9VPV

Crystal structure of the C131A mutant of Trypanosoma brucei DHODH in FMN-oxidized, orotate-bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004152	molecular_function	dihydroorotate dehydrogenase activity
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006106	biological_process	fumarate metabolic process
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0020015	cellular_component	glycosome
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0097014	cellular_component	ciliary plasm
A	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity
B	0004152	molecular_function	dihydroorotate dehydrogenase activity
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006106	biological_process	fumarate metabolic process
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0020015	cellular_component	glycosome
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0097014	cellular_component	ciliary plasm
B	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity
C	0004152	molecular_function	dihydroorotate dehydrogenase activity
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0006106	biological_process	fumarate metabolic process
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0020015	cellular_component	glycosome
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0097014	cellular_component	ciliary plasm
C	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity
D	0004152	molecular_function	dihydroorotate dehydrogenase activity
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0006106	biological_process	fumarate metabolic process
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0020015	cellular_component	glycosome
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0097014	cellular_component	ciliary plasm
D	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18312275","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	28
Details	Binding site: {}

Chain

Residue

Details

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