9W3Z
Cryo-EM structure of the 4:4 Lac1-Lip1 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006665 | biological_process | sphingolipid metabolic process |
| A | 0030148 | biological_process | sphingolipid biosynthetic process |
| A | 0034399 | cellular_component | nuclear periphery |
| A | 0046513 | biological_process | ceramide biosynthetic process |
| A | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| A | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005635 | cellular_component | nuclear envelope |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0030148 | biological_process | sphingolipid biosynthetic process |
| B | 0046513 | biological_process | ceramide biosynthetic process |
| B | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| B | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0005829 | cellular_component | cytosol |
| C | 0006665 | biological_process | sphingolipid metabolic process |
| C | 0030148 | biological_process | sphingolipid biosynthetic process |
| C | 0034399 | cellular_component | nuclear periphery |
| C | 0046513 | biological_process | ceramide biosynthetic process |
| C | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| C | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
| D | 0005515 | molecular_function | protein binding |
| D | 0005635 | cellular_component | nuclear envelope |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0005829 | cellular_component | cytosol |
| D | 0030148 | biological_process | sphingolipid biosynthetic process |
| D | 0046513 | biological_process | ceramide biosynthetic process |
| D | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| D | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
| E | 0005515 | molecular_function | protein binding |
| E | 0005783 | cellular_component | endoplasmic reticulum |
| E | 0005789 | cellular_component | endoplasmic reticulum membrane |
| E | 0005829 | cellular_component | cytosol |
| E | 0006665 | biological_process | sphingolipid metabolic process |
| E | 0030148 | biological_process | sphingolipid biosynthetic process |
| E | 0034399 | cellular_component | nuclear periphery |
| E | 0046513 | biological_process | ceramide biosynthetic process |
| E | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| E | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
| F | 0005515 | molecular_function | protein binding |
| F | 0005635 | cellular_component | nuclear envelope |
| F | 0005783 | cellular_component | endoplasmic reticulum |
| F | 0005789 | cellular_component | endoplasmic reticulum membrane |
| F | 0005829 | cellular_component | cytosol |
| F | 0030148 | biological_process | sphingolipid biosynthetic process |
| F | 0046513 | biological_process | ceramide biosynthetic process |
| F | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| F | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
| G | 0005515 | molecular_function | protein binding |
| G | 0005783 | cellular_component | endoplasmic reticulum |
| G | 0005789 | cellular_component | endoplasmic reticulum membrane |
| G | 0005829 | cellular_component | cytosol |
| G | 0006665 | biological_process | sphingolipid metabolic process |
| G | 0030148 | biological_process | sphingolipid biosynthetic process |
| G | 0034399 | cellular_component | nuclear periphery |
| G | 0046513 | biological_process | ceramide biosynthetic process |
| G | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| G | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
| H | 0005515 | molecular_function | protein binding |
| H | 0005635 | cellular_component | nuclear envelope |
| H | 0005783 | cellular_component | endoplasmic reticulum |
| H | 0005789 | cellular_component | endoplasmic reticulum membrane |
| H | 0005829 | cellular_component | cytosol |
| H | 0030148 | biological_process | sphingolipid biosynthetic process |
| H | 0046513 | biological_process | ceramide biosynthetic process |
| H | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| H | 0061576 | cellular_component | acyl-CoA ceramide synthase complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 728 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"37953642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 284 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"37953642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 100 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37953642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 868 |
| Details | Domain: {"description":"TLC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00205","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Y2M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 100 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37953642","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IZD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QTR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Y2M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39528796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QTN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 76 |
| Details | Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 436 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"15692566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964337","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
