-negative bacterium
B0050870biological_processpositive regulation of T cell activation
B0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
B0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
B0051260biological_processprotein homooligomerization
B0051607biological_processdefense response to virus
B0061702cellular_componentcanonical inflammasome complex
B0070269biological_processpyroptotic inflammatory response
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070700molecular_functionBMP receptor binding
B0071222biological_processcellular response to lipopolysaccharide
B0071347biological_processcellular response to interleukin-1
B0071356biological_processcellular response to tumor necrosis factor
B0071901biological_processnegative regulation of protein serine/threonine kinase activity
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B0072558cellular_componentNLRP1 inflammasome complex
B0072559cellular_componentNLRP3 inflammasome complex
B0090200biological_processpositive regulation of release of cytochrome c from mitochondria
B0097169cellular_componentAIM2 inflammasome complex
B0097190biological_processapoptotic signaling pathway
B0097193biological_processintrinsic apoptotic signaling pathway
B0140608molecular_functioncysteine-type endopeptidase activator activity
B0140632biological_processcanonical inflammasome complex assembly
B0140738cellular_componentNLRP6 inflammasome complex
B1900016biological_processnegative regulation of cytokine production involved in inflammatory response
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B2000406biological_processpositive regulation of T cell migration
B2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
B2001242biological_processregulation of intrinsic apoptotic signaling pathway
C0000139cellular_componentGolgi membrane
C0001773biological_processmyeloid dendritic cell activation
C0002020molecular_functionprotease binding
C0002218biological_processactivation of innate immune response
C0002221biological_processpattern recognition receptor signaling pathway
C0002230biological_processpositive regulation of defense response to virus by host
C0002277biological_processmyeloid dendritic cell activation involved in immune response
C0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
C0002821biological_processpositive regulation of adaptive immune response
C0005138molecular_functioninterleukin-6 receptor binding
C0005515molecular_functionprotein binding
C0005523molecular_functiontropomyosin binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0005874cellular_componentmicrotubule
C0006915biological_processapoptotic process
C0006954biological_processinflammatory response
C0007165biological_processsignal transduction
C0007231biological_processosmosensory signaling pathway
C0008385cellular_componentIkappaB kinase complex
C0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
C0017024molecular_functionmyosin I binding
C0019899molecular_functionenzyme binding
C0030674molecular_functionprotein-macromolecule adaptor activity
C0030838biological_processpositive regulation of actin filament polymerization
C0031647biological_processregulation of protein stability
C0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
C0032090molecular_functionPyrin domain binding
C0032688biological_processnegative regulation of interferon-beta production
C0032722biological_processpositive regulation of chemokine production
C0032729biological_processpositive regulation of type II interferon production
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032733biological_processpositive regulation of interleukin-10 production
C0032755biological_processpositive regulation of interleukin-6 production
C0032757biological_processpositive regulation of interleukin-8 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0032991cellular_componentprotein-containing complex
C0033209biological_processtumor necrosis factor-mediated signaling pathway
C0034774cellular_componentsecretory granule lumen
C0035578cellular_componentazurophil granule lumen
C0038187molecular_functionpattern recognition receptor activity
C0042104biological_processpositive regulation of activated T cell proliferation
C0042742biological_processdefense response to bacterium
C0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0042981biological_processregulation of apoptotic process
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
C0044325molecular_functiontransmembrane transporter binding
C0044351biological_processmacropinocytosis
C0044546biological_processNLRP3 inflammasome complex assembly
C0046330biological_processpositive regulation of JNK cascade
C0046456biological_processicosanoid biosynthetic process
C0046983molecular_functionprotein dimerization activity
C0050727biological_processregulation of inflammatory response
C0050729biological_processpositive regulation of inflammatory response
C0050766biological_processpositive regulation of phagocytosis
C0050829biological_processdefense response to Gram-negative bacterium
C0050870biological_processpositive regulation of T cell activation
C0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
C0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
C0051260biological_processprotein homooligomerization
C0051607biological_processdefense response to virus
C0061702cellular_componentcanonical inflammasome complex
C0070269biological_processpyroptotic inflammatory response
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0070700molecular_functionBMP receptor binding
C0071222biological_processcellular response to lipopolysaccharide
C0071347biological_processcellular response to interleukin-1
C0071356biological_processcellular response to tumor necrosis factor
C0071901biological_processnegative regulation of protein serine/threonine kinase activity
C0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
C0072558cellular_componentNLRP1 inflammasome complex
C0072559cellular_componentNLRP3 inflammasome complex
C0090200biological_processpositive regulation of release of cytochrome c from mitochondria
C0097169cellular_componentAIM2 inflammasome complex
C0097190biological_processapoptotic signaling pathway
C0097193biological_processintrinsic apoptotic signaling pathway
C0140608molecular_functioncysteine-type endopeptidase activator activity
C0140632biological_processcanonical inflammasome complex assembly
C0140738cellular_componentNLRP6 inflammasome complex
C1900016biological_processnegative regulation of cytokine production involved in inflammatory response
C1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
C2000406biological_processpositive regulation of T cell migration
C2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
C2001242biological_processregulation of intrinsic apoptotic signaling pathway
D0000139cellular_componentGolgi membrane
D0001773biological_processmyeloid dendritic cell activation
D0002020molecular_functionprotease binding
D0002218biological_processactivation of innate immune response
