9V13

Crystal structure of ACAT2 in complex with ZH-2-077

This is a non-PDB format compatible entry.

Functional Information from PROSITE/UniProt

site_id	PS00099
Number of Residues	14
Details	THIOLASE_3 Thiolases active site. GVAALCIGgGmGiA

Chain	Residue	Details
A	GLY378-ALA391

---

site_id	PS00737
Number of Residues	17
Details	THIOLASE_2 Thiolases signature 2. NieGGaIAlGHPlGaSG

Chain	Residue	Details
A	ASN343-GLY359

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Acyl-thioester intermediate","evidences":[{"source":"PubMed","id":"15733928","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"15733928","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15733928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WL4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Increases nucleophilicity of active site Cys","evidences":[{"source":"UniProtKB","id":"P42765","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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