9VVJ

Cryo-EM structure of the erlin1/2 complex purified using DDM and GDN

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005515	molecular_function	protein binding
a	0005783	cellular_component	endoplasmic reticulum
a	0005789	cellular_component	endoplasmic reticulum membrane
a	0005886	cellular_component	plasma membrane
a	0015485	molecular_function	cholesterol binding
a	0031625	molecular_function	ubiquitin protein ligase binding
a	0032933	biological_process	SREBP signaling pathway
a	0032991	cellular_component	protein-containing complex
a	0036503	biological_process	ERAD pathway
a	0045121	cellular_component	membrane raft
a	0045540	biological_process	regulation of cholesterol biosynthetic process
a	0045541	biological_process	negative regulation of cholesterol biosynthetic process
a	0045717	biological_process	negative regulation of fatty acid biosynthetic process
b	0005515	molecular_function	protein binding
b	0005783	cellular_component	endoplasmic reticulum
b	0005789	cellular_component	endoplasmic reticulum membrane
b	0005886	cellular_component	plasma membrane
b	0015485	molecular_function	cholesterol binding
b	0031625	molecular_function	ubiquitin protein ligase binding
b	0032933	biological_process	SREBP signaling pathway
b	0032991	cellular_component	protein-containing complex
b	0036503	biological_process	ERAD pathway
b	0045121	cellular_component	membrane raft
b	0045540	biological_process	regulation of cholesterol biosynthetic process
b	0045541	biological_process	negative regulation of cholesterol biosynthetic process
b	0045717	biological_process	negative regulation of fatty acid biosynthetic process
c	0005515	molecular_function	protein binding
c	0005783	cellular_component	endoplasmic reticulum
c	0005789	cellular_component	endoplasmic reticulum membrane
c	0005886	cellular_component	plasma membrane
c	0015485	molecular_function	cholesterol binding
c	0031625	molecular_function	ubiquitin protein ligase binding
c	0032933	biological_process	SREBP signaling pathway
c	0032991	cellular_component	protein-containing complex
c	0036503	biological_process	ERAD pathway
c	0045121	cellular_component	membrane raft
c	0045540	biological_process	regulation of cholesterol biosynthetic process
c	0045541	biological_process	negative regulation of cholesterol biosynthetic process
c	0045717	biological_process	negative regulation of fatty acid biosynthetic process
d	0005515	molecular_function	protein binding
d	0005783	cellular_component	endoplasmic reticulum
d	0005789	cellular_component	endoplasmic reticulum membrane
d	0005886	cellular_component	plasma membrane
d	0015485	molecular_function	cholesterol binding
d	0031625	molecular_function	ubiquitin protein ligase binding
d	0032933	biological_process	SREBP signaling pathway
d	0032991	cellular_component	protein-containing complex
d	0036503	biological_process	ERAD pathway
d	0045121	cellular_component	membrane raft
d	0045540	biological_process	regulation of cholesterol biosynthetic process
d	0045541	biological_process	negative regulation of cholesterol biosynthetic process
d	0045717	biological_process	negative regulation of fatty acid biosynthetic process
e	0005515	molecular_function	protein binding
e	0005783	cellular_component	endoplasmic reticulum
e	0005789	cellular_component	endoplasmic reticulum membrane
e	0005886	cellular_component	plasma membrane
e	0015485	molecular_function	cholesterol binding
e	0031625	molecular_function	ubiquitin protein ligase binding
e	0032933	biological_process	SREBP signaling pathway
e	0032991	cellular_component	protein-containing complex
e	0036503	biological_process	ERAD pathway
e	0045121	cellular_component	membrane raft
e	0045540	biological_process	regulation of cholesterol biosynthetic process
e	0045541	biological_process	negative regulation of cholesterol biosynthetic process
e	0045717	biological_process	negative regulation of fatty acid biosynthetic process
f	0005515	molecular_function	protein binding
f	0005783	cellular_component	endoplasmic reticulum
f	0005789	cellular_component	endoplasmic reticulum membrane
f	0005886	cellular_component	plasma membrane
f	0015485	molecular_function	cholesterol binding
f	0031625	molecular_function	ubiquitin protein ligase binding
f	0032933	biological_process	SREBP signaling pathway
f	0032991	cellular_component	protein-containing complex
f	0036503	biological_process	ERAD pathway
f	0045121	cellular_component	membrane raft
f	0045540	biological_process	regulation of cholesterol biosynthetic process
f	0045541	biological_process	negative regulation of cholesterol biosynthetic process
f	0045717	biological_process	negative regulation of fatty acid biosynthetic process
g	0005515	molecular_function	protein binding
g	0005783	cellular_component	endoplasmic reticulum
g	0005789	cellular_component	endoplasmic reticulum membrane
g	0005886	cellular_component	plasma membrane
g	0015485	molecular_function	cholesterol binding
g	0031625	molecular_function	ubiquitin protein ligase binding
g	0032933	biological_process	SREBP signaling pathway
g	0032991	cellular_component	protein-containing complex
g	0036503	biological_process	ERAD pathway
g	0045121	cellular_component	membrane raft
