9W62
Cryo-EM structure of human ABCD3 in inward-facing conformation in the presence of phytanoyl-CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000038 | biological_process | very long-chain fatty acid metabolic process |
| B | 0005324 | molecular_function | long-chain fatty acid transmembrane transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005778 | cellular_component | peroxisomal membrane |
| B | 0005782 | cellular_component | peroxisomal matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0006635 | biological_process | fatty acid beta-oxidation |
| B | 0006699 | biological_process | bile acid biosynthetic process |
| B | 0006869 | biological_process | lipid transport |
| B | 0007031 | biological_process | peroxisome organization |
| B | 0008218 | biological_process | bioluminescence |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0015721 | biological_process | bile acid and bile salt transport |
| B | 0015910 | biological_process | long-chain fatty acid import into peroxisome |
| B | 0016020 | cellular_component | membrane |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| B | 0042760 | biological_process | very long-chain fatty acid catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| B | 0052817 | molecular_function | very long-chain fatty acyl-CoA hydrolase activity |
| B | 1903512 | biological_process | phytanic acid metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGEKQRMAMARLF |
| Chain | Residue | Details |
| B | LEU571-PHE585 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 287 |
| Details | Domain: {"description":"ABC transmembrane type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P55096","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
