Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9UXC

The ADP-bound structure of BCL7B-containing ARP module of the human SWI/SNF complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000776	cellular_component	kinetochore
B	0000785	cellular_component	chromatin
B	0000786	cellular_component	nucleosome
B	0000930	cellular_component	gamma-tubulin complex
B	0001738	biological_process	morphogenesis of a polarized epithelium
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005884	cellular_component	actin filament
B	0005886	cellular_component	plasma membrane
B	0005903	cellular_component	brush border
B	0005911	cellular_component	cell-cell junction
B	0005912	cellular_component	adherens junction
B	0005925	cellular_component	focal adhesion
B	0006338	biological_process	chromatin remodeling
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0007010	biological_process	cytoskeleton organization
B	0007020	biological_process	microtubule nucleation
B	0007163	biological_process	establishment or maintenance of cell polarity
B	0007409	biological_process	axonogenesis
B	0008284	biological_process	positive regulation of cell population proliferation
B	0015629	cellular_component	actin cytoskeleton
B	0016020	cellular_component	membrane
B	0016363	cellular_component	nuclear matrix
B	0016514	cellular_component	SWI/SNF complex
B	0016586	cellular_component	RSC-type complex
B	0016887	molecular_function	ATP hydrolysis activity
B	0019894	molecular_function	kinesin binding
B	0019901	molecular_function	protein kinase binding
B	0021762	biological_process	substantia nigra development
B	0030027	cellular_component	lamellipodium
B	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
B	0030235	molecular_function	nitric-oxide synthase regulator activity
B	0030424	cellular_component	axon
B	0030863	cellular_component	cortical cytoskeleton
B	0030957	molecular_function	Tat protein binding
B	0031492	molecular_function	nucleosomal DNA binding
B	0031982	cellular_component	vesicle
B	0032991	cellular_component	protein-containing complex
B	0034333	biological_process	adherens junction assembly
B	0035060	cellular_component	brahma complex
B	0035267	cellular_component	NuA4 histone acetyltransferase complex
B	0035633	biological_process	maintenance of blood-brain barrier
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0042802	molecular_function	identical protein binding
B	0042981	biological_process	regulation of apoptotic process
B	0043296	cellular_component	apical junction complex
B	0044305	cellular_component	calyx of Held
B	0045176	biological_process	apical protein localization
B	0045202	cellular_component	synapse
B	0045582	biological_process	positive regulation of T cell differentiation
B	0045596	biological_process	negative regulation of cell differentiation
B	0045597	biological_process	positive regulation of cell differentiation
B	0045663	biological_process	positive regulation of myoblast differentiation
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0048156	molecular_function	tau protein binding
B	0048870	biological_process	cell motility
B	0050998	molecular_function	nitric-oxide synthase binding
B	0051621	biological_process	regulation of norepinephrine uptake
B	0051623	biological_process	positive regulation of norepinephrine uptake
B	0051726	biological_process	regulation of cell cycle
B	0070062	cellular_component	extracellular exosome
B	0070160	cellular_component	tight junction
B	0070316	biological_process	regulation of G0 to G1 transition
B	0070527	biological_process	platelet aggregation
B	0071564	cellular_component	npBAF complex
B	0071565	cellular_component	nBAF complex
B	0071896	biological_process	protein localization to adherens junction
B	0072562	cellular_component	blood microparticle
B	0072749	biological_process	cellular response to cytochalasin B
B	0097433	cellular_component	dense body
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098793	cellular_component	presynapse
B	0098871	cellular_component	postsynaptic actin cytoskeleton
B	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
B	0098974	biological_process	postsynaptic actin cytoskeleton organization
B	0098978	cellular_component	glutamatergic synapse
B	0140092	cellular_component	bBAF complex
B	0140288	cellular_component	GBAF complex
B	0141108	molecular_function	transporter regulator activity
B	0150111	biological_process	regulation of transepithelial transport
B	1900242	biological_process	regulation of synaptic vesicle endocytosis
B	1902459	biological_process	positive regulation of stem cell population maintenance
B	1903076	biological_process	regulation of protein localization to plasma membrane
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
B	1990904	cellular_component	ribonucleoprotein complex
B	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
B	2000779	biological_process	regulation of double-strand break repair
B	2000781	biological_process	positive regulation of double-strand break repair
B	2000819	biological_process	regulation of nucleotide-excision repair
C	0000723	biological_process	telomere maintenance
C	0000776	cellular_component	kinetochore
C	0000785	cellular_component	chromatin
C	0000786	cellular_component	nucleosome
C	0003407	biological_process	neural retina development
C	0003682	molecular_function	chromatin binding
C	0003713	molecular_function	transcription coactivator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005886	cellular_component	plasma membrane
C	0006275	biological_process	regulation of DNA replication
C	0006282	biological_process	regulation of DNA repair
C	0006338	biological_process	chromatin remodeling
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0007165	biological_process	signal transduction
C	0007399	biological_process	nervous system development
C	0008284	biological_process	positive regulation of cell population proliferation
C	0016363	cellular_component	nuclear matrix
C	0016514	cellular_component	SWI/SNF complex
C	0016586	cellular_component	RSC-type complex
C	0021510	biological_process	spinal cord development
C	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
C	0031011	cellular_component	Ino80 complex
C	0031492	molecular_function	nucleosomal DNA binding
C	0032991	cellular_component	protein-containing complex
C	0033044	biological_process	regulation of chromosome organization
C	0035060	cellular_component	brahma complex
C	0035267	cellular_component	NuA4 histone acetyltransferase complex
C	0042981	biological_process	regulation of apoptotic process
C	0045582	biological_process	positive regulation of T cell differentiation
C	0045596	biological_process	negative regulation of cell differentiation
C	0045597	biological_process	positive regulation of cell differentiation
C	0045663	biological_process	positive regulation of myoblast differentiation
C	0045739	biological_process	positive regulation of DNA repair
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045995	biological_process	regulation of embryonic development
C	0048731	biological_process	system development
C	0051726	biological_process	regulation of cell cycle
C	0060382	biological_process	regulation of DNA strand elongation
C	0070316	biological_process	regulation of G0 to G1 transition
C	0071564	cellular_component	npBAF complex
C	0140288	cellular_component	GBAF complex
C	1902459	biological_process	positive regulation of stem cell population maintenance
C	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
C	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
C	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
C	2000779	biological_process	regulation of double-strand break repair
C	2000781	biological_process	positive regulation of double-strand break repair
C	2000819	biological_process	regulation of nucleotide-excision repair
D	0000785	cellular_component	chromatin
D	0003779	molecular_function	actin binding
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0006338	biological_process	chromatin remodeling
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0008284	biological_process	positive regulation of cell population proliferation
D	0016514	cellular_component	SWI/SNF complex
D	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
D	0045596	biological_process	negative regulation of cell differentiation
D	0070316	biological_process	regulation of G0 to G1 transition
D	0140288	cellular_component	GBAF complex
D	1902459	biological_process	positive regulation of stem cell population maintenance
D	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
D	2000781	biological_process	positive regulation of double-strand break repair
D	2000819	biological_process	regulation of nucleotide-excision repair

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LILDSGATHTTA

Chain	Residue	Details
C	LEU169-ALA180

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
B	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYEE

Chain	Residue	Details
C	TRP411-GLU419
B	TRP356-GLU364

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
B	LEU104-ARG116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"23673617","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Cross-link: {"description":"(Microbial infection) Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-50); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"PubMed","id":"19015515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2010","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)