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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9UXX

SalA bound Kappa Opioid Receptor homodimer

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
a0001750cellular_componentphotoreceptor outer segment
a0001917cellular_componentphotoreceptor inner segment
a0003924molecular_functionGTPase activity
a0005515molecular_functionprotein binding
a0005737cellular_componentcytoplasm
a0005834cellular_componentheterotrimeric G-protein complex
a0005886cellular_componentplasma membrane
a0007186biological_processG protein-coupled receptor signaling pathway
a0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
a0007204biological_processpositive regulation of cytosolic calcium ion concentration
a0008283biological_processcell population proliferation
a0010659biological_processcardiac muscle cell apoptotic process
a0030159molecular_functionsignaling receptor complex adaptor activity
a0030425cellular_componentdendrite
a0030507molecular_functionspectrin binding
a0042622cellular_componentphotoreceptor outer segment membrane
a0044297cellular_componentcell body
a0044877molecular_functionprotein-containing complex binding
a0045202cellular_componentsynapse
a0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
a0050909biological_processsensory perception of taste
a0051020molecular_functionGTPase binding
a0060041biological_processretina development in camera-type eye
a0071456biological_processcellular response to hypoxia
A0001750cellular_componentphotoreceptor outer segment
A0001917cellular_componentphotoreceptor inner segment
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007186biological_processG protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0008283biological_processcell population proliferation
A0010659biological_processcardiac muscle cell apoptotic process
A0030159molecular_functionsignaling receptor complex adaptor activity
A0030425cellular_componentdendrite
A0030507molecular_functionspectrin binding
A0042622cellular_componentphotoreceptor outer segment membrane
A0044297cellular_componentcell body
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
A0050909biological_processsensory perception of taste
A0051020molecular_functionGTPase binding
A0060041biological_processretina development in camera-type eye
A0071456biological_processcellular response to hypoxia
b0000132biological_processestablishment of mitotic spindle orientation
b0000287molecular_functionmagnesium ion binding
b0000922cellular_componentspindle pole
b0001664molecular_functionG protein-coupled receptor binding
b0003924molecular_functionGTPase activity
b0003925molecular_functionG protein activity
b0005515molecular_functionprotein binding
b0005525molecular_functionGTP binding
b0005634cellular_componentnucleus
b0005737cellular_componentcytoplasm
b0005765cellular_componentlysosomal membrane
b0005813cellular_componentcentrosome
b0005829cellular_componentcytosol
b0005834cellular_componentheterotrimeric G-protein complex
b0005886cellular_componentplasma membrane
b0005938cellular_componentcell cortex
b0007186biological_processG protein-coupled receptor signaling pathway
b0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
b0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
b0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
b0007195biological_processadenylate cyclase-inhibiting dopamine receptor signaling pathway
b0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
b0007218biological_processneuropeptide signaling pathway
b0008277biological_processregulation of G protein-coupled receptor signaling pathway
b0009898cellular_componentcytoplasmic side of plasma membrane
b0010855molecular_functionadenylate cyclase inhibitor activity
b0016020cellular_componentmembrane
b0019003molecular_functionGDP binding
b0030496cellular_componentmidbody
b0031749molecular_functionD2 dopamine receptor binding
b0031821molecular_functionG protein-coupled serotonin receptor binding
b0034695biological_processresponse to prostaglandin E
b0038112biological_processinterleukin-8-mediated signaling pathway
b0043303biological_processmast cell degranulation
b0043434biological_processresponse to peptide hormone
b0045542biological_processpositive regulation of cholesterol biosynthetic process
b0046888biological_processnegative regulation of hormone secretion
b0051301biological_processcell division
b0060236biological_processregulation of mitotic spindle organization
b0070062cellular_componentextracellular exosome
b0070098biological_processchemokine-mediated signaling pathway
b0072678biological_processT cell migration
b1901082biological_processpositive regulation of relaxation of smooth muscle
b1903998biological_processregulation of eating behavior
b1904322biological_processcellular response to forskolin
b1904778biological_processpositive regulation of protein localization to cell cortex
B0000132biological_processestablishment of mitotic spindle orientation
B0000287molecular_functionmagnesium ion binding
B0000922cellular_componentspindle pole
B0001664molecular_functionG protein-coupled receptor binding
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0007186biological_processG protein-coupled receptor signaling pathway
B0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0007195biological_processadenylate cyclase-inhibiting dopamine receptor signaling pathway
B0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
B0007218biological_processneuropeptide signaling pathway
B0008277biological_processregulation of G protein-coupled receptor signaling pathway
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010855molecular_functionadenylate cyclase inhibitor activity
B0016020cellular_componentmembrane
B0019003molecular_functionGDP binding
B0030496cellular_componentmidbody
B0031749molecular_functionD2 dopamine receptor binding
B0031821molecular_functionG protein-coupled serotonin receptor binding
B0034695biological_processresponse to prostaglandin E
B0038112biological_processinterleukin-8-mediated signaling pathway
B0043303biological_processmast cell degranulation
B0043434biological_processresponse to peptide hormone
B0045542biological_processpositive regulation of cholesterol biosynthetic process
B0046888biological_processnegative regulation of hormone secretion
B0051301biological_processcell division
B0060236biological_processregulation of mitotic spindle organization
B0070062cellular_componentextracellular exosome
B0070098biological_processchemokine-mediated signaling pathway
B0072678biological_processT cell migration
B1901082biological_processpositive regulation of relaxation of smooth muscle
B1903998biological_processregulation of eating behavior
B1904322biological_processcellular response to forskolin
B1904778biological_processpositive regulation of protein localization to cell cortex
d0003925molecular_functionG protein activity
d0005515molecular_functionprotein binding
d0005834cellular_componentheterotrimeric G-protein complex
d0005886cellular_componentplasma membrane
d0007186biological_processG protein-coupled receptor signaling pathway
d0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
d0016020cellular_componentmembrane
d0031681molecular_functionG-protein beta-subunit binding
d0070062cellular_componentextracellular exosome
d0071380biological_processcellular response to prostaglandin E stimulus
d0071870biological_processcellular response to catecholamine stimulus
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0031681molecular_functionG-protein beta-subunit binding
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
