9VCA

Binding site between C-reactive protein and c2cc monoclonal antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0001849	molecular_function	complement component C1q complex binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006953	biological_process	acute-phase response
E	0006954	biological_process	inflammatory response
E	0008228	biological_process	opsonization
E	0010628	biological_process	positive regulation of gene expression
E	0010745	biological_process	negative regulation of macrophage derived foam cell differentiation
E	0010888	biological_process	negative regulation of lipid storage
E	0030169	molecular_function	low-density lipoprotein particle binding
E	0032677	biological_process	regulation of interleukin-8 production
E	0032930	biological_process	positive regulation of superoxide anion generation
E	0032945	biological_process	negative regulation of mononuclear cell proliferation
E	0033265	molecular_function	choline binding
E	0042310	biological_process	vasoconstriction
E	0042802	molecular_function	identical protein binding
E	0045087	biological_process	innate immune response
E	0046790	molecular_function	virion binding
E	0046872	molecular_function	metal ion binding
E	0050750	molecular_function	low-density lipoprotein particle receptor binding
E	0050830	biological_process	defense response to Gram-positive bacterium

Functional Information from PROSITE/UniProt

site_id	PS00289
Number of Residues	8
Details	PTX_1 Pentraxin domain signature. HiCtSWeS

Chain	Residue	Details
E	HIS95-SER102

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR196-HIS202

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	201
Details	Domain: {"description":"Pentraxin (PTX)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01172","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01172","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"762075","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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