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9WZ6

Full-length Caspase-1-CARD filament

Functional Information from GO Data
ChainGOidnamespacecontents
A0002221biological_processpattern recognition receptor signaling pathway
A0004175molecular_functionendopeptidase activity
A0004197molecular_functioncysteine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0007165biological_processsignal transduction
A0007231biological_processosmosensory signaling pathway
A0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
A0016485biological_processprotein processing
A0016540biological_processprotein autoprocessing
A0019899molecular_functionenzyme binding
A0019900molecular_functionkinase binding
A0019955molecular_functioncytokine binding
A0032496biological_processresponse to lipopolysaccharide
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032741biological_processpositive regulation of interleukin-18 production
A0032991cellular_componentprotein-containing complex
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0046456biological_processicosanoid biosynthetic process
A0050700molecular_functionCARD domain binding
A0050727biological_processregulation of inflammatory response
A0050729biological_processpositive regulation of inflammatory response
A0051604biological_processprotein maturation
A0051607biological_processdefense response to virus
A0070269biological_processpyroptotic inflammatory response
A0071222biological_processcellular response to lipopolysaccharide
A0071260biological_processcellular response to mechanical stimulus
A0071310biological_processobsolete cellular response to organic substance
A0071346biological_processcellular response to type II interferon
A0072557cellular_componentIPAF inflammasome complex
A0072558cellular_componentNLRP1 inflammasome complex
A0072559cellular_componentNLRP3 inflammasome complex
A0097169cellular_componentAIM2 inflammasome complex
A0097179cellular_componentprotease inhibitor complex
A0140447biological_processcytokine precursor processing
A0140448biological_processsignaling receptor ligand precursor processing
A0140970biological_processAIM2 inflammasome complex assembly
A1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
A1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
B0002221biological_processpattern recognition receptor signaling pathway
B0004175molecular_functionendopeptidase activity
B0004197molecular_functioncysteine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005874cellular_componentmicrotubule
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0007165biological_processsignal transduction
B0007231biological_processosmosensory signaling pathway
B0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
B0016485biological_processprotein processing
B0016540biological_processprotein autoprocessing
B0019899molecular_functionenzyme binding
B0019900molecular_functionkinase binding
B0019955molecular_functioncytokine binding
B0032496biological_processresponse to lipopolysaccharide
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032741biological_processpositive regulation of interleukin-18 production
B0032991cellular_componentprotein-containing complex
B0042742biological_processdefense response to bacterium
B0042802molecular_functionidentical protein binding
B0043065biological_processpositive regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0046456biological_processicosanoid biosynthetic process
B0050700molecular_functionCARD domain binding
B0050727biological_processregulation of inflammatory response
B0050729biological_processpositive regulation of inflammatory response
B0051604biological_processprotein maturation
B0051607biological_processdefense response to virus
B0070269biological_processpyroptotic inflammatory response
B0071222biological_processcellular response to lipopolysaccharide
B0071260biological_processcellular response to mechanical stimulus
B0071310biological_processobsolete cellular response to organic substance
B0071346biological_processcellular response to type II interferon
B0072557cellular_componentIPAF inflammasome complex
B0072558cellular_componentNLRP1 inflammasome complex
B0072559cellular_componentNLRP3 inflammasome complex
B0097169cellular_componentAIM2 inflammasome complex
B0097179cellular_componentprotease inhibitor complex
B0140447biological_processcytokine precursor processing
B0140448biological_processsignaling receptor ligand precursor processing
B0140970biological_processAIM2 inflammasome complex assembly
B1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
B1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
C0002221biological_processpattern recognition receptor signaling pathway
C0004175molecular_functionendopeptidase activity
C0004197molecular_functioncysteine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005874cellular_componentmicrotubule
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0006915biological_processapoptotic process
C0006954biological_processinflammatory response
C0007165biological_processsignal transduction
C0007231biological_processosmosensory signaling pathway
C0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
C0016485biological_processprotein processing
C0016540biological_processprotein autoprocessing
C0019899molecular_functionenzyme binding