D0002221biological_processpattern recognition receptor signaling pathway
D0002230biological_processpositive regulation of defense response to virus by host
D0002277biological_processmyeloid dendritic cell activation involved in immune response
D0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
D0002821biological_processpositive regulation of adaptive immune response
D0005138molecular_functioninterleukin-6 receptor binding
D0005515molecular_functionprotein binding
D0005523molecular_functiontropomyosin binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0005874cellular_componentmicrotubule
D0006915biological_processapoptotic process
D0006954biological_processinflammatory response
D0007165biological_processsignal transduction
D0007231biological_processosmosensory signaling pathway
D0008385cellular_componentIkappaB kinase complex
D0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
D0017024molecular_functionmyosin I binding
D0019899molecular_functionenzyme binding
D0030674molecular_functionprotein-macromolecule adaptor activity
D0030838biological_processpositive regulation of actin filament polymerization
D0031647biological_processregulation of protein stability
D0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
D0032090molecular_functionPyrin domain binding
D0032688biological_processnegative regulation of interferon-beta production
D0032722biological_processpositive regulation of chemokine production
D0032729biological_processpositive regulation of type II interferon production
D0032731biological_processpositive regulation of interleukin-1 beta production
D0032733biological_processpositive regulation of interleukin-10 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032757biological_processpositive regulation of interleukin-8 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032991cellular_componentprotein-containing complex
D0033209biological_processtumor necrosis factor-mediated signaling pathway
D0034774cellular_componentsecretory granule lumen
D0035578cellular_componentazurophil granule lumen
D0038187molecular_functionpattern recognition receptor activity
D0042104biological_processpositive regulation of activated T cell proliferation
D0042742biological_processdefense response to bacterium
D0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042981biological_processregulation of apoptotic process
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
D0044325molecular_functiontransmembrane transporter binding
D0044351biological_processmacropinocytosis
D0044546biological_processNLRP3 inflammasome complex assembly
D0046330biological_processpositive regulation of JNK cascade
D0046456biological_processicosanoid biosynthetic process
D0046983molecular_functionprotein dimerization activity
D0050727biological_processregulation of inflammatory response
D0050729biological_processpositive regulation of inflammatory response
D0050766biological_processpositive regulation of phagocytosis
D0050829biological_processdefense response to Gram-negative bacterium
D0050870biological_processpositive regulation of T cell activation
D0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
D0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
D0051260biological_processprotein homooligomerization
D0051607biological_processdefense response to virus
D0061702cellular_componentcanonical inflammasome complex
D0070269biological_processpyroptotic inflammatory response
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070700molecular_functionBMP receptor binding
D0071222biological_processcellular response to lipopolysaccharide
D0071347biological_processcellular response to interleukin-1
D0071356biological_processcellular response to tumor necrosis factor
D0071901biological_processnegative regulation of protein serine/threonine kinase activity
D0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
D0072558cellular_componentNLRP1 inflammasome complex
D0072559cellular_componentNLRP3 inflammasome complex
D0090200biological_processpositive regulation of release of cytochrome c from mitochondria
D0097169cellular_componentAIM2 inflammasome complex
D0097190biological_processapoptotic signaling pathway
D0097193biological_processintrinsic apoptotic signaling pathway
D0140608molecular_functioncysteine-type endopeptidase activator activity
D0140632biological_processcanonical inflammasome complex assembly
D0140738cellular_componentNLRP6 inflammasome complex
D1900016biological_processnegative regulation of cytokine production involved in inflammatory response
D1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
D2000406biological_processpositive regulation of T cell migration
D2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
D2001242biological_processregulation of intrinsic apoptotic signaling pathway
E0000139cellular_componentGolgi membrane
E0001773biological_processmyeloid dendritic cell activation
E0002020molecular_functionprotease binding
E0002218biological_processactivation of innate immune response
E0002221biological_processpattern recognition receptor signaling pathway
E0002230biological_processpositive regulation of defense response to virus by host
E0002277biological_processmyeloid dendritic cell activation involved in immune response
E0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
E0002821biological_processpositive regulation of adaptive immune response
E0005138molecular_functioninterleukin-6 receptor binding
E0005515molecular_functionprotein binding
E0005523molecular_functiontropomyosin binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005783cellular_componentendoplasmic reticulum
E0005829cellular_componentcytosol
E0005874cellular_componentmicrotubule
E0006915biological_processapoptotic process
E0006954biological_processinflammatory response
E0007165biological_processsignal transduction
E0007231biological_processosmosensory signaling pathway
E0008385cellular_componentIkappaB kinase complex
E0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
E0017024molecular_functionmyosin I binding
E0019899molecular_functionenzyme binding
E0030674molecular_functionprotein-macromolecule adaptor activity
E0030838biological_processpositive regulation of actin filament polymerization
E0031647biological_processregulation of protein stability
E0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
E0032090molecular_functionPyrin domain binding
E0032688biological_processnegative regulation of interferon-beta production
E0032722biological_processpositive regulation of chemokine production
E0032729biological_processpositive regulation of type II interferon production
E0032731biological_processpositive regulation of interleukin-1 beta production
E0032733biological_processpositive regulation of interleukin-10 production
E0032755biological_processpositive regulation of interleukin-6 production
E0032757biological_processpositive regulation of interleukin-8 production
E0032760biological_processpositive regulation of tumor necrosis factor production
E0032991cellular_componentprotein-containing complex