r0004985molecular_functionG protein-coupled opioid receptor activity
r0005515molecular_functionprotein binding
r0005739cellular_componentmitochondrion
r0005886cellular_componentplasma membrane
r0006955biological_processimmune response
r0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
r0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
r0007218biological_processneuropeptide signaling pathway
r0007268biological_processchemical synaptic transmission
r0007600biological_processsensory perception
r0007626biological_processlocomotory behavior
r0008528molecular_functionG protein-coupled peptide receptor activity
r0016020cellular_componentmembrane
r0016529cellular_componentsarcoplasmic reticulum
r0019233biological_processsensory perception of pain
r0030315cellular_componentT-tubule
r0030425cellular_componentdendrite
r0031635biological_processadenylate cyclase-inhibiting opioid receptor signaling pathway
r0032868biological_processresponse to insulin
r0033603biological_processpositive regulation of dopamine secretion
r0033612molecular_functionreceptor serine/threonine kinase binding
r0033685biological_processnegative regulation of luteinizing hormone secretion
r0035094biological_processresponse to nicotine
r0038003biological_processG protein-coupled opioid receptor signaling pathway
r0038048molecular_functiondynorphin receptor activity
r0042220biological_processresponse to cocaine
r0042383cellular_componentsarcolemma
r0042711biological_processmaternal behavior
r0042755biological_processeating behavior
r0042923molecular_functionneuropeptide binding
r0043005cellular_componentneuron projection
r0043025cellular_componentneuronal cell body
r0043204cellular_componentperikaryon
r0043627biological_processresponse to estrogen
r0043679cellular_componentaxon terminus
r0044849biological_processestrous cycle
r0045471biological_processresponse to ethanol
r0046877biological_processregulation of saliva secretion
r0048148biological_processbehavioral response to cocaine
r0050951biological_processsensory perception of temperature stimulus
r0051607biological_processdefense response to virus
r0071222biological_processcellular response to lipopolysaccharide
r0071333biological_processcellular response to glucose stimulus
r1900745biological_processpositive regulation of p38MAPK cascade
r1901381biological_processpositive regulation of potassium ion transmembrane transport
r1903937biological_processresponse to acrylamide
r1904000biological_processpositive regulation of eating behavior
r1990708biological_processconditioned place preference
R0004985molecular_functionG protein-coupled opioid receptor activity
R0005515molecular_functionprotein binding
R0005739cellular_componentmitochondrion
R0005886cellular_componentplasma membrane
R0006955biological_processimmune response
R0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007218biological_processneuropeptide signaling pathway
R0007268biological_processchemical synaptic transmission
R0007600biological_processsensory perception
R0007626biological_processlocomotory behavior
R0008528molecular_functionG protein-coupled peptide receptor activity
R0016020cellular_componentmembrane
R0016529cellular_componentsarcoplasmic reticulum
R0019233biological_processsensory perception of pain
R0030315cellular_componentT-tubule
R0030425cellular_componentdendrite
R0031635biological_processadenylate cyclase-inhibiting opioid receptor signaling pathway
R0032868biological_processresponse to insulin
R0033603biological_processpositive regulation of dopamine secretion
R0033612molecular_functionreceptor serine/threonine kinase binding
R0033685biological_processnegative regulation of luteinizing hormone secretion
R0035094biological_processresponse to nicotine
R0038003biological_processG protein-coupled opioid receptor signaling pathway
R0038048molecular_functiondynorphin receptor activity
R0042220biological_processresponse to cocaine
R0042383cellular_componentsarcolemma
R0042711biological_processmaternal behavior
R0042755biological_processeating behavior
R0042923molecular_functionneuropeptide binding
R0043005cellular_componentneuron projection
R0043025cellular_componentneuronal cell body
R0043204cellular_componentperikaryon
R0043627biological_processresponse to estrogen
R0043679cellular_componentaxon terminus
R0044849biological_processestrous cycle
R0045471biological_processresponse to ethanol
R0046877biological_processregulation of saliva secretion
R0048148biological_processbehavioral response to cocaine
R0050951biological_processsensory perception of temperature stimulus
R0051607biological_processdefense response to virus
R0071222biological_processcellular response to lipopolysaccharide
R0071333biological_processcellular response to glucose stimulus
R1900745biological_processpositive regulation of p38MAPK cascade
R1901381biological_processpositive regulation of potassium ion transmembrane transport
R1903937biological_processresponse to acrylamide
R1904000biological_processpositive regulation of eating behavior
R1990708biological_processconditioned place preference
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLTMMSVDRYIaV
ChainResidueDetails
RTHR144-VAL160
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
ALEU70-SER84
AILE157-ILE171
ALEU285-ALA299
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues96
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues90
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues82
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues86
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues82
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues60
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=1"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues106
DetailsTopological domain: {"description":"Cytoplasmic"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=2"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues102
DetailsTopological domain: {"description":"Extracellular"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=3"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=4"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=5"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=6"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=7"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues26
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues18
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues14
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues10
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21115486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ONW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5Q","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18434541","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22383884","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21115486","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PDB","id":"1Y3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ONW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5Q","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues2
DetailsModified residue: {"description":"Deamidated glutamine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues2
DetailsModified residue: {"description":"ADP-ribosylcysteine; by pertussis toxin","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsLipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"PubMed","id":"20213681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P10824","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2026-07-22

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