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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9VSQ

The TUG-891-bound structure of TMEM175

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=TM1-1","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=TM2-1","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues104
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=TM3-1","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues108
DetailsTopological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=TM4-1","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=TM5-1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=TM1-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=TM2-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=TM3-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=TM4-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=TM5-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues52
DetailsTransmembrane: {"description":"Helical; Name=TM6-2","evidences":[{"source":"PubMed","id":"32228865","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WC9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WCC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues16
DetailsRegion: {"description":"Short helix H1-2","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues12
DetailsRegion: {"description":"Short helix H2-2","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues12
DetailsMotif: {"description":"RxxxFSD motif 1","evidences":[{"source":"PubMed","id":"26317472","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues12
DetailsMotif: {"description":"RxxxFSD motif 2","evidences":[{"source":"PubMed","id":"26317472","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsSite: {"description":"Hydrophobic filter residue 1-1","evidences":[{"source":"PubMed","id":"28723891","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsSite: {"description":"Hydrophobic filter residue 2-1","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsSite: {"description":"Hydrophobic filter residue 3-1","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsSite: {"description":"Hydrophobic filter residue 1-2","evidences":[{"source":"PubMed","id":"28723891","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsSite: {"description":"Hydrophobic filter residue 2-2","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsSite: {"description":"Hydrophobic filter residue 3-2","evidences":[{"source":"UniProtKB","id":"K9UJK2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-11-05

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