E0033209biological_processtumor necrosis factor-mediated signaling pathway
E0034774cellular_componentsecretory granule lumen
E0035578cellular_componentazurophil granule lumen
E0038187molecular_functionpattern recognition receptor activity
E0042104biological_processpositive regulation of activated T cell proliferation
E0042742biological_processdefense response to bacterium
E0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0042981biological_processregulation of apoptotic process
E0043025cellular_componentneuronal cell body
E0043065biological_processpositive regulation of apoptotic process
E0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
E0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
E0044325molecular_functiontransmembrane transporter binding
E0044351biological_processmacropinocytosis
E0044546biological_processNLRP3 inflammasome complex assembly
E0046330biological_processpositive regulation of JNK cascade
E0046456biological_processicosanoid biosynthetic process
E0046983molecular_functionprotein dimerization activity
E0050727biological_processregulation of inflammatory response
E0050729biological_processpositive regulation of inflammatory response
E0050766biological_processpositive regulation of phagocytosis
E0050829biological_processdefense response to Gram-negative bacterium
E0050870biological_processpositive regulation of T cell activation
E0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
E0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
E0051260biological_processprotein homooligomerization
E0051607biological_processdefense response to virus
E0061702cellular_componentcanonical inflammasome complex
E0070269biological_processpyroptotic inflammatory response
E0070374biological_processpositive regulation of ERK1 and ERK2 cascade
E0070700molecular_functionBMP receptor binding
E0071222biological_processcellular response to lipopolysaccharide
E0071347biological_processcellular response to interleukin-1
E0071356biological_processcellular response to tumor necrosis factor
E0071901biological_processnegative regulation of protein serine/threonine kinase activity
E0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
E0072558cellular_componentNLRP1 inflammasome complex
E0072559cellular_componentNLRP3 inflammasome complex
E0090200biological_processpositive regulation of release of cytochrome c from mitochondria
E0097169cellular_componentAIM2 inflammasome complex
E0097190biological_processapoptotic signaling pathway
E0097193biological_processintrinsic apoptotic signaling pathway
E0140608molecular_functioncysteine-type endopeptidase activator activity
E0140632biological_processcanonical inflammasome complex assembly
E0140738cellular_componentNLRP6 inflammasome complex
E1900016biological_processnegative regulation of cytokine production involved in inflammatory response
E1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
E2000406biological_processpositive regulation of T cell migration
E2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
E2001242biological_processregulation of intrinsic apoptotic signaling pathway
F0000139cellular_componentGolgi membrane
F0001773biological_processmyeloid dendritic cell activation
F0002020molecular_functionprotease binding
F0002218biological_processactivation of innate immune response
F0002221biological_processpattern recognition receptor signaling pathway
F0002230biological_processpositive regulation of defense response to virus by host
F0002277biological_processmyeloid dendritic cell activation involved in immune response
F0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
F0002821biological_processpositive regulation of adaptive immune response
F0005138molecular_functioninterleukin-6 receptor binding
F0005515molecular_functionprotein binding
F0005523molecular_functiontropomyosin binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005783cellular_componentendoplasmic reticulum
F0005829cellular_componentcytosol
F0005874cellular_componentmicrotubule
F0006915biological_processapoptotic process
F0006954biological_processinflammatory response
F0007165biological_processsignal transduction
F0007231biological_processosmosensory signaling pathway
F0008385cellular_componentIkappaB kinase complex
F0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
F0017024molecular_functionmyosin I binding
F0019899molecular_functionenzyme binding
F0030674molecular_functionprotein-macromolecule adaptor activity
F0030838biological_processpositive regulation of actin filament polymerization
F0031647biological_processregulation of protein stability
F0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
F0032090molecular_functionPyrin domain binding
F0032688biological_processnegative regulation of interferon-beta production
F0032722biological_processpositive regulation of chemokine production
F0032729biological_processpositive regulation of type II interferon production
F0032731biological_processpositive regulation of interleukin-1 beta production
F0032733biological_processpositive regulation of interleukin-10 production
F0032755biological_processpositive regulation of interleukin-6 production
F0032757biological_processpositive regulation of interleukin-8 production
F0032760biological_processpositive regulation of tumor necrosis factor production
F0032991cellular_componentprotein-containing complex
F0033209biological_processtumor necrosis factor-mediated signaling pathway
F0034774cellular_componentsecretory granule lumen
F0035578cellular_componentazurophil granule lumen
F0038187molecular_functionpattern recognition receptor activity
F0042104biological_processpositive regulation of activated T cell proliferation
F0042742biological_processdefense response to bacterium
F0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0042981biological_processregulation of apoptotic process
F0043025cellular_componentneuronal cell body
F0043065biological_processpositive regulation of apoptotic process
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
F0044325molecular_functiontransmembrane transporter binding
F0044351biological_processmacropinocytosis
F0044546biological_processNLRP3 inflammasome complex assembly
F0046330biological_processpositive regulation of JNK cascade
F0046456biological_processicosanoid biosynthetic process
F0046983molecular_functionprotein dimerization activity
F0050727biological_processregulation of inflammatory response
F0050729biological_processpositive regulation of inflammatory response
F0050766biological_processpositive regulation of phagocytosis
F0050829biological_processdefense response to Gram-negative bacterium
F0050870biological_processpositive regulation of T cell activation
F0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
F0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
F0051260biological_processprotein homooligomerization
F0051607biological_processdefense response to virus
F0061702cellular_componentcanonical inflammasome complex
F0070269biological_processpyroptotic inflammatory response
