9UX9

local ATPase-NCP structure of the ncBAF-nucleosome complex in the ADP-BeFx-bound state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0030527	molecular_function	structural constituent of chromatin
A	0031492	molecular_function	nucleosomal DNA binding
A	0031507	biological_process	heterochromatin formation
B	0000786	cellular_component	nucleosome
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0031507	biological_process	heterochromatin formation
C	0000786	cellular_component	nucleosome
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0030527	molecular_function	structural constituent of chromatin
C	0031507	biological_process	heterochromatin formation
D	0000786	cellular_component	nucleosome
D	0002227	biological_process	innate immune response in mucosa
D	0003677	molecular_function	DNA binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0019731	biological_process	antibacterial humoral response
D	0030527	molecular_function	structural constituent of chromatin
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0000786	cellular_component	nucleosome
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0030527	molecular_function	structural constituent of chromatin
E	0031492	molecular_function	nucleosomal DNA binding
E	0031507	biological_process	heterochromatin formation
F	0000786	cellular_component	nucleosome
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
F	0031507	biological_process	heterochromatin formation
G	0000786	cellular_component	nucleosome
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0030527	molecular_function	structural constituent of chromatin
G	0031507	biological_process	heterochromatin formation
H	0000786	cellular_component	nucleosome
H	0002227	biological_process	innate immune response in mucosa
H	0003677	molecular_function	DNA binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0006325	biological_process	chromatin organization
H	0019731	biological_process	antibacterial humoral response
H	0030527	molecular_function	structural constituent of chromatin
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0000776	cellular_component	kinetochore
K	0000785	cellular_component	chromatin
K	0000791	cellular_component	euchromatin
K	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
K	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
K	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
K	0001188	biological_process	RNA polymerase I preinitiation complex assembly
K	0001221	molecular_function	transcription coregulator binding
K	0001650	cellular_component	fibrillar center
K	0002039	molecular_function	p53 binding
K	0003407	biological_process	neural retina development
K	0003677	molecular_function	DNA binding
K	0003682	molecular_function	chromatin binding
K	0003713	molecular_function	transcription coactivator activity
K	0003714	molecular_function	transcription corepressor activity
K	0004386	molecular_function	helicase activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005726	cellular_component	perichromatin fibrils
K	0005730	cellular_component	nucleolus
K	0006338	biological_process	chromatin remodeling
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0007399	biological_process	nervous system development
K	0008094	molecular_function	ATP-dependent activity, acting on DNA
K	0008284	biological_process	positive regulation of cell population proliferation
K	0016020	cellular_component	membrane
K	0016363	cellular_component	nuclear matrix
K	0016514	cellular_component	SWI/SNF complex
K	0016887	molecular_function	ATP hydrolysis activity
K	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
K	0030177	biological_process	positive regulation of Wnt signaling pathway
K	0030308	biological_process	negative regulation of cell growth
K	0030957	molecular_function	Tat protein binding
K	0031492	molecular_function	nucleosomal DNA binding
K	0031507	biological_process	heterochromatin formation
K	0032991	cellular_component	protein-containing complex
K	0042802	molecular_function	identical protein binding
K	0043923	biological_process	host-mediated activation of viral transcription
K	0045582	biological_process	positive regulation of T cell differentiation
K	0045596	biological_process	negative regulation of cell differentiation
K	0045597	biological_process	positive regulation of cell differentiation
K	0045663	biological_process	positive regulation of myoblast differentiation
K	0045815	biological_process	transcription initiation-coupled chromatin remodeling
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0050681	molecular_function	nuclear androgen receptor binding
K	0060766	biological_process	negative regulation of androgen receptor signaling pathway
K	0070182	molecular_function	DNA polymerase binding
K	0070316	biological_process	regulation of G0 to G1 transition
K	0071564	cellular_component	npBAF complex
K	0071565	cellular_component	nBAF complex
K	0106222	molecular_function	lncRNA binding
K	0120162	biological_process	positive regulation of cold-induced thermogenesis
K	0140658	molecular_function	ATP-dependent chromatin remodeler activity
K	0140750	molecular_function	nucleosome array spacer activity
K	1901798	biological_process	positive regulation of signal transduction by p53 class mediator
K	1901838	biological_process	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
K	1902459	biological_process	positive regulation of stem cell population maintenance
K	1902661	biological_process	positive regulation of glucose mediated signaling pathway
K	1902895	biological_process	positive regulation of miRNA transcription
K	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
K	2000781	biological_process	positive regulation of double-strand break repair
K	2000819	biological_process	regulation of nucleotide-excision repair

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

---

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SevFiqlpSrkelp..EYYelIrkpVdfkkIkerirnhk..Yrslndlekdvml.LcqNAqtF

Chain	Residue	Details
K	SER1498-PHE1555

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-methacryllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	165
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	162
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	79
Details	Region: {"description":"Sufficient for interaction with DLX1","evidences":[{"source":"UniProtKB","id":"Q3TKT4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	Motif: {"description":"DEGH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---