9W4R
Cryo-EM structure of hTUT4_mini:hLin28A:pre-let-7g miRNA_UUU, conformation 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000932 | cellular_component | P-body |
| B | 0002151 | molecular_function | G-quadruplex RNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003729 | molecular_function | mRNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005791 | cellular_component | rough endoplasmic reticulum |
| B | 0005829 | cellular_component | cytosol |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0010494 | cellular_component | cytoplasmic stress granule |
| B | 0010587 | biological_process | miRNA catabolic process |
| B | 0010608 | biological_process | post-transcriptional regulation of gene expression |
| B | 0017148 | biological_process | negative regulation of translation |
| B | 0019827 | biological_process | stem cell population maintenance |
| B | 0031047 | biological_process | regulatory ncRNA-mediated gene silencing |
| B | 0031054 | biological_process | pre-miRNA processing |
| B | 0031123 | biological_process | RNA 3'-end processing |
| B | 0031369 | molecular_function | translation initiation factor binding |
| B | 0032008 | biological_process | positive regulation of TOR signaling |
| B | 0035198 | molecular_function | miRNA binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048863 | biological_process | stem cell differentiation |
| B | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| B | 0070883 | molecular_function | pre-miRNA binding |
| B | 0071333 | biological_process | cellular response to glucose stimulus |
| B | 0140517 | molecular_function | protein-RNA adaptor activity |
| B | 1901724 | biological_process | positive regulation of cell proliferation involved in kidney development |
| B | 1990825 | molecular_function | sequence-specific mRNA binding |
| B | 2000632 | biological_process | negative regulation of pre-miRNA processing |
| B | 2000767 | biological_process | positive regulation of cytoplasmic translation |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 23 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Ckl..ClihIeniqgahkHikekrH |
| Chain | Residue | Details |
| A | CYS306-HIS328 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 50 |
| Details | Domain: {"description":"PAP-associated 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 53 |
| Details | Domain: {"description":"PAP-associated 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 34 |
| Details | Zinc finger: {"description":"CCHC-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00047","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31036859","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q5VYS8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 73 |
| Details | Domain: {"description":"CSD"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 17 |
| Details | Zinc finger: {"description":"CCHC-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00047","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