F0070374biological_processpositive regulation of ERK1 and ERK2 cascade
F0070700molecular_functionBMP receptor binding
F0071222biological_processcellular response to lipopolysaccharide
F0071347biological_processcellular response to interleukin-1
F0071356biological_processcellular response to tumor necrosis factor
F0071901biological_processnegative regulation of protein serine/threonine kinase activity
F0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
F0072558cellular_componentNLRP1 inflammasome complex
F0072559cellular_componentNLRP3 inflammasome complex
F0090200biological_processpositive regulation of release of cytochrome c from mitochondria
F0097169cellular_componentAIM2 inflammasome complex
F0097190biological_processapoptotic signaling pathway
F0097193biological_processintrinsic apoptotic signaling pathway
F0140608molecular_functioncysteine-type endopeptidase activator activity
F0140632biological_processcanonical inflammasome complex assembly
F0140738cellular_componentNLRP6 inflammasome complex
F1900016biological_processnegative regulation of cytokine production involved in inflammatory response
F1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
F2000406biological_processpositive regulation of T cell migration
F2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
F2001242biological_processregulation of intrinsic apoptotic signaling pathway
G0000139cellular_componentGolgi membrane
G0001773biological_processmyeloid dendritic cell activation
G0002020molecular_functionprotease binding
G0002218biological_processactivation of innate immune response
G0002221biological_processpattern recognition receptor signaling pathway
G0002230biological_processpositive regulation of defense response to virus by host
G0002277biological_processmyeloid dendritic cell activation involved in immune response
G0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
G0002821biological_processpositive regulation of adaptive immune response
G0005138molecular_functioninterleukin-6 receptor binding
G0005515molecular_functionprotein binding
G0005523molecular_functiontropomyosin binding
G0005576cellular_componentextracellular region
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005730cellular_componentnucleolus
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005783cellular_componentendoplasmic reticulum
G0005829cellular_componentcytosol
G0005874cellular_componentmicrotubule
G0006915biological_processapoptotic process
G0006954biological_processinflammatory response
G0007165biological_processsignal transduction
G0007231biological_processosmosensory signaling pathway
G0008385cellular_componentIkappaB kinase complex
G0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
G0017024molecular_functionmyosin I binding
G0019899molecular_functionenzyme binding
G0030674molecular_functionprotein-macromolecule adaptor activity
G0030838biological_processpositive regulation of actin filament polymerization
G0031647biological_processregulation of protein stability
G0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
G0032090molecular_functionPyrin domain binding
G0032688biological_processnegative regulation of interferon-beta production
G0032722biological_processpositive regulation of chemokine production
G0032729biological_processpositive regulation of type II interferon production
G0032731biological_processpositive regulation of interleukin-1 beta production
G0032733biological_processpositive regulation of interleukin-10 production
G0032755biological_processpositive regulation of interleukin-6 production
G0032757biological_processpositive regulation of interleukin-8 production
G0032760biological_processpositive regulation of tumor necrosis factor production
G0032991cellular_componentprotein-containing complex
G0033209biological_processtumor necrosis factor-mediated signaling pathway
G0034774cellular_componentsecretory granule lumen
G0035578cellular_componentazurophil granule lumen
G0038187molecular_functionpattern recognition receptor activity
G0042104biological_processpositive regulation of activated T cell proliferation
G0042742biological_processdefense response to bacterium
G0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0042981biological_processregulation of apoptotic process
G0043025cellular_componentneuronal cell body
G0043065biological_processpositive regulation of apoptotic process
G0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
G0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
G0044325molecular_functiontransmembrane transporter binding
G0044351biological_processmacropinocytosis
G0044546biological_processNLRP3 inflammasome complex assembly
G0046330biological_processpositive regulation of JNK cascade
G0046456biological_processicosanoid biosynthetic process
G0046983molecular_functionprotein dimerization activity
G0050727biological_processregulation of inflammatory response
G0050729biological_processpositive regulation of inflammatory response
G0050766biological_processpositive regulation of phagocytosis
G0050829biological_processdefense response to Gram-negative bacterium
G0050870biological_processpositive regulation of T cell activation
G0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
G0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
G0051260biological_processprotein homooligomerization
G0051607biological_processdefense response to virus
G0061702cellular_componentcanonical inflammasome complex
G0070269biological_processpyroptotic inflammatory response
G0070374biological_processpositive regulation of ERK1 and ERK2 cascade
G0070700molecular_functionBMP receptor binding
G0071222biological_processcellular response to lipopolysaccharide
G0071347biological_processcellular response to interleukin-1
G0071356biological_processcellular response to tumor necrosis factor
G0071901biological_processnegative regulation of protein serine/threonine kinase activity
G0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
G0072558cellular_componentNLRP1 inflammasome complex
G0072559cellular_componentNLRP3 inflammasome complex
G0090200biological_processpositive regulation of release of cytochrome c from mitochondria
G0097169cellular_componentAIM2 inflammasome complex
G0097190biological_processapoptotic signaling pathway
G0097193biological_processintrinsic apoptotic signaling pathway
G0140608molecular_functioncysteine-type endopeptidase activator activity
G0140632biological_processcanonical inflammasome complex assembly
G0140738cellular_componentNLRP6 inflammasome complex
G1900016biological_processnegative regulation of cytokine production involved in inflammatory response
G1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
G2000406biological_processpositive regulation of T cell migration
G2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
G2001242biological_processregulation of intrinsic apoptotic signaling pathway
H0000139cellular_componentGolgi membrane
H0001773biological_processmyeloid dendritic cell activation
H0002020molecular_functionprotease binding
