9WXS
Silver-bound E.coli Malate dehydrogenase (C251S)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006096 | biological_process | glycolytic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006108 | biological_process | malate metabolic process |
| A | 0009061 | biological_process | anaerobic respiration |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016615 | molecular_function | malate dehydrogenase activity |
| A | 0019898 | cellular_component | extrinsic component of membrane |
| A | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006096 | biological_process | glycolytic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006108 | biological_process | malate metabolic process |
| B | 0009061 | biological_process | anaerobic respiration |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016615 | molecular_function | malate dehydrogenase activity |
| B | 0019898 | cellular_component | extrinsic component of membrane |
| B | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006096 | biological_process | glycolytic process |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0006108 | biological_process | malate metabolic process |
| C | 0009061 | biological_process | anaerobic respiration |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016615 | molecular_function | malate dehydrogenase activity |
| C | 0019898 | cellular_component | extrinsic component of membrane |
| C | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| C | 0042803 | molecular_function | protein homodimerization activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006096 | biological_process | glycolytic process |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0006108 | biological_process | malate metabolic process |
| D | 0009061 | biological_process | anaerobic respiration |
| D | 0016020 | cellular_component | membrane |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016615 | molecular_function | malate dehydrogenase activity |
| D | 0019898 | cellular_component | extrinsic component of membrane |
| D | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| D | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue AG A 401 |
| Chain | Residue |
| A | ASP71 |
| A | ALA112 |
| A | CYS113 |
| A | HOH608 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue AG B 401 |
| Chain | Residue |
| B | ASP71 |
| B | CYS113 |
| B | HOH634 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue AG C 401 |
| Chain | Residue |
| C | LEU242 |
| C | HOH626 |
| C | ASP71 |
| C | CYS113 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue AG D 401 |
| Chain | Residue |
| D | ASP71 |
| D | CYS113 |
| D | LEU242 |
| D | HOH598 |
Functional Information from PROSITE/UniProt
| site_id | PS00068 |
| Number of Residues | 13 |
| Details | MDH Malate dehydrogenase active site signature. VTTLDiiRSntfV |
| Chain | Residue | Details |
| A | VAL146-VAL158 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01516","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11389141","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01516","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11389141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8331658","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01516","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1507230","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8331658","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 527 |
| Chain | Residue | Details |
| A | ASP150 | modifies pKa |
| A | HIS177 | proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 527 |
| Chain | Residue | Details |
| B | ASP150 | modifies pKa |
| B | HIS177 | proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 2 |
| Details | M-CSA 527 |
| Chain | Residue | Details |
| C | ASP150 | modifies pKa |
| C | HIS177 | proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 2 |
| Details | M-CSA 527 |
| Chain | Residue | Details |
| D | ASP150 | modifies pKa |
| D | HIS177 | proton acceptor, proton donor |