g	0045540	biological_process	regulation of cholesterol biosynthetic process
g	0045541	biological_process	negative regulation of cholesterol biosynthetic process
g	0045717	biological_process	negative regulation of fatty acid biosynthetic process
h	0005515	molecular_function	protein binding
h	0005783	cellular_component	endoplasmic reticulum
h	0005789	cellular_component	endoplasmic reticulum membrane
h	0005886	cellular_component	plasma membrane
h	0015485	molecular_function	cholesterol binding
h	0031625	molecular_function	ubiquitin protein ligase binding
h	0032933	biological_process	SREBP signaling pathway
h	0032991	cellular_component	protein-containing complex
h	0036503	biological_process	ERAD pathway
h	0045121	cellular_component	membrane raft
h	0045540	biological_process	regulation of cholesterol biosynthetic process
h	0045541	biological_process	negative regulation of cholesterol biosynthetic process
h	0045717	biological_process	negative regulation of fatty acid biosynthetic process
i	0005515	molecular_function	protein binding
i	0005783	cellular_component	endoplasmic reticulum
i	0005789	cellular_component	endoplasmic reticulum membrane
i	0005886	cellular_component	plasma membrane
i	0015485	molecular_function	cholesterol binding
i	0031625	molecular_function	ubiquitin protein ligase binding
i	0032933	biological_process	SREBP signaling pathway
i	0032991	cellular_component	protein-containing complex
i	0036503	biological_process	ERAD pathway
i	0045121	cellular_component	membrane raft
i	0045540	biological_process	regulation of cholesterol biosynthetic process
i	0045541	biological_process	negative regulation of cholesterol biosynthetic process
i	0045717	biological_process	negative regulation of fatty acid biosynthetic process
j	0005515	molecular_function	protein binding
j	0005783	cellular_component	endoplasmic reticulum
j	0005789	cellular_component	endoplasmic reticulum membrane
j	0005886	cellular_component	plasma membrane
j	0015485	molecular_function	cholesterol binding
j	0031625	molecular_function	ubiquitin protein ligase binding
j	0032933	biological_process	SREBP signaling pathway
j	0032991	cellular_component	protein-containing complex
j	0036503	biological_process	ERAD pathway
j	0045121	cellular_component	membrane raft
j	0045540	biological_process	regulation of cholesterol biosynthetic process
j	0045541	biological_process	negative regulation of cholesterol biosynthetic process
j	0045717	biological_process	negative regulation of fatty acid biosynthetic process
k	0005515	molecular_function	protein binding
k	0005783	cellular_component	endoplasmic reticulum
k	0005789	cellular_component	endoplasmic reticulum membrane
k	0005886	cellular_component	plasma membrane
k	0015485	molecular_function	cholesterol binding
k	0031625	molecular_function	ubiquitin protein ligase binding
k	0032933	biological_process	SREBP signaling pathway
k	0032991	cellular_component	protein-containing complex
k	0036503	biological_process	ERAD pathway
k	0045121	cellular_component	membrane raft
k	0045540	biological_process	regulation of cholesterol biosynthetic process
k	0045541	biological_process	negative regulation of cholesterol biosynthetic process
k	0045717	biological_process	negative regulation of fatty acid biosynthetic process
l	0005515	molecular_function	protein binding
l	0005783	cellular_component	endoplasmic reticulum
l	0005789	cellular_component	endoplasmic reticulum membrane
l	0005886	cellular_component	plasma membrane
l	0015485	molecular_function	cholesterol binding
l	0031625	molecular_function	ubiquitin protein ligase binding
l	0032933	biological_process	SREBP signaling pathway
l	0032991	cellular_component	protein-containing complex
l	0036503	biological_process	ERAD pathway
l	0045121	cellular_component	membrane raft
l	0045540	biological_process	regulation of cholesterol biosynthetic process
l	0045541	biological_process	negative regulation of cholesterol biosynthetic process
l	0045717	biological_process	negative regulation of fatty acid biosynthetic process
m	0005515	molecular_function	protein binding
m	0005783	cellular_component	endoplasmic reticulum
m	0005789	cellular_component	endoplasmic reticulum membrane
m	0005886	cellular_component	plasma membrane
m	0015485	molecular_function	cholesterol binding
m	0031625	molecular_function	ubiquitin protein ligase binding
m	0032933	biological_process	SREBP signaling pathway
m	0032991	cellular_component	protein-containing complex
m	0036503	biological_process	ERAD pathway
m	0045121	cellular_component	membrane raft
m	0045540	biological_process	regulation of cholesterol biosynthetic process
m	0045541	biological_process	negative regulation of cholesterol biosynthetic process
m	0045717	biological_process	negative regulation of fatty acid biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	520
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	13
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	13
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	13
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O75477","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	13
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17502376","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---