H0002218biological_processactivation of innate immune response
H0002221biological_processpattern recognition receptor signaling pathway
H0002230biological_processpositive regulation of defense response to virus by host
H0002277biological_processmyeloid dendritic cell activation involved in immune response
H0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
H0002821biological_processpositive regulation of adaptive immune response
H0005138molecular_functioninterleukin-6 receptor binding
H0005515molecular_functionprotein binding
H0005523molecular_functiontropomyosin binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005730cellular_componentnucleolus
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005783cellular_componentendoplasmic reticulum
H0005829cellular_componentcytosol
H0005874cellular_componentmicrotubule
H0006915biological_processapoptotic process
H0006954biological_processinflammatory response
H0007165biological_processsignal transduction
H0007231biological_processosmosensory signaling pathway
H0008385cellular_componentIkappaB kinase complex
H0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
H0017024molecular_functionmyosin I binding
H0019899molecular_functionenzyme binding
H0030674molecular_functionprotein-macromolecule adaptor activity
H0030838biological_processpositive regulation of actin filament polymerization
H0031647biological_processregulation of protein stability
H0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
H0032090molecular_functionPyrin domain binding
H0032688biological_processnegative regulation of interferon-beta production
H0032722biological_processpositive regulation of chemokine production
H0032729biological_processpositive regulation of type II interferon production
H0032731biological_processpositive regulation of interleukin-1 beta production
H0032733biological_processpositive regulation of interleukin-10 production
H0032755biological_processpositive regulation of interleukin-6 production
H0032757biological_processpositive regulation of interleukin-8 production
H0032760biological_processpositive regulation of tumor necrosis factor production
H0032991cellular_componentprotein-containing complex
H0033209biological_processtumor necrosis factor-mediated signaling pathway
H0034774cellular_componentsecretory granule lumen
H0035578cellular_componentazurophil granule lumen
H0038187molecular_functionpattern recognition receptor activity
H0042104biological_processpositive regulation of activated T cell proliferation
H0042742biological_processdefense response to bacterium
H0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
H0042802molecular_functionidentical protein binding
H0042803molecular_functionprotein homodimerization activity
H0042981biological_processregulation of apoptotic process
H0043025cellular_componentneuronal cell body
H0043065biological_processpositive regulation of apoptotic process
H0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
H0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
H0044325molecular_functiontransmembrane transporter binding
H0044351biological_processmacropinocytosis
H0044546biological_processNLRP3 inflammasome complex assembly
H0046330biological_processpositive regulation of JNK cascade
H0046456biological_processicosanoid biosynthetic process
H0046983molecular_functionprotein dimerization activity
H0050727biological_processregulation of inflammatory response
H0050729biological_processpositive regulation of inflammatory response
H0050766biological_processpositive regulation of phagocytosis
H0050829biological_processdefense response to Gram-negative bacterium
H0050870biological_processpositive regulation of T cell activation
H0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
H0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
H0051260biological_processprotein homooligomerization
H0051607biological_processdefense response to virus
H0061702cellular_componentcanonical inflammasome complex
H0070269biological_processpyroptotic inflammatory response
H0070374biological_processpositive regulation of ERK1 and ERK2 cascade
H0070700molecular_functionBMP receptor binding
H0071222biological_processcellular response to lipopolysaccharide
H0071347biological_processcellular response to interleukin-1
H0071356biological_processcellular response to tumor necrosis factor
H0071901biological_processnegative regulation of protein serine/threonine kinase activity
H0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
H0072558cellular_componentNLRP1 inflammasome complex
H0072559cellular_componentNLRP3 inflammasome complex
H0090200biological_processpositive regulation of release of cytochrome c from mitochondria
H0097169cellular_componentAIM2 inflammasome complex
H0097190biological_processapoptotic signaling pathway
H0097193biological_processintrinsic apoptotic signaling pathway
H0140608molecular_functioncysteine-type endopeptidase activator activity
H0140632biological_processcanonical inflammasome complex assembly
H0140738cellular_componentNLRP6 inflammasome complex
H1900016biological_processnegative regulation of cytokine production involved in inflammatory response
H1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
H2000406biological_processpositive regulation of T cell migration
H2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
H2001242biological_processregulation of intrinsic apoptotic signaling pathway
I0000139cellular_componentGolgi membrane
I0001773biological_processmyeloid dendritic cell activation
I0002020molecular_functionprotease binding
I0002218biological_processactivation of innate immune response
I0002221biological_processpattern recognition receptor signaling pathway
I0002230biological_processpositive regulation of defense response to virus by host
I0002277biological_processmyeloid dendritic cell activation involved in immune response
I0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
I0002821biological_processpositive regulation of adaptive immune response
I0005138molecular_functioninterleukin-6 receptor binding
I0005515molecular_functionprotein binding
I0005523molecular_functiontropomyosin binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005730cellular_componentnucleolus
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005783cellular_componentendoplasmic reticulum
I0005829cellular_componentcytosol
I0005874cellular_componentmicrotubule
I0006915biological_processapoptotic process
I0006954biological_processinflammatory response
I0007165biological_processsignal transduction
I0007231biological_processosmosensory signaling pathway
I0008385cellular_componentIkappaB kinase complex
I0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
I0017024molecular_functionmyosin I binding
I0019899molecular_functionenzyme binding
I0030674molecular_functionprotein-macromolecule adaptor activity
I0030838biological_processpositive regulation of actin filament polymerization
I0031647biological_processregulation of protein stability