C0019900molecular_functionkinase binding
C0019955molecular_functioncytokine binding
C0032496biological_processresponse to lipopolysaccharide
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032741biological_processpositive regulation of interleukin-18 production
C0032991cellular_componentprotein-containing complex
C0042742biological_processdefense response to bacterium
C0042802molecular_functionidentical protein binding
C0043065biological_processpositive regulation of apoptotic process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0046456biological_processicosanoid biosynthetic process
C0050700molecular_functionCARD domain binding
C0050727biological_processregulation of inflammatory response
C0050729biological_processpositive regulation of inflammatory response
C0051604biological_processprotein maturation
C0051607biological_processdefense response to virus
C0070269biological_processpyroptotic inflammatory response
C0071222biological_processcellular response to lipopolysaccharide
C0071260biological_processcellular response to mechanical stimulus
C0071310biological_processobsolete cellular response to organic substance
C0071346biological_processcellular response to type II interferon
C0072557cellular_componentIPAF inflammasome complex
C0072558cellular_componentNLRP1 inflammasome complex
C0072559cellular_componentNLRP3 inflammasome complex
C0097169cellular_componentAIM2 inflammasome complex
C0097179cellular_componentprotease inhibitor complex
C0140447biological_processcytokine precursor processing
C0140448biological_processsignaling receptor ligand precursor processing
C0140970biological_processAIM2 inflammasome complex assembly
C1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
C1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
D0002221biological_processpattern recognition receptor signaling pathway
D0004175molecular_functionendopeptidase activity
D0004197molecular_functioncysteine-type endopeptidase activity
D0005515molecular_functionprotein binding
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005874cellular_componentmicrotubule
D0005886cellular_componentplasma membrane
D0006508biological_processproteolysis
D0006915biological_processapoptotic process
D0006954biological_processinflammatory response
D0007165biological_processsignal transduction
D0007231biological_processosmosensory signaling pathway
D0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
D0016485biological_processprotein processing
D0016540biological_processprotein autoprocessing
D0019899molecular_functionenzyme binding
D0019900molecular_functionkinase binding
D0019955molecular_functioncytokine binding
D0032496biological_processresponse to lipopolysaccharide
D0032731biological_processpositive regulation of interleukin-1 beta production
D0032741biological_processpositive regulation of interleukin-18 production
D0032991cellular_componentprotein-containing complex
D0042742biological_processdefense response to bacterium
D0042802molecular_functionidentical protein binding
D0043065biological_processpositive regulation of apoptotic process
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0046456biological_processicosanoid biosynthetic process
D0050700molecular_functionCARD domain binding
D0050727biological_processregulation of inflammatory response
D0050729biological_processpositive regulation of inflammatory response
D0051604biological_processprotein maturation
D0051607biological_processdefense response to virus
D0070269biological_processpyroptotic inflammatory response
D0071222biological_processcellular response to lipopolysaccharide
D0071260biological_processcellular response to mechanical stimulus
D0071310biological_processobsolete cellular response to organic substance
D0071346biological_processcellular response to type II interferon
D0072557cellular_componentIPAF inflammasome complex
D0072558cellular_componentNLRP1 inflammasome complex
D0072559cellular_componentNLRP3 inflammasome complex
D0097169cellular_componentAIM2 inflammasome complex
D0097179cellular_componentprotease inhibitor complex
D0140447biological_processcytokine precursor processing
D0140448biological_processsignaling receptor ligand precursor processing
D0140970biological_processAIM2 inflammasome complex assembly
D1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
D1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
E0002221biological_processpattern recognition receptor signaling pathway
E0004175molecular_functionendopeptidase activity
E0004197molecular_functioncysteine-type endopeptidase activity
E0005515molecular_functionprotein binding
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005874cellular_componentmicrotubule
E0005886cellular_componentplasma membrane
E0006508biological_processproteolysis
E0006915biological_processapoptotic process
E0006954biological_processinflammatory response
E0007165biological_processsignal transduction
E0007231biological_processosmosensory signaling pathway
E0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
E0016485biological_processprotein processing
E0016540biological_processprotein autoprocessing
E0019899molecular_functionenzyme binding
E0019900molecular_functionkinase binding
E0019955molecular_functioncytokine binding
E0032496biological_processresponse to lipopolysaccharide
