9WTD

Filament structure of human Reg3alpha

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0007157	biological_process	heterophilic cell-cell adhesion
A	0007165	biological_process	signal transduction
A	0008083	molecular_function	growth factor activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009609	biological_process	response to symbiotic bacterium
A	0009611	biological_process	response to wounding
A	0010838	biological_process	positive regulation of keratinocyte proliferation
A	0030246	molecular_function	carbohydrate binding
A	0042802	molecular_function	identical protein binding
A	0043434	biological_process	response to peptide hormone
A	0045617	biological_process	negative regulation of keratinocyte differentiation
A	0050728	biological_process	negative regulation of inflammatory response
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0090303	biological_process	positive regulation of wound healing
A	0106015	biological_process	negative regulation of inflammatory response to wounding
A	2000972	biological_process	positive regulation of detection of glucose
B	0005179	molecular_function	hormone activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0007157	biological_process	heterophilic cell-cell adhesion
B	0007165	biological_process	signal transduction
B	0008083	molecular_function	growth factor activity
B	0008284	biological_process	positive regulation of cell population proliferation
B	0009609	biological_process	response to symbiotic bacterium
B	0009611	biological_process	response to wounding
B	0010838	biological_process	positive regulation of keratinocyte proliferation
B	0030246	molecular_function	carbohydrate binding
B	0042802	molecular_function	identical protein binding
B	0043434	biological_process	response to peptide hormone
B	0045617	biological_process	negative regulation of keratinocyte differentiation
B	0050728	biological_process	negative regulation of inflammatory response
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0090303	biological_process	positive regulation of wound healing
B	0106015	biological_process	negative regulation of inflammatory response to wounding
B	2000972	biological_process	positive regulation of detection of glucose
C	0005179	molecular_function	hormone activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0007157	biological_process	heterophilic cell-cell adhesion
C	0007165	biological_process	signal transduction
C	0008083	molecular_function	growth factor activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009609	biological_process	response to symbiotic bacterium
C	0009611	biological_process	response to wounding
C	0010838	biological_process	positive regulation of keratinocyte proliferation
C	0030246	molecular_function	carbohydrate binding
C	0042802	molecular_function	identical protein binding
C	0043434	biological_process	response to peptide hormone
C	0045617	biological_process	negative regulation of keratinocyte differentiation
C	0050728	biological_process	negative regulation of inflammatory response
C	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
C	0090303	biological_process	positive regulation of wound healing
C	0106015	biological_process	negative regulation of inflammatory response to wounding
C	2000972	biological_process	positive regulation of detection of glucose
D	0005179	molecular_function	hormone activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0007157	biological_process	heterophilic cell-cell adhesion
D	0007165	biological_process	signal transduction
D	0008083	molecular_function	growth factor activity
D	0008284	biological_process	positive regulation of cell population proliferation
D	0009609	biological_process	response to symbiotic bacterium
D	0009611	biological_process	response to wounding
D	0010838	biological_process	positive regulation of keratinocyte proliferation
D	0030246	molecular_function	carbohydrate binding
D	0042802	molecular_function	identical protein binding
D	0043434	biological_process	response to peptide hormone
D	0045617	biological_process	negative regulation of keratinocyte differentiation
D	0050728	biological_process	negative regulation of inflammatory response
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0090303	biological_process	positive regulation of wound healing
D	0106015	biological_process	negative regulation of inflammatory response to wounding
D	2000972	biological_process	positive regulation of detection of glucose
E	0005179	molecular_function	hormone activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0007157	biological_process	heterophilic cell-cell adhesion
E	0007165	biological_process	signal transduction
E	0008083	molecular_function	growth factor activity
E	0008284	biological_process	positive regulation of cell population proliferation
E	0009609	biological_process	response to symbiotic bacterium
E	0009611	biological_process	response to wounding
E	0010838	biological_process	positive regulation of keratinocyte proliferation
E	0030246	molecular_function	carbohydrate binding
E	0042802	molecular_function	identical protein binding
E	0043434	biological_process	response to peptide hormone
E	0045617	biological_process	negative regulation of keratinocyte differentiation
E	0050728	biological_process	negative regulation of inflammatory response
E	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0090303	biological_process	positive regulation of wound healing
E	0106015	biological_process	negative regulation of inflammatory response to wounding
E	2000972	biological_process	positive regulation of detection of glucose
F	0005179	molecular_function	hormone activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0007157	biological_process	heterophilic cell-cell adhesion
F	0007165	biological_process	signal transduction
F	0008083	molecular_function	growth factor activity
F	0008284	biological_process	positive regulation of cell population proliferation
F	0009609	biological_process	response to symbiotic bacterium
F	0009611	biological_process	response to wounding
F	0010838	biological_process	positive regulation of keratinocyte proliferation
F	0030246	molecular_function	carbohydrate binding
F	0042802	molecular_function	identical protein binding
F	0043434	biological_process	response to peptide hormone
F	0045617	biological_process	negative regulation of keratinocyte differentiation
F	0050728	biological_process	negative regulation of inflammatory response
F	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
F	0090303	biological_process	positive regulation of wound healing
F	0106015	biological_process	negative regulation of inflammatory response to wounding
F	2000972	biological_process	positive regulation of detection of glucose
G	0005179	molecular_function	hormone activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0007157	biological_process	heterophilic cell-cell adhesion
G	0007165	biological_process	signal transduction
G	0008083	molecular_function	growth factor activity
G	0008284	biological_process	positive regulation of cell population proliferation
G	0009609	biological_process	response to symbiotic bacterium
G	0009611	biological_process	response to wounding
G	0010838	biological_process	positive regulation of keratinocyte proliferation