I0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
I0032090molecular_functionPyrin domain binding
I0032688biological_processnegative regulation of interferon-beta production
I0032722biological_processpositive regulation of chemokine production
I0032729biological_processpositive regulation of type II interferon production
I0032731biological_processpositive regulation of interleukin-1 beta production
I0032733biological_processpositive regulation of interleukin-10 production
I0032755biological_processpositive regulation of interleukin-6 production
I0032757biological_processpositive regulation of interleukin-8 production
I0032760biological_processpositive regulation of tumor necrosis factor production
I0032991cellular_componentprotein-containing complex
I0033209biological_processtumor necrosis factor-mediated signaling pathway
I0034774cellular_componentsecretory granule lumen
I0035578cellular_componentazurophil granule lumen
I0038187molecular_functionpattern recognition receptor activity
I0042104biological_processpositive regulation of activated T cell proliferation
I0042742biological_processdefense response to bacterium
I0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
I0042802molecular_functionidentical protein binding
I0042803molecular_functionprotein homodimerization activity
I0042981biological_processregulation of apoptotic process
I0043025cellular_componentneuronal cell body
I0043065biological_processpositive regulation of apoptotic process
I0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
I0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
I0044325molecular_functiontransmembrane transporter binding
I0044351biological_processmacropinocytosis
I0044546biological_processNLRP3 inflammasome complex assembly
I0046330biological_processpositive regulation of JNK cascade
I0046456biological_processicosanoid biosynthetic process
I0046983molecular_functionprotein dimerization activity
I0050727biological_processregulation of inflammatory response
I0050729biological_processpositive regulation of inflammatory response
I0050766biological_processpositive regulation of phagocytosis
I0050829biological_processdefense response to Gram-negative bacterium
I0050870biological_processpositive regulation of T cell activation
I0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
I0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
I0051260biological_processprotein homooligomerization
I0051607biological_processdefense response to virus
I0061702cellular_componentcanonical inflammasome complex
I0070269biological_processpyroptotic inflammatory response
I0070374biological_processpositive regulation of ERK1 and ERK2 cascade
I0070700molecular_functionBMP receptor binding
I0071222biological_processcellular response to lipopolysaccharide
I0071347biological_processcellular response to interleukin-1
I0071356biological_processcellular response to tumor necrosis factor
I0071901biological_processnegative regulation of protein serine/threonine kinase activity
I0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
I0072558cellular_componentNLRP1 inflammasome complex
I0072559cellular_componentNLRP3 inflammasome complex
I0090200biological_processpositive regulation of release of cytochrome c from mitochondria
I0097169cellular_componentAIM2 inflammasome complex
I0097190biological_processapoptotic signaling pathway
I0097193biological_processintrinsic apoptotic signaling pathway
I0140608molecular_functioncysteine-type endopeptidase activator activity
I0140632biological_processcanonical inflammasome complex assembly
I0140738cellular_componentNLRP6 inflammasome complex
I1900016biological_processnegative regulation of cytokine production involved in inflammatory response
I1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
I2000406biological_processpositive regulation of T cell migration
I2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
I2001242biological_processregulation of intrinsic apoptotic signaling pathway
J0000139cellular_componentGolgi membrane
J0001773biological_processmyeloid dendritic cell activation
J0002020molecular_functionprotease binding
J0002218biological_processactivation of innate immune response
J0002221biological_processpattern recognition receptor signaling pathway
J0002230biological_processpositive regulation of defense response to virus by host
J0002277biological_processmyeloid dendritic cell activation involved in immune response
J0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
J0002821biological_processpositive regulation of adaptive immune response
J0005138molecular_functioninterleukin-6 receptor binding
J0005515molecular_functionprotein binding
J0005523molecular_functiontropomyosin binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005730cellular_componentnucleolus
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005783cellular_componentendoplasmic reticulum
J0005829cellular_componentcytosol
J0005874cellular_componentmicrotubule
J0006915biological_processapoptotic process
J0006954biological_processinflammatory response
J0007165biological_processsignal transduction
J0007231biological_processosmosensory signaling pathway
J0008385cellular_componentIkappaB kinase complex
J0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
J0017024molecular_functionmyosin I binding
J0019899molecular_functionenzyme binding
J0030674molecular_functionprotein-macromolecule adaptor activity
J0030838biological_processpositive regulation of actin filament polymerization
J0031647biological_processregulation of protein stability
J0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
J0032090molecular_functionPyrin domain binding
J0032688biological_processnegative regulation of interferon-beta production
J0032722biological_processpositive regulation of chemokine production
J0032729biological_processpositive regulation of type II interferon production
J0032731biological_processpositive regulation of interleukin-1 beta production
J0032733biological_processpositive regulation of interleukin-10 production
J0032755biological_processpositive regulation of interleukin-6 production
J0032757biological_processpositive regulation of interleukin-8 production
J0032760biological_processpositive regulation of tumor necrosis factor production
J0032991cellular_componentprotein-containing complex
J0033209biological_processtumor necrosis factor-mediated signaling pathway
J0034774cellular_componentsecretory granule lumen
J0035578cellular_componentazurophil granule lumen
J0038187molecular_functionpattern recognition receptor activity
J0042104biological_processpositive regulation of activated T cell proliferation
J0042742biological_processdefense response to bacterium
J0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
J0042802molecular_functionidentical protein binding
J0042803molecular_functionprotein homodimerization activity
J0042981biological_processregulation of apoptotic process
J0043025cellular_componentneuronal cell body
J0043065biological_processpositive regulation of apoptotic process
