9WSR
Structure of mouse NLRP14-KDM2A-SKP1 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003674 | molecular_function | molecular_function |
| A | 0005575 | cellular_component | cellular_component |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0007283 | biological_process | spermatogenesis |
| A | 0050727 | biological_process | regulation of inflammatory response |
| C | 0000209 | biological_process | protein polyubiquitination |
| C | 0000775 | cellular_component | chromosome, centromeric region |
| C | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005813 | cellular_component | centrosome |
| C | 0005829 | cellular_component | cytosol |
| C | 0005921 | cellular_component | gap junction |
| C | 0006338 | biological_process | chromatin remodeling |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| C | 0006513 | biological_process | protein monoubiquitination |
| C | 0006915 | biological_process | apoptotic process |
| C | 0007129 | biological_process | homologous chromosome pairing at meiosis |
| C | 0008013 | molecular_function | beta-catenin binding |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0019005 | cellular_component | SCF ubiquitin ligase complex |
| C | 0019904 | molecular_function | protein domain specific binding |
| C | 0031146 | biological_process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| C | 0031467 | cellular_component | Cul7-RING ubiquitin ligase complex |
| C | 0031519 | cellular_component | PcG protein complex |
| C | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| C | 0051457 | biological_process | maintenance of protein location in nucleus |
| C | 0070936 | biological_process | protein K48-linked ubiquitination |
| C | 0097602 | molecular_function | cullin family protein binding |
| C | 0140677 | molecular_function | molecular function activator activity |
| C | 0160072 | molecular_function | ubiquitin ligase complex scaffold activity |
| C | 1904037 | biological_process | positive regulation of epithelial cell apoptotic process |
| C | 1990444 | molecular_function | F-box domain binding |
| C | 1990756 | molecular_function | ubiquitin-like ligase-substrate adaptor activity |
| C | 1990757 | molecular_function | ubiquitin ligase activator activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"LRR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"LRR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 50 |
| Details | Repeat: {"description":"LRR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"LRR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"LRR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylarginine","evidences":[{"source":"PubMed","id":"32584788","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 59 |
| Details | Region: {"description":"Interaction with the F-box domain of F-box proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"UniProtKB","id":"P63208","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"LRR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"LRR 9"} |
| Chain | Residue | Details |