E0032731biological_processpositive regulation of interleukin-1 beta production
E0032741biological_processpositive regulation of interleukin-18 production
E0032991cellular_componentprotein-containing complex
E0042742biological_processdefense response to bacterium
E0042802molecular_functionidentical protein binding
E0043065biological_processpositive regulation of apoptotic process
E0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
E0046456biological_processicosanoid biosynthetic process
E0050700molecular_functionCARD domain binding
E0050727biological_processregulation of inflammatory response
E0050729biological_processpositive regulation of inflammatory response
E0051604biological_processprotein maturation
E0051607biological_processdefense response to virus
E0070269biological_processpyroptotic inflammatory response
E0071222biological_processcellular response to lipopolysaccharide
E0071260biological_processcellular response to mechanical stimulus
E0071310biological_processobsolete cellular response to organic substance
E0071346biological_processcellular response to type II interferon
E0072557cellular_componentIPAF inflammasome complex
E0072558cellular_componentNLRP1 inflammasome complex
E0072559cellular_componentNLRP3 inflammasome complex
E0097169cellular_componentAIM2 inflammasome complex
E0097179cellular_componentprotease inhibitor complex
E0140447biological_processcytokine precursor processing
E0140448biological_processsignaling receptor ligand precursor processing
E0140970biological_processAIM2 inflammasome complex assembly
E1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
E1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
F0002221biological_processpattern recognition receptor signaling pathway
F0004175molecular_functionendopeptidase activity
F0004197molecular_functioncysteine-type endopeptidase activity
F0005515molecular_functionprotein binding
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005874cellular_componentmicrotubule
F0005886cellular_componentplasma membrane
F0006508biological_processproteolysis
F0006915biological_processapoptotic process
F0006954biological_processinflammatory response
F0007165biological_processsignal transduction
F0007231biological_processosmosensory signaling pathway
F0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
F0016485biological_processprotein processing
F0016540biological_processprotein autoprocessing
F0019899molecular_functionenzyme binding
F0019900molecular_functionkinase binding
F0019955molecular_functioncytokine binding
F0032496biological_processresponse to lipopolysaccharide
F0032731biological_processpositive regulation of interleukin-1 beta production
F0032741biological_processpositive regulation of interleukin-18 production
F0032991cellular_componentprotein-containing complex
F0042742biological_processdefense response to bacterium
F0042802molecular_functionidentical protein binding
F0043065biological_processpositive regulation of apoptotic process
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0046456biological_processicosanoid biosynthetic process
F0050700molecular_functionCARD domain binding
F0050727biological_processregulation of inflammatory response
F0050729biological_processpositive regulation of inflammatory response
F0051604biological_processprotein maturation
F0051607biological_processdefense response to virus
F0070269biological_processpyroptotic inflammatory response
F0071222biological_processcellular response to lipopolysaccharide
F0071260biological_processcellular response to mechanical stimulus
F0071310biological_processobsolete cellular response to organic substance
F0071346biological_processcellular response to type II interferon
F0072557cellular_componentIPAF inflammasome complex
F0072558cellular_componentNLRP1 inflammasome complex
F0072559cellular_componentNLRP3 inflammasome complex
F0097169cellular_componentAIM2 inflammasome complex
F0097179cellular_componentprotease inhibitor complex
F0140447biological_processcytokine precursor processing
F0140448biological_processsignaling receptor ligand precursor processing
F0140970biological_processAIM2 inflammasome complex assembly
F1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
F1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
G0002221biological_processpattern recognition receptor signaling pathway
G0004175molecular_functionendopeptidase activity
G0004197molecular_functioncysteine-type endopeptidase activity
G0005515molecular_functionprotein binding
G0005730cellular_componentnucleolus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005874cellular_componentmicrotubule
G0005886cellular_componentplasma membrane
G0006508biological_processproteolysis
G0006915biological_processapoptotic process
G0006954biological_processinflammatory response
G0007165biological_processsignal transduction
G0007231biological_processosmosensory signaling pathway
G0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
G0016485biological_processprotein processing
G0016540biological_processprotein autoprocessing
G0019899molecular_functionenzyme binding
G0019900molecular_functionkinase binding
G0019955molecular_functioncytokine binding
G0032496biological_processresponse to lipopolysaccharide
G0032731biological_processpositive regulation of interleukin-1 beta production
