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9V43

Cryo-EM structure of DICER/26S-UG complex in dicing state

Functional Information from GO Data
ChainGOidnamespacecontents
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0003723molecular_functionRNA binding
B0003725molecular_functiondouble-stranded RNA binding
B0004521molecular_functionRNA endonuclease activity
B0004525molecular_functionribonuclease III activity
B0004530molecular_functiondeoxyribonuclease I activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006309biological_processapoptotic DNA fragmentation
B0010586biological_processmiRNA metabolic process
B0010626biological_processnegative regulation of Schwann cell proliferation
B0010629biological_processnegative regulation of gene expression
B0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
B0014040biological_processpositive regulation of Schwann cell differentiation
B0016078biological_processtRNA decay
B0016441biological_processpost-transcriptional gene silencing
B0016442cellular_componentRISC complex
B0019904molecular_functionprotein domain specific binding
B0021675biological_processnerve development
B0030422biological_processsiRNA processing
B0031054biological_processpre-miRNA processing
B0031643biological_processpositive regulation of myelination
B0032290biological_processperipheral nervous system myelin formation
B0032720biological_processnegative regulation of tumor necrosis factor production
B0035196biological_processmiRNA processing
B0035197molecular_functionsiRNA binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048812biological_processneuron projection morphogenesis
B0051239biological_processregulation of multicellular organismal process
B0061980molecular_functionregulatory RNA binding
B0070062cellular_componentextracellular exosome
B0070578cellular_componentRISC-loading complex
B0070883molecular_functionpre-miRNA binding
B0070922biological_processRISC complex assembly
B0098795biological_processglobal gene silencing by mRNA cleavage
Functional Information from PROSITE/UniProt
site_idPS00517
Number of Residues9
DetailsRNASE_3_1 Ribonuclease III family signature. QRLEFLGDA
ChainResidueDetails
BGLN1702-ALA1710

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues147
DetailsDomain: {"description":"PAZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00142","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17920623","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EB1","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsSite: {"description":"Important for activity","evidences":[{"source":"UniProtKB","id":"Q8R418","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

254227

PDB entries from 2026-05-27

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