J0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
J0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
J0044325molecular_functiontransmembrane transporter binding
J0044351biological_processmacropinocytosis
J0044546biological_processNLRP3 inflammasome complex assembly
J0046330biological_processpositive regulation of JNK cascade
J0046456biological_processicosanoid biosynthetic process
J0046983molecular_functionprotein dimerization activity
J0050727biological_processregulation of inflammatory response
J0050729biological_processpositive regulation of inflammatory response
J0050766biological_processpositive regulation of phagocytosis
J0050829biological_processdefense response to Gram-negative bacterium
J0050870biological_processpositive regulation of T cell activation
J0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
J0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
J0051260biological_processprotein homooligomerization
J0051607biological_processdefense response to virus
J0061702cellular_componentcanonical inflammasome complex
J0070269biological_processpyroptotic inflammatory response
J0070374biological_processpositive regulation of ERK1 and ERK2 cascade
J0070700molecular_functionBMP receptor binding
J0071222biological_processcellular response to lipopolysaccharide
J0071347biological_processcellular response to interleukin-1
J0071356biological_processcellular response to tumor necrosis factor
J0071901biological_processnegative regulation of protein serine/threonine kinase activity
J0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
J0072558cellular_componentNLRP1 inflammasome complex
J0072559cellular_componentNLRP3 inflammasome complex
J0090200biological_processpositive regulation of release of cytochrome c from mitochondria
J0097169cellular_componentAIM2 inflammasome complex
J0097190biological_processapoptotic signaling pathway
J0097193biological_processintrinsic apoptotic signaling pathway
J0140608molecular_functioncysteine-type endopeptidase activator activity
J0140632biological_processcanonical inflammasome complex assembly
J0140738cellular_componentNLRP6 inflammasome complex
J1900016biological_processnegative regulation of cytokine production involved in inflammatory response
J1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
J2000406biological_processpositive regulation of T cell migration
J2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
J2001242biological_processregulation of intrinsic apoptotic signaling pathway
K0000139cellular_componentGolgi membrane
K0001773biological_processmyeloid dendritic cell activation
K0002020molecular_functionprotease binding
K0002218biological_processactivation of innate immune response
K0002221biological_processpattern recognition receptor signaling pathway
K0002230biological_processpositive regulation of defense response to virus by host
K0002277biological_processmyeloid dendritic cell activation involved in immune response
K0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
K0002821biological_processpositive regulation of adaptive immune response
K0005138molecular_functioninterleukin-6 receptor binding
K0005515molecular_functionprotein binding
K0005523molecular_functiontropomyosin binding
K0005576cellular_componentextracellular region
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005730cellular_componentnucleolus
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005783cellular_componentendoplasmic reticulum
K0005829cellular_componentcytosol
K0005874cellular_componentmicrotubule
K0006915biological_processapoptotic process
K0006954biological_processinflammatory response
K0007165biological_processsignal transduction
K0007231biological_processosmosensory signaling pathway
K0008385cellular_componentIkappaB kinase complex
K0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
K0017024molecular_functionmyosin I binding
K0019899molecular_functionenzyme binding
K0030674molecular_functionprotein-macromolecule adaptor activity
K0030838biological_processpositive regulation of actin filament polymerization
K0031647biological_processregulation of protein stability
K0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
K0032090molecular_functionPyrin domain binding
K0032688biological_processnegative regulation of interferon-beta production
K0032722biological_processpositive regulation of chemokine production
K0032729biological_processpositive regulation of type II interferon production
K0032731biological_processpositive regulation of interleukin-1 beta production
K0032733biological_processpositive regulation of interleukin-10 production
K0032755biological_processpositive regulation of interleukin-6 production
K0032757biological_processpositive regulation of interleukin-8 production
K0032760biological_processpositive regulation of tumor necrosis factor production
K0032991cellular_componentprotein-containing complex
K0033209biological_processtumor necrosis factor-mediated signaling pathway
K0034774cellular_componentsecretory granule lumen
K0035578cellular_componentazurophil granule lumen
K0038187molecular_functionpattern recognition receptor activity
K0042104biological_processpositive regulation of activated T cell proliferation
K0042742biological_processdefense response to bacterium
K0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
K0042802molecular_functionidentical protein binding
K0042803molecular_functionprotein homodimerization activity
K0042981biological_processregulation of apoptotic process
K0043025cellular_componentneuronal cell body
K0043065biological_processpositive regulation of apoptotic process
K0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
K0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
K0044325molecular_functiontransmembrane transporter binding
K0044351biological_processmacropinocytosis
K0044546biological_processNLRP3 inflammasome complex assembly
K0046330biological_processpositive regulation of JNK cascade
K0046456biological_processicosanoid biosynthetic process
K0046983molecular_functionprotein dimerization activity
K0050727biological_processregulation of inflammatory response
K0050729biological_processpositive regulation of inflammatory response
K0050766biological_processpositive regulation of phagocytosis
K0050829biological_processdefense response to Gram-negative bacterium
K0050870biological_processpositive regulation of T cell activation
K0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
K0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
K0051260biological_processprotein homooligomerization
K0051607biological_processdefense response to virus
K0061702cellular_componentcanonical inflammasome complex
K0070269biological_processpyroptotic inflammatory response
K0070374biological_processpositive regulation of ERK1 and ERK2 cascade
K0070700molecular_functionBMP receptor binding
K0071222biological_processcellular response to lipopolysaccharide
K0071347biological_processcellular response to interleukin-1
K0071356biological_processcellular response to tumor necrosis factor