G0032741biological_processpositive regulation of interleukin-18 production
G0032991cellular_componentprotein-containing complex
G0042742biological_processdefense response to bacterium
G0042802molecular_functionidentical protein binding
G0043065biological_processpositive regulation of apoptotic process
G0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
G0046456biological_processicosanoid biosynthetic process
G0050700molecular_functionCARD domain binding
G0050727biological_processregulation of inflammatory response
G0050729biological_processpositive regulation of inflammatory response
G0051604biological_processprotein maturation
G0051607biological_processdefense response to virus
G0070269biological_processpyroptotic inflammatory response
G0071222biological_processcellular response to lipopolysaccharide
G0071260biological_processcellular response to mechanical stimulus
G0071310biological_processobsolete cellular response to organic substance
G0071346biological_processcellular response to type II interferon
G0072557cellular_componentIPAF inflammasome complex
G0072558cellular_componentNLRP1 inflammasome complex
G0072559cellular_componentNLRP3 inflammasome complex
G0097169cellular_componentAIM2 inflammasome complex
G0097179cellular_componentprotease inhibitor complex
G0140447biological_processcytokine precursor processing
G0140448biological_processsignaling receptor ligand precursor processing
G0140970biological_processAIM2 inflammasome complex assembly
G1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
G1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
H0002221biological_processpattern recognition receptor signaling pathway
H0004175molecular_functionendopeptidase activity
H0004197molecular_functioncysteine-type endopeptidase activity
H0005515molecular_functionprotein binding
H0005730cellular_componentnucleolus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005874cellular_componentmicrotubule
H0005886cellular_componentplasma membrane
H0006508biological_processproteolysis
H0006915biological_processapoptotic process
H0006954biological_processinflammatory response
H0007165biological_processsignal transduction
H0007231biological_processosmosensory signaling pathway
H0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
H0016485biological_processprotein processing
H0016540biological_processprotein autoprocessing
H0019899molecular_functionenzyme binding
H0019900molecular_functionkinase binding
H0019955molecular_functioncytokine binding
H0032496biological_processresponse to lipopolysaccharide
H0032731biological_processpositive regulation of interleukin-1 beta production
H0032741biological_processpositive regulation of interleukin-18 production
H0032991cellular_componentprotein-containing complex
H0042742biological_processdefense response to bacterium
H0042802molecular_functionidentical protein binding
H0043065biological_processpositive regulation of apoptotic process
H0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
H0046456biological_processicosanoid biosynthetic process
H0050700molecular_functionCARD domain binding
H0050727biological_processregulation of inflammatory response
H0050729biological_processpositive regulation of inflammatory response
H0051604biological_processprotein maturation
H0051607biological_processdefense response to virus
H0070269biological_processpyroptotic inflammatory response
H0071222biological_processcellular response to lipopolysaccharide
H0071260biological_processcellular response to mechanical stimulus
H0071310biological_processobsolete cellular response to organic substance
H0071346biological_processcellular response to type II interferon
H0072557cellular_componentIPAF inflammasome complex
H0072558cellular_componentNLRP1 inflammasome complex
H0072559cellular_componentNLRP3 inflammasome complex
H0097169cellular_componentAIM2 inflammasome complex
H0097179cellular_componentprotease inhibitor complex
H0140447biological_processcytokine precursor processing
H0140448biological_processsignaling receptor ligand precursor processing
H0140970biological_processAIM2 inflammasome complex assembly
H1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
H1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00455
Number of Residues12
DetailsAMP_BINDING Putative AMP-binding domain signature. MPTSSGSEGnVK
ChainResidueDetails
AMET123-LYS134

site_idPS01121
Number of Residues15
DetailsCASPASE_HIS Caspase family histidine active site. HktsdStfLvFMSHG
ChainResidueDetails
AHIS224-GLY238

site_idPS01122
Number of Residues12
DetailsCASPASE_CYS Caspase family cysteine active site. KPKVIIIQACRG
ChainResidueDetails
ALYS276-GLY287

Catalytic Information from CSA
site_idMCSA1
Number of Residues
DetailsM-CSA 718
ChainResidueDetails

site_idMCSA2
Number of Residues
DetailsM-CSA 718
ChainResidueDetails

site_idMCSA3
Number of Residues
DetailsM-CSA 718
ChainResidueDetails

site_idMCSA4
Number of Residues
DetailsM-CSA 718
ChainResidueDetails

site_idMCSA5
Number of Residues
DetailsM-CSA 718
ChainResidueDetails

site_idMCSA6
Number of Residues
DetailsM-CSA 718
ChainResidueDetails

site_idMCSA7
Number of Residues
DetailsM-CSA 718
ChainResidueDetails

site_idMCSA8
Number of Residues
DetailsM-CSA 718
ChainResidueDetails

251174

PDB entries from 2026-03-25

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