9V42

Cryo-EM structure of DICER/26S-GU complex in dicing state

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0003723	molecular_function	RNA binding
D	0003725	molecular_function	double-stranded RNA binding
D	0004521	molecular_function	RNA endonuclease activity
D	0004525	molecular_function	ribonuclease III activity
D	0004530	molecular_function	deoxyribonuclease I activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006309	biological_process	apoptotic DNA fragmentation
D	0010586	biological_process	miRNA metabolic process
D	0010626	biological_process	negative regulation of Schwann cell proliferation
D	0010629	biological_process	negative regulation of gene expression
D	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
D	0014040	biological_process	positive regulation of Schwann cell differentiation
D	0016078	biological_process	tRNA decay
D	0016441	biological_process	post-transcriptional gene silencing
D	0016442	cellular_component	RISC complex
D	0019904	molecular_function	protein domain specific binding
D	0021675	biological_process	nerve development
D	0030422	biological_process	siRNA processing
D	0031054	biological_process	pre-miRNA processing
D	0031643	biological_process	positive regulation of myelination
D	0032290	biological_process	peripheral nervous system myelin formation
D	0032720	biological_process	negative regulation of tumor necrosis factor production
D	0035196	biological_process	miRNA processing
D	0035197	molecular_function	siRNA binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0048812	biological_process	neuron projection morphogenesis
D	0051239	biological_process	regulation of multicellular organismal process
D	0061980	molecular_function	regulatory RNA binding
D	0070062	cellular_component	extracellular exosome
D	0070578	cellular_component	RISC-loading complex
D	0070883	molecular_function	pre-miRNA binding
D	0070922	biological_process	RISC complex assembly
D	0098795	biological_process	global gene silencing by mRNA cleavage

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	147
Details	Domain: {"description":"PAZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00142","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17920623","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EB1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Important for activity","evidences":[{"source":"UniProtKB","id":"Q8R418","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---