G	0030246	molecular_function	carbohydrate binding
G	0042802	molecular_function	identical protein binding
G	0043434	biological_process	response to peptide hormone
G	0045617	biological_process	negative regulation of keratinocyte differentiation
G	0050728	biological_process	negative regulation of inflammatory response
G	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
G	0090303	biological_process	positive regulation of wound healing
G	0106015	biological_process	negative regulation of inflammatory response to wounding
G	2000972	biological_process	positive regulation of detection of glucose
H	0005179	molecular_function	hormone activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0007157	biological_process	heterophilic cell-cell adhesion
H	0007165	biological_process	signal transduction
H	0008083	molecular_function	growth factor activity
H	0008284	biological_process	positive regulation of cell population proliferation
H	0009609	biological_process	response to symbiotic bacterium
H	0009611	biological_process	response to wounding
H	0010838	biological_process	positive regulation of keratinocyte proliferation
H	0030246	molecular_function	carbohydrate binding
H	0042802	molecular_function	identical protein binding
H	0043434	biological_process	response to peptide hormone
H	0045617	biological_process	negative regulation of keratinocyte differentiation
H	0050728	biological_process	negative regulation of inflammatory response
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
H	0090303	biological_process	positive regulation of wound healing
H	0106015	biological_process	negative regulation of inflammatory response to wounding
H	2000972	biological_process	positive regulation of detection of glucose
I	0005179	molecular_function	hormone activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005737	cellular_component	cytoplasm
I	0007157	biological_process	heterophilic cell-cell adhesion
I	0007165	biological_process	signal transduction
I	0008083	molecular_function	growth factor activity
I	0008284	biological_process	positive regulation of cell population proliferation
I	0009609	biological_process	response to symbiotic bacterium
I	0009611	biological_process	response to wounding
I	0010838	biological_process	positive regulation of keratinocyte proliferation
I	0030246	molecular_function	carbohydrate binding
I	0042802	molecular_function	identical protein binding
I	0043434	biological_process	response to peptide hormone
I	0045617	biological_process	negative regulation of keratinocyte differentiation
I	0050728	biological_process	negative regulation of inflammatory response
I	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
I	0090303	biological_process	positive regulation of wound healing
I	0106015	biological_process	negative regulation of inflammatory response to wounding
I	2000972	biological_process	positive regulation of detection of glucose
J	0005179	molecular_function	hormone activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005737	cellular_component	cytoplasm
J	0007157	biological_process	heterophilic cell-cell adhesion
J	0007165	biological_process	signal transduction
J	0008083	molecular_function	growth factor activity
J	0008284	biological_process	positive regulation of cell population proliferation
J	0009609	biological_process	response to symbiotic bacterium
J	0009611	biological_process	response to wounding
J	0010838	biological_process	positive regulation of keratinocyte proliferation
J	0030246	molecular_function	carbohydrate binding
J	0042802	molecular_function	identical protein binding
J	0043434	biological_process	response to peptide hormone
J	0045617	biological_process	negative regulation of keratinocyte differentiation
J	0050728	biological_process	negative regulation of inflammatory response
J	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
J	0090303	biological_process	positive regulation of wound healing
J	0106015	biological_process	negative regulation of inflammatory response to wounding
J	2000972	biological_process	positive regulation of detection of glucose
K	0005179	molecular_function	hormone activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005737	cellular_component	cytoplasm
K	0007157	biological_process	heterophilic cell-cell adhesion
K	0007165	biological_process	signal transduction
K	0008083	molecular_function	growth factor activity
K	0008284	biological_process	positive regulation of cell population proliferation
K	0009609	biological_process	response to symbiotic bacterium
K	0009611	biological_process	response to wounding
K	0010838	biological_process	positive regulation of keratinocyte proliferation
K	0030246	molecular_function	carbohydrate binding
K	0042802	molecular_function	identical protein binding
K	0043434	biological_process	response to peptide hormone
K	0045617	biological_process	negative regulation of keratinocyte differentiation
K	0050728	biological_process	negative regulation of inflammatory response
K	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
K	0090303	biological_process	positive regulation of wound healing
K	0106015	biological_process	negative regulation of inflammatory response to wounding
K	2000972	biological_process	positive regulation of detection of glucose
L	0005179	molecular_function	hormone activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005737	cellular_component	cytoplasm
L	0007157	biological_process	heterophilic cell-cell adhesion
L	0007165	biological_process	signal transduction
L	0008083	molecular_function	growth factor activity
L	0008284	biological_process	positive regulation of cell population proliferation
L	0009609	biological_process	response to symbiotic bacterium
L	0009611	biological_process	response to wounding
L	0010838	biological_process	positive regulation of keratinocyte proliferation
L	0030246	molecular_function	carbohydrate binding
L	0042802	molecular_function	identical protein binding
L	0043434	biological_process	response to peptide hormone
L	0045617	biological_process	negative regulation of keratinocyte differentiation
L	0050728	biological_process	negative regulation of inflammatory response
L	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
L	0090303	biological_process	positive regulation of wound healing
L	0106015	biological_process	negative regulation of inflammatory response to wounding
L	2000972	biological_process	positive regulation of detection of glucose

Functional Information from PROSITE/UniProt

site_id	PS00615
Number of Residues	26
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CAslsrstaflr..WKDYNCnvrlp.YVC

Chain	Residue	Details
A	CYS146-CYS171

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1500
Details	Domain: {"description":"C-type lectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00040","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	180
Details	Region: {"description":"Sufficient to activate EXTL3","evidences":[{"source":"PubMed","id":"19158046","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Motif: {"description":"EPN","evidences":[{"source":"PubMed","id":"20382864","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24256734","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MTH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---