9VXW
Cryo-EM structure of hAQP11 in LMNG
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006612 | biological_process | protein targeting to membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006833 | biological_process | water transport |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0009101 | biological_process | glycoprotein biosynthetic process |
| A | 0009986 | cellular_component | cell surface |
| A | 0009992 | biological_process | intracellular water homeostasis |
| A | 0015250 | molecular_function | water channel activity |
| A | 0015254 | molecular_function | glycerol channel activity |
| A | 0015793 | biological_process | glycerol transmembrane transport |
| A | 0015840 | biological_process | urea transport |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0032364 | biological_process | intracellular oxygen homeostasis |
| A | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0072014 | biological_process | proximal tubule development |
| A | 0080170 | biological_process | hydrogen peroxide transmembrane transport |
| A | 0140070 | molecular_function | hydrogen peroxide channel activity |
| A | 1903573 | biological_process | negative regulation of response to endoplasmic reticulum stress |
| A | 1904293 | biological_process | negative regulation of ERAD pathway |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 90 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"31546170","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"31546170","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Motif: {"description":"NPC","evidences":[{"source":"UniProtKB","id":"Q96PS8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Motif: {"description":"NPA","evidences":[{"source":"UniProtKB","id":"Q96PS8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
