9WQS

Crystal structure of Saccharomyces cerevisiae isoleucyl-tRNA synthetase in complex with reveromycin A and isoleucine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004822	molecular_function	isoleucine-tRNA ligase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006428	biological_process	isoleucyl-tRNA aminoacylation
A	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
A	1990825	molecular_function	sequence-specific mRNA binding

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	12
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PfaTGtPHYGHI

Chain	Residue	Details
A	PRO47-ILE58

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Motif: {"description":"'HIGH' region"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Motif: {"description":"'KMSKS' region"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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