K0071901biological_processnegative regulation of protein serine/threonine kinase activity
K0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
K0072558cellular_componentNLRP1 inflammasome complex
K0072559cellular_componentNLRP3 inflammasome complex
K0090200biological_processpositive regulation of release of cytochrome c from mitochondria
K0097169cellular_componentAIM2 inflammasome complex
K0097190biological_processapoptotic signaling pathway
K0097193biological_processintrinsic apoptotic signaling pathway
K0140608molecular_functioncysteine-type endopeptidase activator activity
K0140632biological_processcanonical inflammasome complex assembly
K0140738cellular_componentNLRP6 inflammasome complex
K1900016biological_processnegative regulation of cytokine production involved in inflammatory response
K1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
K2000406biological_processpositive regulation of T cell migration
K2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
K2001242biological_processregulation of intrinsic apoptotic signaling pathway
L0000139cellular_componentGolgi membrane
L0001773biological_processmyeloid dendritic cell activation
L0002020molecular_functionprotease binding
L0002218biological_processactivation of innate immune response
L0002221biological_processpattern recognition receptor signaling pathway
L0002230biological_processpositive regulation of defense response to virus by host
L0002277biological_processmyeloid dendritic cell activation involved in immune response
L0002588biological_processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
L0002821biological_processpositive regulation of adaptive immune response
L0005138molecular_functioninterleukin-6 receptor binding
L0005515molecular_functionprotein binding
L0005523molecular_functiontropomyosin binding
L0005576cellular_componentextracellular region
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005730cellular_componentnucleolus
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005783cellular_componentendoplasmic reticulum
L0005829cellular_componentcytosol
L0005874cellular_componentmicrotubule
L0006915biological_processapoptotic process
L0006954biological_processinflammatory response
L0007165biological_processsignal transduction
L0007231biological_processosmosensory signaling pathway
L0008385cellular_componentIkappaB kinase complex
L0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
L0017024molecular_functionmyosin I binding
L0019899molecular_functionenzyme binding
L0030674molecular_functionprotein-macromolecule adaptor activity
L0030838biological_processpositive regulation of actin filament polymerization
L0031647biological_processregulation of protein stability
L0032088biological_processobsolete negative regulation of NF-kappaB transcription factor activity
L0032090molecular_functionPyrin domain binding
L0032688biological_processnegative regulation of interferon-beta production
L0032722biological_processpositive regulation of chemokine production
L0032729biological_processpositive regulation of type II interferon production
L0032731biological_processpositive regulation of interleukin-1 beta production
L0032733biological_processpositive regulation of interleukin-10 production
L0032755biological_processpositive regulation of interleukin-6 production
L0032757biological_processpositive regulation of interleukin-8 production
L0032760biological_processpositive regulation of tumor necrosis factor production
L0032991cellular_componentprotein-containing complex
L0033209biological_processtumor necrosis factor-mediated signaling pathway
L0034774cellular_componentsecretory granule lumen
L0035578cellular_componentazurophil granule lumen
L0038187molecular_functionpattern recognition receptor activity
L0042104biological_processpositive regulation of activated T cell proliferation
L0042742biological_processdefense response to bacterium
L0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
L0042802molecular_functionidentical protein binding
L0042803molecular_functionprotein homodimerization activity
L0042981biological_processregulation of apoptotic process
L0043025cellular_componentneuronal cell body
L0043065biological_processpositive regulation of apoptotic process
L0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
L0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
L0044325molecular_functiontransmembrane transporter binding
L0044351biological_processmacropinocytosis
L0044546biological_processNLRP3 inflammasome complex assembly
L0046330biological_processpositive regulation of JNK cascade
L0046456biological_processicosanoid biosynthetic process
L0046983molecular_functionprotein dimerization activity
L0050727biological_processregulation of inflammatory response
L0050729biological_processpositive regulation of inflammatory response
L0050766biological_processpositive regulation of phagocytosis
L0050829biological_processdefense response to Gram-negative bacterium
L0050870biological_processpositive regulation of T cell activation
L0051091biological_processobsolete positive regulation of DNA-binding transcription factor activity
L0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
L0051260biological_processprotein homooligomerization
L0051607biological_processdefense response to virus
L0061702cellular_componentcanonical inflammasome complex
L0070269biological_processpyroptotic inflammatory response
L0070374biological_processpositive regulation of ERK1 and ERK2 cascade
L0070700molecular_functionBMP receptor binding
L0071222biological_processcellular response to lipopolysaccharide
L0071347biological_processcellular response to interleukin-1
L0071356biological_processcellular response to tumor necrosis factor
L0071901biological_processnegative regulation of protein serine/threonine kinase activity
L0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
L0072558cellular_componentNLRP1 inflammasome complex
L0072559cellular_componentNLRP3 inflammasome complex
L0090200biological_processpositive regulation of release of cytochrome c from mitochondria
L0097169cellular_componentAIM2 inflammasome complex
L0097190biological_processapoptotic signaling pathway
L0097193biological_processintrinsic apoptotic signaling pathway
L0140608molecular_functioncysteine-type endopeptidase activator activity
L0140632biological_processcanonical inflammasome complex assembly
L0140738cellular_componentNLRP6 inflammasome complex
L1900016biological_processnegative regulation of cytokine production involved in inflammatory response
L1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
L2000406biological_processpositive regulation of T cell migration
L2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
L2001242biological_processregulation of intrinsic apoptotic signaling pathway
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25847972","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

251174

PDB entries from 2026-03-25

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