9WDC
Cryo-EM structure of collagenase H (E416Q mutant) from Hathewaya histolytica bound to C-terminal region of the collagen-binding protein ColH (Pro-Pro-Gly)10
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005518 | molecular_function | collagen binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0032963 | biological_process | collagen metabolic process |
| A | 0034701 | molecular_function | tripeptidase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00216 |
| Number of Residues | 16 |
| Details | SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. MSFIMDEIGRRapqy..T |
| Chain | Residue | Details |
| A | MET53-THR68 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 81 |
| Details | Domain: {"description":"PKD 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00151","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 676 |
| Details | Region: {"description":"S1 metalloprotease domain","evidences":[{"source":"PubMed","id":"9452493","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9922257","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 279 |
| Details | Region: {"description":"Activator domain","evidences":[{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 271 |
| Details | Region: {"description":"Catalytic subdomain","evidences":[{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 112 |
| Details | Region: {"description":"Helper subdomain","evidences":[{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 92 |
| Details | Region: {"description":"S2a domain","evidences":[{"source":"PubMed","id":"9452493","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9922257","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9452493","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AR1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28820255","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AR1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ARF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28820255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10217773","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4AR1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ARF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23703618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28820255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10217773","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4AR1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ARF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25760606","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U7K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
